PMID- 37801591
OWN - NLM
STAT- MEDLINE
DCOM- 20231207
LR  - 20231217
IS  - 1728-7731 (Electronic)
IS  - 1726-4901 (Linking)
VI  - 86
IP  - 12
DP  - 2023 Dec 1
TI  - HLA-DR genotypes in patients with systemic lupus erythematosus in Taiwan.
PG  - 1060-1065
LID - 10.1097/JCMA.0000000000001009 [doi]
AB  - BACKGROUND: Different human leukocyte antigen (HLA)-DR genotypes have been known 
      to be associated with the risk of development of systemic lupus erythematosus 
      (SLE) in different populations, although Lu et al. have reported previously that 
      no correlation exists between the HLA-DR genotype and disease manifestation in 
      SLE patients in Taiwan. We investigated the effects different HLA-DR genotypes 
      had on SLE incidence in Taiwanese patients as to whether risk alleles were 
      associated with different clinical manifestations, and the effects risk alleles 
      had on the age of disease onset. METHODS: Two hundred thirty-four SLE patients 
      and 346 healthy controls were enrolled. HLA-DR genotyping was performed with the 
      HLA FluoGene DRDQ kit for each subject. Chi-square tests and t tests were 
      performed for statistical analysis. RESULTS: HLA-DR2 was significantly more 
      frequently found in SLE patients than in controls (odds ratio [OR] = 2.05, 95% 
      CI, 1.44-2.92, p < 0.001). Notably, HLA-DR6 appeared to trend toward negative 
      correlation with SLE, whereas HLA-DR8 appeared to trend toward positive 
      correlation. HLA-DR2 patients had an earlier onset of disease as well as a higher 
      prevalence of oral ulcer, avascular necrosis of bone, and renal involvement 
      (lupus nephritis). CONCLUSION: HLA-DR2 was associated with SLE susceptibility in 
      this Taiwanese population as well as lower age of disease onset and more severe 
      clinical manifestations.
CI  - Copyright (c) 2023, the Chinese Medical Association.
FAU - Yen, Chang-Yi
AU  - Yen CY
AD  - Division of Rheumatology, Department of Internal Medicine, Kaohsiung Medical 
      University Hospital, Kaohsiung, Taiwan, ROC.
AD  - Institute of Medical Informatics, College of Electrical Engineering and Computer 
      Science, National Cheng Kung University, Tainan, Taiwan, ROC.
FAU - Wang, Pin-Yi
AU  - Wang PY
AD  - Division of Rheumatology, Department of Internal Medicine, Kaohsiung Medical 
      University Hospital, Kaohsiung, Taiwan, ROC.
AD  - Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical 
      University, Kaohsiung, Taiwan, ROC.
FAU - Chen, Kuan-Yu
AU  - Chen KY
AD  - Division of Rheumatology, Department of Internal Medicine, Kaohsiung Medical 
      University Hospital, Kaohsiung, Taiwan, ROC.
AD  - Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical 
      University, Kaohsiung, Taiwan, ROC.
FAU - Tseng, Chia-Chun
AU  - Tseng CC
AD  - Division of Rheumatology, Department of Internal Medicine, Kaohsiung Medical 
      University Hospital, Kaohsiung, Taiwan, ROC.
AD  - School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, 
      Taiwan, ROC.
FAU - Wu, Cheng-Chin
AU  - Wu CC
AD  - Division of Rheumatology, Department of Internal Medicine, Kaohsiung Medical 
      University Hospital, Kaohsiung, Taiwan, ROC.
FAU - Ou, Tsan-Teng
AU  - Ou TT
AD  - Division of Rheumatology, Department of Internal Medicine, Kaohsiung Medical 
      University Hospital, Kaohsiung, Taiwan, ROC.
FAU - Yen, Jeng-Hsien
AU  - Yen JH
AD  - Division of Rheumatology, Department of Internal Medicine, Kaohsiung Medical 
      University Hospital, Kaohsiung, Taiwan, ROC.
AD  - Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical 
      University, Kaohsiung, Taiwan, ROC.
AD  - Institute of Biomedical Science, National Sun Yat-Sen University, Kaohsiung, 
      Taiwan, ROC.
AD  - Department of Biomedical Science and Technology, National Yang Ming Chiao Tung 
      University, Hsinchu, Taiwan, ROC.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20231006
PL  - Netherlands
TA  - J Chin Med Assoc
JT  - Journal of the Chinese Medical Association : JCMA
JID - 101174817
RN  - 0 (HLA-DR2 Antigen)
RN  - 0 (HLA-DR Antigens)
SB  - IM
MH  - Humans
MH  - *HLA-DR2 Antigen/genetics
MH  - Taiwan
MH  - Genetic Predisposition to Disease
MH  - HLA-DR Antigens/genetics
MH  - *Lupus Erythematosus, Systemic/genetics
MH  - Genotype
COIS- Conflicts of interest: The authors declare that they have no conflicts of 
      interest related to the subject matter or materials discussed in this article.
EDAT- 2023/10/06 18:42
MHDA- 2023/12/07 12:42
CRDT- 2023/10/06 14:23
PHST- 2023/12/07 12:42 [medline]
PHST- 2023/10/06 18:42 [pubmed]
PHST- 2023/10/06 14:23 [entrez]
AID - 02118582-990000000-00285 [pii]
AID - 10.1097/JCMA.0000000000001009 [doi]
PST - ppublish
SO  - J Chin Med Assoc. 2023 Dec 1;86(12):1060-1065. doi: 
      10.1097/JCMA.0000000000001009. Epub 2023 Oct 6.