PMID- 37795764
OWN - NLM
STAT- MEDLINE
DCOM- 20240123
LR  - 20240412
IS  - 1552-4981 (Electronic)
IS  - 1552-4973 (Linking)
VI  - 112
IP  - 1
DP  - 2024 Jan
TI  - Influence of structural parameters of 3D-printed triply periodic minimal surface 
      gyroid porous scaffolds on compression performance, cell response, and bone 
      regeneration.
PG  - e35337
LID - 10.1002/jbm.b.35337 [doi]
AB  - In this study, multi-scale triply periodic minimal surface (TPMS) porous 
      scaffolds with uniform and radial gradient distribution on pore size were printed 
      based on the selective laser melting technology, and the influences of porosity, 
      pore size and radial pore size distribution on compression mechanical properties, 
      cell behavior, and bone regeneration behavior were analyzed. The results showed 
      that the compression performance of the uniform porous scaffolds with high 
      porosity was similar to that of cancellous bone of pig tibia, and the gradient 
      porous scaffolds have higher elastic modulus and compressive toughness. After 
      4 days of cell culture, cells were distributed on the surface of scaffolds 
      mostly, and the number of adherent cells was higher on the small pore size porous 
      scaffolds; After 7 days, the area and density of cell proliferation on the 
      scaffolds were improved; After 14 days, the cells on the small pore size 
      scaffolds tended to migrate to adjacent pores. Animal implantation experiments 
      showed that collagen fiber osteoid was intermittent on scaffolds with high 
      porosity and large pore size, which was not conducive to bone formation. The 
      appropriate pore size and porosity of bone regeneration were 792 um and 83%, 
      respectively, and the regenerative ability of gradient pore size was better than 
      that of uniform pore size. Our study explains the rules of TPMS gyroid structure 
      parameters on compression performance, cell response and bone regeneration, and 
      provides a reference value for the design of bone repair scaffolds for clinical 
      orthopedics.
CI  - (c) 2023 Wiley Periodicals LLC.
FAU - Wang, Zhenglun
AU  - Wang Z
AUID- ORCID: 0000-0002-3984-9779
AD  - Tribology Research Institute, Key Laboratory for Advanced Technology of Materials 
      of Ministry of Education, Southwest Jiaotong University, Chengdu, China.
FAU - Liao, Bo
AU  - Liao B
AD  - Tribology Research Institute, Key Laboratory for Advanced Technology of Materials 
      of Ministry of Education, Southwest Jiaotong University, Chengdu, China.
FAU - Liu, Yongsheng
AU  - Liu Y
AD  - State Key Laboratory of Vanadium and Titanium Resources Comprehensive 
      Utilization, Pangang Group Research Institute Co., Ltd., Panzhihua, China.
AD  - R & D Center for High-end Parts, Chengdu Advanced Metal Materials Industry 
      Technology Research Institute Co., Ltd., Chengdu, China.
FAU - Liao, Yunqian
AU  - Liao Y
AD  - Tribology Research Institute, Key Laboratory for Advanced Technology of Materials 
      of Ministry of Education, Southwest Jiaotong University, Chengdu, China.
FAU - Zhou, Yu
AU  - Zhou Y
AD  - Tribology Research Institute, Key Laboratory for Advanced Technology of Materials 
      of Ministry of Education, Southwest Jiaotong University, Chengdu, China.
FAU - Li, Wei
AU  - Li W
AD  - Tribology Research Institute, Key Laboratory for Advanced Technology of Materials 
      of Ministry of Education, Southwest Jiaotong University, Chengdu, China.
LA  - eng
GR  - 2018JY0552/Key R&D Project of Sichuan Province/
GR  - Vanadium Titanium Alliance Fund of Panzhihua Iron and Steel Co. Ltd/
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20231005
PL  - United States
TA  - J Biomed Mater Res B Appl Biomater
JT  - Journal of biomedical materials research. Part B, Applied biomaterials
JID - 101234238
SB  - IM
MH  - Animals
MH  - Swine
MH  - Porosity
MH  - *Tissue Scaffolds/chemistry
MH  - *Cancellous Bone
MH  - Bone Regeneration
MH  - Printing, Three-Dimensional
MH  - Tissue Engineering/methods
OTO - NOTNLM
OT  - 3D printing
OT  - TPMS gyroid porous scaffolds
OT  - bone regeneration
OT  - cell response
OT  - compression performance
EDAT- 2023/10/05 12:42
MHDA- 2024/01/23 06:43
CRDT- 2023/10/05 06:37
PHST- 2023/08/19 00:00 [revised]
PHST- 2023/04/18 00:00 [received]
PHST- 2023/09/18 00:00 [accepted]
PHST- 2024/01/23 06:43 [medline]
PHST- 2023/10/05 12:42 [pubmed]
PHST- 2023/10/05 06:37 [entrez]
AID - 10.1002/jbm.b.35337 [doi]
PST - ppublish
SO  - J Biomed Mater Res B Appl Biomater. 2024 Jan;112(1):e35337. doi: 
      10.1002/jbm.b.35337. Epub 2023 Oct 5.