PMID- 37800320
OWN - NLM
STAT- MEDLINE
DCOM- 20231216
LR  - 20240105
IS  - 2472-1727 (Electronic)
VI  - 115
IP  - 20
DP  - 2023 Dec 1
TI  - Maternal-fetal safety evaluation of an aqueous extract of Casearia sylvestris 
      leaves in rats.
PG  - 1899-1911
LID - 10.1002/bdr2.2257 [doi]
AB  - BACKGROUND: This study evaluated the maternal, embryotoxic, and teratogenic 
      effects of the aqueous extract of Casearia sylvestris (AECS), a species listed in 
      the Unique Health System of Brazil, and widely used for treating several 
      conditions, such as diarrhea, wounds, pain, and ulcers. METHODS: Pregnant rats 
      were daily treated orally with 0, 175, 350, or 700 mg/kg/body weight of AECS, 
      from gestational day (GD) 6 to 15 (organogenesis period). On GD 20, the pregnant 
      rats were euthanized, and the litters submitted to an assessment of fetal 
      development. RESULTS: No clinical signs of toxicity were observed in the dams 
      during the treatment. In the embryo-fetal development study, a significant 
      increase in the basal zone height of the placenta was observed in the 
      intermediate dose group. Furthermore, there was a significant increase in the 
      relative anogenital distance measurement of female fetuses in the lowest and 
      intermediate dose groups. Although no visceral abnormalities were observed in the 
      treated-fetuses, skeletal anomalies evidenced by changes in the ossification of 
      the sternum and the presence of supernumerary ribs were found in the intermediate 
      and high dose groups. CONCLUSION: In conclusion, the treatment with AECS during 
      organogenesis at this dose level had detrimental effects on the normal 
      development of fetuses.
CI  - (c) 2023 Wiley Periodicals LLC.
FAU - Nagaoka, Livia Trippe
AU  - Nagaoka LT
AD  - Department of Structural and Functional Biology, Institute of Biosciences of 
      Botucatu, Universidade Estadual Paulista - UNESP, Botucatu, Sao Paulo, Brazil.
FAU - Jorge, Barbara Campos
AU  - Jorge BC
AD  - Department of Structural and Functional Biology, Institute of Biosciences of 
      Botucatu, Universidade Estadual Paulista - UNESP, Botucatu, Sao Paulo, Brazil.
FAU - Stein, Julia
AU  - Stein J
AD  - Department of Structural and Functional Biology, Institute of Biosciences of 
      Botucatu, Universidade Estadual Paulista - UNESP, Botucatu, Sao Paulo, Brazil.
FAU - Manoel, Beatriz de Matos
AU  - Manoel BM
AD  - Department of Structural and Functional Biology, Institute of Biosciences of 
      Botucatu, Universidade Estadual Paulista - UNESP, Botucatu, Sao Paulo, Brazil.
FAU - Valente, Leticia Cardoso
AU  - Valente LC
AD  - College of Health Science, Federal University of Grande Dourados, Dourados, Mato 
      Grosso do Sul, Brazil.
FAU - de Toledo, Laura Leonel
AU  - de Toledo LL
AD  - Department of Structural and Functional Biology, Institute of Biosciences of 
      Botucatu, Universidade Estadual Paulista - UNESP, Botucatu, Sao Paulo, Brazil.
FAU - de Castro, Thiago Luis Aguayo
AU  - de Castro TLA
AD  - Center of Studies in Natural Resources, State University of Mato Grosso do Sul 
      (UEMS), Dourados, Mato Grosso do Sul, Brazil.
FAU - Kassuya, Candida Aparecida Leite
AU  - Kassuya CAL
AD  - College of Health Science, Federal University of Grande Dourados, Dourados, Mato 
      Grosso do Sul, Brazil.
FAU - Cardoso, Claudia Andrea Lima
AU  - Cardoso CAL
AD  - Center of Studies in Natural Resources, State University of Mato Grosso do Sul 
      (UEMS), Dourados, Mato Grosso do Sul, Brazil.
FAU - Arena, Arielle Cristina
AU  - Arena AC
AUID- ORCID: 0000-0002-2373-9399
AD  - Department of Structural and Functional Biology, Institute of Biosciences of 
      Botucatu, Universidade Estadual Paulista - UNESP, Botucatu, Sao Paulo, Brazil.
AD  - Toxicological Information and Assistance Center (CIATOX), Institute of 
      Biosciences of Botucatu, Univ. Estadual Paulista - Botucatu (UNESP), Botucatu, 
      Sao Paulo, Brazil.
LA  - eng
GR  - Fundacao de Amparo a Pesquisa do Estado de Sao Paulo/
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20231006
PL  - United States
TA  - Birth Defects Res
JT  - Birth defects research
JID - 101701004
SB  - IM
MH  - Pregnancy
MH  - Humans
MH  - Rats
MH  - Animals
MH  - Female
MH  - Rats, Sprague-Dawley
MH  - *Casearia
MH  - Fetal Development
MH  - Fetus
MH  - Maternal Exposure/adverse effects
OTO - NOTNLM
OT  - medicinal plants
OT  - pregnancy
OT  - rats
OT  - safety
OT  - skeletal abnormalities
OT  - teratogenicity
EDAT- 2023/10/06 06:43
MHDA- 2023/12/17 09:45
CRDT- 2023/10/06 04:43
PHST- 2023/09/20 00:00 [revised]
PHST- 2023/04/13 00:00 [received]
PHST- 2023/09/22 00:00 [accepted]
PHST- 2023/12/17 09:45 [medline]
PHST- 2023/10/06 06:43 [pubmed]
PHST- 2023/10/06 04:43 [entrez]
AID - 10.1002/bdr2.2257 [doi]
PST - ppublish
SO  - Birth Defects Res. 2023 Dec 1;115(20):1899-1911. doi: 10.1002/bdr2.2257. Epub 
      2023 Oct 6.