PMID- 37796541
OWN - NLM
STAT- MEDLINE
DCOM- 20231128
LR  - 20231128
IS  - 2769-755X (Electronic)
IS  - 2769-7541 (Linking)
VI  - 132
IP  - 8
DP  - 2023 Nov
TI  - Clinical high risk for psychosis syndrome is associated with reduced neural 
      responding to unpleasant images.
PG  - 1060-1071
LID - 10.1037/abn0000862 [doi]
AB  - Deficits in emotion processing are core features of psychotic disorders. 
      Electrophysiology research in schizophrenia suggests deficits in sustained 
      engagement with emotional content (indexed by the late positive potential [LPP]) 
      may contribute to emotion processing impairments. Despite similar behavioral 
      emotion processing dysfunction in those at clinical high risk (CHR) for 
      psychosis, limited research has examined neural mechanisms of impaired emotion 
      processing in the high-risk period, where research can inform risk models. To 
      examine mechanisms of emotion processing deficits in those at CHR for psychosis, 
      the present study used a passive viewing task to elicit the LPP in response to 
      emotionally engaging and neutral stimuli in 28 CHR and 32 control participants 
      (60% female). Relative to controls, CHR participants showed reduced LPP amplitude 
      when viewing unpleasant images (d = 0.75, p = .005) but similar LPP amplitude in 
      response to both neutral (d = 0.35, p = .19) and pleasant images (d = 0.31, p = 
      .24). This pattern suggests that individuals at CHR for psychosis exhibit a 
      deficit in sustained engagement with unpleasant stimuli. Clinical and trait 
      questionnaires were administered to examine potential exploratory explanations 
      for group differences in LPP amplitude. Consistent with evidence suggesting LPP 
      amplitude reflects engagement of approach/avoidance motivational systems, greater 
      LPP amplitude was associated with greater trait-level behavioral avoidance in 
      control participants (r = .42, p = .032) but not CHR participants (r = -.21, p = 
      .40). Together, the present research is consistent with LPP studies in psychosis 
      and implicates reduced sustained engagement with emotional content in the 
      high-risk period. (PsycInfo Database Record (c) 2023 APA, all rights reserved).
FAU - Osborne, K Juston
AU  - Osborne KJ
AD  - Department of Psychology, Northwestern University.
FAU - Zhang, Wendy
AU  - Zhang W
AD  - Department of Psychology, San Diego State University.
FAU - Gupta, Tina
AU  - Gupta T
AD  - Department of Psychology, Northwestern University.
FAU - Farrens, Jaclyn
AU  - Farrens J
AD  - Department of Psychology, San Diego State University.
FAU - Geiger, McKena
AU  - Geiger M
AD  - Department of Psychology, San Diego State University.
FAU - Kraus, Brian
AU  - Kraus B
AD  - Department of Psychology, Northwestern University.
FAU - Krugel, Chloe
AU  - Krugel C
AD  - Department of Psychology, Northwestern University.
FAU - Nusslock, Robin
AU  - Nusslock R
AD  - Department of Psychology, Northwestern University.
FAU - Kappenman, Emily S
AU  - Kappenman ES
AD  - Department of Psychology, San Diego State University.
FAU - Mittal, Vijay A
AU  - Mittal VA
AD  - Department of Psychology, Northwestern University.
LA  - eng
GR  - NH/NIH HHS/United States
GR  - NH/NIH HHS/United States
PT  - Journal Article
DEP - 20231005
PL  - United States
TA  - J Psychopathol Clin Sci
JT  - Journal of psychopathology and clinical science
JID - 9918351179206676
SB  - IM
MH  - Humans
MH  - Female
MH  - Male
MH  - Evoked Potentials/physiology
MH  - Electroencephalography/methods
MH  - Emotions/physiology
MH  - *Psychotic Disorders
MH  - *Schizophrenia
EDAT- 2023/10/05 12:42
MHDA- 2023/11/28 06:42
CRDT- 2023/10/05 11:53
PHST- 2023/11/28 06:42 [medline]
PHST- 2023/10/05 12:42 [pubmed]
PHST- 2023/10/05 11:53 [entrez]
AID - 2024-14059-001 [pii]
AID - 10.1037/abn0000862 [doi]
PST - ppublish
SO  - J Psychopathol Clin Sci. 2023 Nov;132(8):1060-1071. doi: 10.1037/abn0000862. Epub 
      2023 Oct 5.