PMID- 37802773
OWN - NLM
STAT- MEDLINE
DCOM- 20231009
LR  - 20231018
IS  - 1001-5302 (Print)
IS  - 1001-5302 (Linking)
VI  - 48
IP  - 15
DP  - 2023 Aug
TI  - [Research progress on traditional Chinese medicine in treatment of 
      neurodegenerative diseases by delaying neurovascular unit aging].
PG  - 4060-4071
LID - 10.19540/j.cnki.cjcmm.20230519.601 [doi]
AB  - Neurodegenerative diseases are a collective term for a large group of diseases 
      caused by degenerative changes in nerve cells. Aging is the main risk factor for 
      neurodegenerative diseases. The neurovascular unit(NVU) is the smallest 
      functional unit of the brain, which regulates brain blood flow and maintains 
      brain homeostasis. Accelerated aging of NVU cells directly impairs NVU function 
      and leads to the occurrence of various neurodegenerative diseases. The intrinsic 
      mechanisms of NVU cell aging are complex and involve oxidative stress damage, 
      loss of protein homeostasis, DNA damage, mitochondrial dysfunction, immune 
      inflammatory response, and impaired cellular autophagy. In recent years, studies 
      have found that traditional Chinese medicine(TCM) can inhibit NVU aging through 
      multiple pathways and targets, exerting a brain-protective effect. Therefore, 
      this article aimed to provide a theoretical basis for further research on TCM 
      inhibition of NVU cell aging and references for new drug development and clinical 
      applications by reviewing its mechanisms of anti-aging, such as regulating 
      relevant proteins, improving mitochondrial dysfunction, reducing DNA damage, 
      lowering inflammatory response, antioxidant stress, and modulating cellular 
      autophagy.
FAU - Ying, Chun-Miao
AU  - Ying CM
AD  - Henan University of Chinese Medicine Zhengzhou 450046, China.
FAU - Liu, Fei-Xiang
AU  - Liu FX
AD  - Henan University of Chinese Medicine Zhengzhou 450046, China the First Affiliated 
      Hospital of Henan University of Chinese Medicine Zhengzhou 450000, China.
FAU - Pan, Xiao-Long
AU  - Pan XL
AD  - Henan University of Chinese Medicine Zhengzhou 450046, China.
FAU - Fan, Fei-Yan
AU  - Fan FY
AD  - Henan University of Chinese Medicine Zhengzhou 450046, China.
FAU - Chen, Na
AU  - Chen N
AD  - Henan University of Chinese Medicine Zhengzhou 450046, China.
FAU - Zhang, Yun-Ke
AU  - Zhang YK
AD  - Henan University of Chinese Medicine Zhengzhou 450046, China the First Affiliated 
      Hospital of Henan University of Chinese Medicine Zhengzhou 450000, China.
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhongguo Zhong Yao Za Zhi
JT  - Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese 
      materia medica
JID - 8913656
SB  - IM
MH  - Humans
MH  - *Medicine, Chinese Traditional
MH  - *Neurodegenerative Diseases/drug therapy
MH  - Brain
MH  - Aging
MH  - Neurons
MH  - Blood-Brain Barrier
OTO - NOTNLM
OT  - aging
OT  - neurodegenerative diseases
OT  - neurovascular unit
OT  - traditional Chinese medicine
EDAT- 2023/10/07 00:41
MHDA- 2023/10/09 06:42
CRDT- 2023/10/06 22:03
PHST- 2023/10/09 06:42 [medline]
PHST- 2023/10/07 00:41 [pubmed]
PHST- 2023/10/06 22:03 [entrez]
AID - 10.19540/j.cnki.cjcmm.20230519.601 [doi]
PST - ppublish
SO  - Zhongguo Zhong Yao Za Zhi. 2023 Aug;48(15):4060-4071. doi: 
      10.19540/j.cnki.cjcmm.20230519.601.