PMID- 37804362
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231121
IS  - 2192-2195 (Print)
IS  - 2192-2209 (Electronic)
IS  - 2192-2209 (Linking)
VI  - 13
IP  - 1
DP  - 2023 Oct 7
TI  - Essential oil extracted from Quzhou Aurantii Fructus prevents acute liver failure 
      through inhibiting lipopolysaccharide-mediated inflammatory response.
PG  - 36
LID - 10.1007/s13659-023-00398-9 [doi]
LID - 36
AB  - Quzhou Aurantii Fructus (QAF) has a long history as a folk medicine and food for 
      the treatment of liver diseases. While our earlier study provided evidence of 
      hepatoprotective properties contained within the flavonoids and limonins 
      constituents in QAF, the potential preventative effects afforded by essential oil 
      components present within QAF remains enigmatic. In this study, we prepared 
      Quzhou Aurantii Fructus essential oil (QAFEO) and confirmed its anti-inflammatory 
      effects on liver inflammation through experimentation on lipopolysaccharide and 
      D-galactosamine (LPS/D-GalN) induced acute liver failure (ALF) mouse models. 
      Using RNA-sequence (RNA-seq) analysis, we found that QAFEO prevented ALF by 
      systematically blunting the pathways involved in response to LPS and toll-like 
      receptor signaling pathways. QAFEO effectively suppressed the phosphorylation of 
      tank-binding kinase 1 (TBK1), TGF-beta activated kinase 1 (TAK1), interferon 
      regulatory factor 3 (IRF3), and the activation of mitogen activated kinase-like 
      protein (MAPK) and nuclear factor-kappa B (NF-kappaB) pathways in vivo and in vitro. 
      Importantly, QAFEO substantially reduced myeloid differentiation primary response 
      gene 88 (MyD88)- toll-like receptor 4 (TLR4) interaction levels. Moreover, 8 
      compounds from QAFEO could directly bind to REAL, TAK1, MyD88, TBK1, and IRF3. 
      Taken together, the results of our study support the notion that QAFEO exerts a 
      hepatoprotective effect through inhibiting LPS-mediated inflammatory response.
CI  - (c) 2023. Kunming Institute of Botany, CAS.
FAU - Lan, Tian
AU  - Lan T
AD  - The Joint Innovation Center for Health and Medicine, Quzhou People's Hospital, 
      The Quzhou Affiliated Hospital of Wenzhou Medical University, No. 100 Minjiang 
      Road, Quzhou, 324000, China.
FAU - Wang, Wen
AU  - Wang W
AD  - Preventive Treatment Center, Zhejiang Chinese Medical University Affiliated 
      Four-provinces Marginal Hospital of Traditional Chinese Medicine, Quzhou Hospital 
      of Traditional Chinese Medicine, Quzhou, 324000, China.
FAU - Huang, De-Lian
AU  - Huang DL
AD  - School of Medical Technology and Information Engineering, Zhejiang Chinese 
      Medical University, Hangzhou, 310053, China.
FAU - Zeng, Xi-Xi
AU  - Zeng XX
AD  - The Joint Innovation Center for Health and Medicine, Quzhou People's Hospital, 
      The Quzhou Affiliated Hospital of Wenzhou Medical University, No. 100 Minjiang 
      Road, Quzhou, 324000, China.
FAU - Wang, Xiao-Xiao
AU  - Wang XX
AD  - Department of Drug Analysis Center, Quzhou Institute for Food and Drug Control, 
      Quzhou, 324000, China.
FAU - Wang, Jian
AU  - Wang J
AD  - Department of Drug Analysis Center, Quzhou Institute for Food and Drug Control, 
      Quzhou, 324000, China.
FAU - Tong, Yu-Hua
AU  - Tong YH
AD  - The Joint Innovation Center for Health and Medicine, Quzhou People's Hospital, 
      The Quzhou Affiliated Hospital of Wenzhou Medical University, No. 100 Minjiang 
      Road, Quzhou, 324000, China. yuhuatong@126.com.
AD  - Department of Ophthalmology, Quzhou People's Hospital, The Quzhou Affiliated 
      Hospital of Wenzhou Medical University, Quzhou, 324000, China. yuhuatong@126.com.
FAU - Mao, Zhu-Jun
AU  - Mao ZJ
AD  - Department of Ophthalmology, Quzhou People's Hospital, The Quzhou Affiliated 
      Hospital of Wenzhou Medical University, Quzhou, 324000, China. 
      maozhujun0107@163.com.
AD  - College of Pharmaceutical Sciences, Zhejiang Chinese Medical University, No. 548 
      Binwen Road, Hangzhou, 310053, China. maozhujun0107@163.com.
FAU - Wang, Si-Wei
AU  - Wang SW
AUID- ORCID: 0000-0001-8813-6647
AD  - The Joint Innovation Center for Health and Medicine, Quzhou People's Hospital, 
      The Quzhou Affiliated Hospital of Wenzhou Medical University, No. 100 Minjiang 
      Road, Quzhou, 324000, China. 358031289@qq.com.
AD  - Department of Ophthalmology, Quzhou People's Hospital, The Quzhou Affiliated 
      Hospital of Wenzhou Medical University, Quzhou, 324000, China. 358031289@qq.com.
LA  - eng
GR  - 2021Y004/Quzhou Municipal Science and Technology Bureau/
GR  - 2022K53/Quzhou Municipal Science and Technology Bureau/
GR  - 2020ZA120/Zhejiang Traditional Chinese Medicine Administration/
GR  - 2021013/Fuli Institute of Food Science, Zhejiang University/
PT  - Journal Article
DEP - 20231007
PL  - Germany
TA  - Nat Prod Bioprospect
JT  - Natural products and bioprospecting
JID - 101577734
PMC - PMC10560171
OTO - NOTNLM
OT  - Acute liver failure
OT  - Essential oil
OT  - Inflammation
OT  - LPS
OT  - Quzhou Aurantii Fructus
COIS- The authors declare no conflict of interest.
EDAT- 2023/10/07 16:42
MHDA- 2023/10/07 16:43
PMCR- 2023/10/07
CRDT- 2023/10/07 11:06
PHST- 2023/07/08 00:00 [received]
PHST- 2023/09/11 00:00 [accepted]
PHST- 2023/10/07 16:43 [medline]
PHST- 2023/10/07 16:42 [pubmed]
PHST- 2023/10/07 11:06 [entrez]
PHST- 2023/10/07 00:00 [pmc-release]
AID - 10.1007/s13659-023-00398-9 [pii]
AID - 398 [pii]
AID - 10.1007/s13659-023-00398-9 [doi]
PST - epublish
SO  - Nat Prod Bioprospect. 2023 Oct 7;13(1):36. doi: 10.1007/s13659-023-00398-9.