PMID- 37803163 OWN - NLM STAT- MEDLINE DCOM- 20231101 LR - 20231118 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 13 IP - 1 DP - 2023 Oct 6 TI - Retinal vascular occlusion risks during the COVID-19 pandemic and after SARS-CoV-2 infection. PG - 16851 LID - 10.1038/s41598-023-44199-z [doi] LID - 16851 AB - The coronavirus disease 2019 (COVID-19) has been reported to affect vascular networks including the eye. However, evidence on the causal relationship between COVID-19 infection and retinal vascular occlusions remains limited. This study aimed to determine the change in retinal vascular occlusion incidence during COVID-19 era and whether severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection induces retinal vascular occlusion. Retinal vein occlusion (RVO) and retinal artery occlusion (RAO) incidences during 2018-2019 and 2020-July 2021 were compared, those in confirmed and suspected COVID-19 patients diagnosed from 2020 to January 2021 were calculated, and those in COVID-19 patients during 180 days prior and 180 days after diagnosis were assessed. Additionally, the standardized incidence ratio of RVOs in COVID-19 patients was analyzed. Incidence rates per 100,000 people/year of RVO during 2018-2019 and 2020-2021 was 102.0 and 98.8, respectively. RAO incidence rates during 2018-2019 and 2020-2021 were 11.7 and 12.0, respectively. In both confirmed and suspected COVID-19 patients, the incidence of RVO and RAO did not change significantly from 180 days before to after diagnosis in the adjusted model. RVO incidence slightly decreased while RAO incidence increased during the COVID-19 pandemic. SARS-CoV-2 infection did not significantly increase RVO or RAO incidence. CI - (c) 2023. Springer Nature Limited. FAU - Park, Hyo Song AU - Park HS AD - Department of Ophthalmology, College of Medicine, Soonchunhyang University, Cheonan, South Korea. AD - Department of Ophthalmology, Soonchunhyang University Hospital Bucheon, Bucheon, South Korea. FAU - Kim, Sunyeup AU - Kim S AD - Department of Medical AI, Sungkyunkwan University School of Medicine, Suwon, South Korea. FAU - Lee, Christopher Seungkyu AU - Lee CS AD - Department of Ophthalmology, The Institute of Vision Research, Yonsei University College of Medicine, Seoul, South Korea. FAU - Byeon, Suk Ho AU - Byeon SH AD - Department of Ophthalmology, The Institute of Vision Research, Yonsei University College of Medicine, Seoul, South Korea. FAU - Kim, Sung Soo AU - Kim SS AD - Department of Ophthalmology, The Institute of Vision Research, Yonsei University College of Medicine, Seoul, South Korea. FAU - Lee, Seung Won AU - Lee SW AD - Department of Precision Medicine, Sungkyunkwan University School of Medicine, Suwon, South Korea. lsw2920@gmail.com. FAU - Kim, Yong Joon AU - Kim YJ AD - Department of Ophthalmology, The Institute of Vision Research, Yonsei University College of Medicine, Seoul, South Korea. kyjcolor@naver.com. AD - Department of Ophthalmology, Institute of Vision Research, Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea. kyjcolor@naver.com. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20231006 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - *COVID-19/epidemiology/complications MH - Pandemics MH - SARS-CoV-2 MH - *Retinal Diseases/complications MH - *Retinal Vein Occlusion/epidemiology/etiology/diagnosis MH - *Retinal Artery Occlusion/epidemiology MH - Risk Factors MH - Incidence PMC - PMC10558568 COIS- The authors declare no competing interests. EDAT- 2023/10/07 00:41 MHDA- 2023/11/01 12:43 PMCR- 2023/10/06 CRDT- 2023/10/06 23:29 PHST- 2023/03/16 00:00 [received] PHST- 2023/10/04 00:00 [accepted] PHST- 2023/11/01 12:43 [medline] PHST- 2023/10/07 00:41 [pubmed] PHST- 2023/10/06 23:29 [entrez] PHST- 2023/10/06 00:00 [pmc-release] AID - 10.1038/s41598-023-44199-z [pii] AID - 44199 [pii] AID - 10.1038/s41598-023-44199-z [doi] PST - epublish SO - Sci Rep. 2023 Oct 6;13(1):16851. doi: 10.1038/s41598-023-44199-z.