PMID- 37795636
OWN - NLM
STAT- MEDLINE
DCOM- 20231122
LR  - 20240201
IS  - 1097-4652 (Electronic)
IS  - 0021-9541 (Linking)
VI  - 238
IP  - 11
DP  - 2023 Nov
TI  - BMP6 participates in the pathogenesis of adolescent idiopathic scoliosis by 
      regulating osteopenia.
PG  - 2586-2599
LID - 10.1002/jcp.31111 [doi]
AB  - Adolescent idiopathic scoliosis (AIS) is a complex disease characterized by 
      three-dimensional structural deformities of the spine. Its pathogenesis is 
      associated with osteopenia. Bone-marrow-derived mesenchymal stem cells (BMSCs) 
      play an important role in bone metabolism. We detected 1919 differentially 
      expressed mRNAs and 744 differentially expressed lncRNAs in BMSCs from seven 
      patients with AIS and five patients without AIS via high-throughput sequencing. 
      Multiple analyses identified bone morphogenetic protein-6 (BMP6) as a hub gene 
      that regulates the abnormal osteogenic differentiation of BMSCs in AIS. BMP6 
      expression was found to be decreased in AIS and its knockdown in human BMSCs 
      significantly altered the degree of osteogenic differentiation. Additionally, 
      CAP1-217 has been shown to be a potential upstream regulatory molecule of BMP6. 
      We showed that CAP1-217 knockdown downregulated the expression of BMP6 and the 
      osteogenic differentiation of BMSCs. Simultaneously, knockout of BMP6 in 
      zebrafish embryos significantly increased the deformity rate. The findings of 
      this study suggest that BMP6 is a key gene that regulates the abnormal osteogenic 
      differentiation of BMSCs in AIS via the CAP1-217/BMP6/RUNX2 axis.
CI  - (c) 2023 Wiley Periodicals LLC.
FAU - Tang, Hao
AU  - Tang H
AD  - Department of Spine Surgery and Orthopaedics, Xiangya Hospital, Central South 
      University, Changsha, Hunan, People's Republic of China.
AD  - National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, 
      Central South University, Changsha, Hunan, People's Republic of China.
FAU - Li, Jiong
AU  - Li J
AD  - Department of Spine Surgery and Orthopaedics, Xiangya Hospital, Central South 
      University, Changsha, Hunan, People's Republic of China.
AD  - National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, 
      Central South University, Changsha, Hunan, People's Republic of China.
FAU - Li, Jia-Ke
AU  - Li JK
AD  - Department of General Surgery, The Third Xiangya Hospital of Central South 
      University, Changsha, People's Republic of China.
FAU - He, Si-Han
AU  - He SH
AD  - Department of Spine Surgery and Orthopaedics, Xiangya Hospital, Central South 
      University, Changsha, Hunan, People's Republic of China.
AD  - National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, 
      Central South University, Changsha, Hunan, People's Republic of China.
FAU - Xiang, Gang
AU  - Xiang G
AD  - Department of Spine Surgery and Orthopaedics, Xiangya Hospital, Central South 
      University, Changsha, Hunan, People's Republic of China.
AD  - National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, 
      Central South University, Changsha, Hunan, People's Republic of China.
FAU - Rong, Rong
AU  - Rong R
AD  - National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, 
      Central South University, Changsha, Hunan, People's Republic of China.
AD  - Hunan Key Laboratory of Ophthalmology, Xiangya Hospital, Central South 
      University, Changsha, Hunan, People's Republic of China.
FAU - Liang, Zhuo-Tao
AU  - Liang ZT
AD  - Department of Spine Surgery and Orthopaedics, Xiangya Hospital, Central South 
      University, Changsha, Hunan, People's Republic of China.
AD  - National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, 
      Central South University, Changsha, Hunan, People's Republic of China.
FAU - Zhang, Hong-Qi
AU  - Zhang HQ
AUID- ORCID: 0000-0001-5750-4910
AD  - Department of Spine Surgery and Orthopaedics, Xiangya Hospital, Central South 
      University, Changsha, Hunan, People's Republic of China.
AD  - National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, 
      Central South University, Changsha, Hunan, People's Republic of China.
LA  - eng
GR  - 81772298/Natural Science Foundation of China/
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20231005
PL  - United States
TA  - J Cell Physiol
JT  - Journal of cellular physiology
JID - 0050222
RN  - 0 (BMP6 protein, human)
RN  - 0 (Bone Morphogenetic Protein 6)
SB  - IM
MH  - Humans
MH  - Adolescent
MH  - Animals
MH  - *Scoliosis/genetics/pathology
MH  - Osteogenesis/genetics
MH  - Zebrafish/genetics
MH  - Spine/metabolism
MH  - Cell Differentiation/genetics
MH  - *Bone Diseases, Metabolic/genetics/metabolism
MH  - Cells, Cultured
MH  - Bone Marrow Cells/metabolism
MH  - Bone Morphogenetic Protein 6/genetics
OTO - NOTNLM
OT  - BMP6
OT  - CAP1-217
OT  - adipogenic differentiation
OT  - adolescent idiopathic scoliosis (AIS)
OT  - bone marrow-derived mesenchymal stem cells (BMSCs)
OT  - osteogenic differentiation
EDAT- 2023/10/05 06:43
MHDA- 2023/11/22 06:42
CRDT- 2023/10/05 05:34
PHST- 2023/08/08 00:00 [revised]
PHST- 2023/05/22 00:00 [received]
PHST- 2023/08/17 00:00 [accepted]
PHST- 2023/11/22 06:42 [medline]
PHST- 2023/10/05 06:43 [pubmed]
PHST- 2023/10/05 05:34 [entrez]
AID - 10.1002/jcp.31111 [doi]
PST - ppublish
SO  - J Cell Physiol. 2023 Nov;238(11):2586-2599. doi: 10.1002/jcp.31111. Epub 2023 Oct 
      5.