PMID- 37797910
OWN - NLM
STAT- MEDLINE
DCOM- 20231225
LR  - 20231225
IS  - 1873-1597 (Electronic)
IS  - 1572-1000 (Linking)
VI  - 44
DP  - 2023 Dec
TI  - Characteristics of the retina and choroid in fibromyalgia patients and their 
      correlation with disease severity and quality of life.
PG  - 103819
LID - S1572-1000(23)00546-X [pii]
LID - 10.1016/j.pdpdt.2023.103819 [doi]
AB  - BACKGROUND: To evaluate retinal and choroidal characteristics of fibromyalgia 
      (FM) patients using spectral-domain optical coherence tomography (SD-OCT), to 
      compare them with healthy controls, and to determine the correlation of these 
      measurements with disease severity and quality of life. METHODS: Thirty-nine eyes 
      of 39 patients with FM and 44 eyes of 44 age- and sex-matched healthy subjects 
      were enrolled. The retinal nerve fiber layer (RNFL), central macular thickness 
      (CMT), and choroidal thickness (CT) measurements of the subjects were obtained 
      using SD-OCT (Maestro, Topcon Co. Tokyo, Japan), choroidal vascular index (CVI) 
      was calculated by using the binarization method and the results were compared. 
      Disease duration (DD), widespread pain index (WPI), symptom severity scale (SSS), 
      visual analog scale (VAS), ocular pain assessment survey (OPAS), FM impact 
      questionnaire (FIQ), European Quality of Life-5 Dimensions-3 level (EQ-5D-3 L), 
      European Quality VAS score (EQ-VAS) and use of pregabalin were recorded. 
      Correlations between the SD-OCT results and the FM parameters were evaluated. 
      RESULTS: No significant difference was found in terms of age and gender 
      (p = 0.612, p = 0.244 respectively). Patients in the FM group had significantly 
      thinner RNFL superior quadrant and CT (p = 0,009 and p < 0.001, respectively). 
      CVI was significantly higher in the FM group (p < 0.001). There was an inverse 
      correlation between OPAS and CT (r = -0.379, p = 0.027) and between VAS and CVI 
      (r = -0.398, p = 0.020). The use of pregabalin had no effect on SD-OCT 
      (p > 0.05). CONCLUSION: Patients with FM demonstrated reduced RNFL superior 
      quadrant and CT and increased CVI. Ocular and general body pain in FM was found 
      to be associated with SD-OCT.
CI  - Copyright (c) 2023 The Author(s). Published by Elsevier B.V. All rights reserved.
FAU - Sevimli, Neslihan
AU  - Sevimli N
AD  - Department of Ophthalmology, Fatih Sultan Mehmet Training and Research Hospital, 
      Atasehir, Istanbul, Turkey. Electronic address: neslihandumanli@gmail.com.
FAU - Kurna, Sevda Aydin
AU  - Kurna SA
AD  - Department of Ophthalmology, Fatih Sultan Mehmet Training and Research Hospital, 
      Atasehir, Istanbul, Turkey.
FAU - Silte Karamanlioglu, Ayse Duygu
AU  - Silte Karamanlioglu AD
AD  - Department of Physical Medicine and Rehabilitation, Fatih Sultan Mehmet Training 
      and Research Hospital, Atasehir, Istanbul, Turkey.
FAU - Unlu Ozkan, Feyza
AU  - Unlu Ozkan F
AD  - Department of Physical Medicine and Rehabilitation, Fatih Sultan Mehmet Training 
      and Research Hospital, Atasehir, Istanbul, Turkey.
FAU - Aktas, Ilknur
AU  - Aktas I
AD  - Department of Physical Medicine and Rehabilitation, Fatih Sultan Mehmet Training 
      and Research Hospital, Atasehir, Istanbul, Turkey.
FAU - Cakir, Muhammet
AU  - Cakir M
AD  - Department of Ophthalmology, Fatih Sultan Mehmet Training and Research Hospital, 
      Atasehir, Istanbul, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20231004
PL  - Netherlands
TA  - Photodiagnosis Photodyn Ther
JT  - Photodiagnosis and photodynamic therapy
JID - 101226123
RN  - 55JG375S6M (Pregabalin)
RN  - 0 (Photosensitizing Agents)
SB  - IM
MH  - Humans
MH  - *Fibromyalgia
MH  - Pregabalin/therapeutic use
MH  - Quality of Life
MH  - *Photochemotherapy/methods
MH  - Photosensitizing Agents
MH  - Retina/diagnostic imaging
MH  - Choroid
MH  - Tomography, Optical Coherence/methods
MH  - Patient Acuity
MH  - Pain
OTO - NOTNLM
OT  - Choroidal thickness
OT  - Choroidal vascular index
OT  - Fibromyalgia
OT  - Spectral-domain optical coherence tomography
COIS- Declaration of Competing Interest No conflicts of interest between the authors 
      and/or family members of the scientific and medical committee members or members 
      of the potential conflicts of interest, counseling, expertise, working 
      conditions, shareholding, and similar situations in any firm.
EDAT- 2023/10/06 00:43
MHDA- 2023/12/25 06:42
CRDT- 2023/10/05 19:34
PHST- 2023/08/03 00:00 [received]
PHST- 2023/09/09 00:00 [revised]
PHST- 2023/09/26 00:00 [accepted]
PHST- 2023/12/25 06:42 [medline]
PHST- 2023/10/06 00:43 [pubmed]
PHST- 2023/10/05 19:34 [entrez]
AID - S1572-1000(23)00546-X [pii]
AID - 10.1016/j.pdpdt.2023.103819 [doi]
PST - ppublish
SO  - Photodiagnosis Photodyn Ther. 2023 Dec;44:103819. doi: 
      10.1016/j.pdpdt.2023.103819. Epub 2023 Oct 4.