PMID- 37794740
OWN - NLM
STAT- MEDLINE
DCOM- 20240103
LR  - 20240106
IS  - 2040-1124 (Electronic)
IS  - 2040-1116 (Print)
IS  - 2040-1116 (Linking)
VI  - 15
IP  - 1
DP  - 2024 Jan
TI  - Sympathetic skin response for early detection of type 2 diabetic peripheral 
      neuropathy and nephropathy.
PG  - 106-112
LID - 10.1111/jdi.14091 [doi]
AB  - BACKGROUND: Diabetic peripheral neuropathy (DPN) and diabetic nephropathy (DN) 
      are common complications of type 2 diabetes mellitus (T2DM). Although nerve 
      conduction studies (NCS) and sympathetic skin response (SSR) can detect DPN, the 
      more sensitive method for early diagnosis remains unclear. Furthermore, whether 
      DPN can be used as a predictor for diabetic nephropathy needs clarification. 
      METHODS: We evaluated nerve conduction studies, sympathetic skin response, and 
      the diabetic nephropathy indicator microalbuminuria (MAU) in 192 patients with 
      type 2 diabetes mellitus and 50 healthy controls. RESULTS: Patients with type 2 
      diabetes mellitus showed a lower sensory nerve conduction velocity (SCV), sensory 
      active nerve potential (SNAP), motor nerve conduction velocity (MCV), and 
      compound motor action potential (CMAP) than the controls on NCS. Abnormal rates 
      for nerve conduction studies and sympathetic skin response were 75.0% and 83.3%, 
      respectively, in patients with type 2 diabetes mellitus. Interestingly, 54.2% of 
      patients with normal nerve conduction studies had an abnormal sympathetic skin 
      response. Moreover, we found a positive correlation between sympathetic skin 
      response and microalbuminuria for the first time. The abnormal rate of 
      microalbuminuria was 53.8%, lower than that of abnormal nerve conduction studies 
      or sympathetic skin response patients. CONCLUSION: Sympathetic skin response is a 
      more sensitive method than nerve conduction studies for the early diagnosis of 
      diabetic peripheral neuropathy. Abnormal sympathetic skin response might serve as 
      an indicator for early diabetic nephropathy. Additionally, diabetic peripheral 
      neuropathy may occur earlier than diabetic nephropathy in the development of type 
      2 diabetes mellitus.
CI  - (c) 2023 The Authors. Journal of Diabetes Investigation published by Asian 
      Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, 
      Ltd.
FAU - Liu, Hongying
AU  - Liu H
AD  - Department of Neurology, Zhujiang Hospital, Southern Medical University, 
      Guangzhou, China.
AD  - Department of Neurology, The Second Affiliated Hospital of Guangzhou Medical 
      University, Guangzhou, China.
FAU - Tan, Sheng
AU  - Tan S
AUID- ORCID: 0000-0001-8330-1092
AD  - Department of Neurology, Zhujiang Hospital, Southern Medical University, 
      Guangzhou, China.
FAU - Ma, Zhenyu
AU  - Ma Z
AD  - Department of Neurology, The Second Affiliated Hospital of Guangzhou Medical 
      University, Guangzhou, China.
FAU - Gao, Qingchun
AU  - Gao Q
AD  - Department of Neurology, The Second Affiliated Hospital of Guangzhou Medical 
      University, Guangzhou, China.
FAU - Yang, Weihong
AU  - Yang W
AD  - Department of Neurology, Zhujiang Hospital, Southern Medical University, 
      Guangzhou, China.
LA  - eng
GR  - 201704020043/Guangzhou Science, Technology and Innovation Commission/
GR  - 81701240/National Natural Science Foundation of China/
GR  - 2016A030310283/Natural Science Foundation of Guangdong Province/
PT  - Journal Article
DEP - 20231004
PL  - Japan
TA  - J Diabetes Investig
JT  - Journal of diabetes investigation
JID - 101520702
SB  - IM
MH  - Humans
MH  - *Diabetic Neuropathies/etiology/complications
MH  - *Diabetes Mellitus, Type 2/complications
MH  - *Diabetic Nephropathies/etiology/complications
MH  - Early Diagnosis
MH  - Neural Conduction/physiology
PMC - PMC10759718
OTO - NOTNLM
OT  - Diabetic nephropathy
OT  - Diabetic peripheral neuropathy
OT  - Microalbuminuria
OT  - Nerve conduction studies
OT  - Sympathetic skin response
EDAT- 2023/10/05 06:44
MHDA- 2024/01/03 09:43
PMCR- 2023/10/04
CRDT- 2023/10/05 02:42
PHST- 2023/08/16 00:00 [revised]
PHST- 2023/03/27 00:00 [received]
PHST- 2023/08/29 00:00 [accepted]
PHST- 2024/01/03 09:43 [medline]
PHST- 2023/10/05 06:44 [pubmed]
PHST- 2023/10/05 02:42 [entrez]
PHST- 2023/10/04 00:00 [pmc-release]
AID - JDI14091 [pii]
AID - 10.1111/jdi.14091 [doi]
PST - ppublish
SO  - J Diabetes Investig. 2024 Jan;15(1):106-112. doi: 10.1111/jdi.14091. Epub 2023 
      Oct 4.