PMID- 37794765
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231020
IS  - 2040-3372 (Electronic)
IS  - 2040-3364 (Linking)
VI  - 15
IP  - 40
DP  - 2023 Oct 20
TI  - Large area CVD-grown vertically and horizontally oriented MoS(2) nanostructures 
      as SERS biosensors for single molecule detection.
PG  - 16480-16492
LID - 10.1039/d3nr02284f [doi]
AB  - Surface-enhanced Raman scattering (SERS) has attracted extensive attention for 
      its rapid, ultra-sensitive, non-destructive and label-free fingerprint detection 
      of trace molecules. Recently, two-dimensional transition metal dichalcogenides 
      have been investigated as SERS substrates owing to their low cost, simple 
      synthesis, excellent optical behavior, tunable bandgap, high carrier mobility and 
      good biocompatibility. Here, we have synthesized 2H-MoS(2) nanostructures of 
      different morphologies (vertically and horizontally oriented) via the chemical 
      vapor deposition (CVD) method on different substrates (FTO-coated glass, Si and 
      SiO(2)-Si) and utilized them as SERS substrates for the detection of bilirubin 
      and vitamin B(12) biomolecules. The strong vibronic coupling within the charge 
      transfer (CT) process leads to photo-induced charge transfer (PICT) resonance, 
      showing enhanced SERS activity. This CT mechanism is further confirmed by 
      observing quenching of the room temperature PL spectra and enhanced SERS signals 
      of biomolecules over SERS substrates. To the best of our knowledge, the detection 
      limit in this work (10(-11) M for bilirubin and 10(-8) M for vitamin B(12)) is 
      considerably higher than previously reported values. The improved efficiency of 
      the PICT process can be achieved at low temperature, and this is confirmed when 
      performing low temperature-dependent photoluminescence (PL) studies on SERS 
      substrates. Furthermore, we also demonstrated enhanced SERS activity at low 
      temperature on CVD-grown pristine MoS(2) films over different substrates for 
      biomolecule detection for the first time, attributing this activity to the 
      enhanced PICT process at low temperature.
FAU - Singh, Ankita
AU  - Singh A
AD  - School of Materials Science and Technology, Indian Institute of Technology 
      (Banaras Hindu University), Varanasi-221005, India. akmishra.mst@iitbhu.ac.in.
FAU - Mishra, Ashish Kumar
AU  - Mishra AK
AUID- ORCID: 0000-0003-0192-7417
AD  - School of Materials Science and Technology, Indian Institute of Technology 
      (Banaras Hindu University), Varanasi-221005, India. akmishra.mst@iitbhu.ac.in.
LA  - eng
PT  - Journal Article
DEP - 20231020
PL  - England
TA  - Nanoscale
JT  - Nanoscale
JID - 101525249
SB  - IM
EDAT- 2023/10/05 06:43
MHDA- 2023/10/05 06:44
CRDT- 2023/10/05 03:09
PHST- 2023/10/05 06:44 [medline]
PHST- 2023/10/05 06:43 [pubmed]
PHST- 2023/10/05 03:09 [entrez]
AID - 10.1039/d3nr02284f [doi]
PST - epublish
SO  - Nanoscale. 2023 Oct 20;15(40):16480-16492. doi: 10.1039/d3nr02284f.