PMID- 37807729
OWN - NLM
STAT- MEDLINE
DCOM- 20231101
LR  - 20240210
IS  - 1533-0338 (Electronic)
IS  - 1533-0346 (Print)
IS  - 1533-0338 (Linking)
VI  - 22
DP  - 2023 Jan-Dec
TI  - Predictive Value of the Neutrophil-Lymphocyte Ratio for Tumor Regression Grade 
      and Prognosis of Local Advanced Rectal Cancer Patients Undergoing Neoadjuvant 
      Chemoradiotherapy.
PG  - 15330338231202611
LID - 10.1177/15330338231202611 [doi]
LID - 15330338231202611
AB  - PURPOSE: Numerous indicators can be used to predict tumor patients' prognosis and 
      tumor regression grade (TRG). The role of the neutrophil-lymphocyte ratio (NLR) 
      among individuals with locally advanced rectal cancer (LARC) following 
      neoadjuvant chemoradiotherapy (nCRT) hasn't been studied, nevertheless. This 
      study aims to explore the predictive value of the NLR before nCRT (pre-NLR) in 
      TRG and prognosis of LARC patients undergoing nCRT.. METHODS: In this 
      retrospective investigation, 326 LARC patients receiving nCRT in total were 
      included. The link between the pre-NLR and TRG was examined using a logistic 
      regression analysis. A Cox-based nomogram was created in the meanwhile to 
      forecast overall survival (OS). With the use of calibration plots and receiver 
      operating characteristic (ROC) curves, we evaluated the nomogram's predictive 
      capabilities. RESULTS: The median pre-NLR across 326 patients was 2.2 
      (interquartile range, IQR: 1.7-2.7). In the logistic regression analysis, only 
      the pre-NLR for TRG in LARC patients receiving nCRT was statistically significant 
      (odds ratio, OR = 0.62, 95% CI: 0.47-0.80, P < 0.001). Pre-NLR, nCRT with surgery 
      interval, ypTNM stage, TRG, vascular invasion, adjuvant chemotherapy, and 
      carbohydrate antigen 19-9 before nCRT were revealed to be OS predictors in the 
      Cox multivariate analysis. According to calibration plots and ROC curves, the 
      predictive nomogram demonstrated high statistical performance on internal 
      validation. CONCLUSION: This study demonstrated that a lower pre-NLR was probably 
      associated with a greater rate of TRG in LARC patients undergoing nCRT. 
      Furthermore, the pre-NLR was credibly correlated with OS in LARC patients 
      undergoing nCRT. Meanwhile, we constructed a nomogram for predicting the 
      prognosis in LARC patients undergoing nCRT.
FAU - Li, Shuofeng
AU  - Li S
AD  - National Cancer Center/National Clinical Research Center for Cancer/Cancer 
      Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 
      Beijing, P.R. China.
FAU - Wang, Dingyuan
AU  - Wang D
AUID- ORCID: 0000-0002-4858-6253
AD  - National Cancer Center/National Clinical Research Center for Cancer/Cancer 
      Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 
      Beijing, P.R. China.
FAU - Wei, Ran
AU  - Wei R
AD  - National Cancer Center/National Clinical Research Center for Cancer/Cancer 
      Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 
      Beijing, P.R. China.
FAU - Yu, Guanhua
AU  - Yu G
AD  - National Cancer Center/National Clinical Research Center for Cancer/Cancer 
      Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 
      Beijing, P.R. China.
FAU - Wang, Xishan
AU  - Wang X
AD  - National Cancer Center/National Clinical Research Center for Cancer/Cancer 
      Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 
      Beijing, P.R. China.
FAU - Jiang, Zheng
AU  - Jiang Z
AUID- ORCID: 0000-0002-1369-3681
AD  - National Cancer Center/National Clinical Research Center for Cancer/Cancer 
      Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 
      Beijing, P.R. China.
LA  - eng
GR  - CC2016/ARC_/Arthritis Research UK/United Kingdom
PT  - Journal Article
PL  - United States
TA  - Technol Cancer Res Treat
JT  - Technology in cancer research & treatment
JID - 101140941
SB  - IM
MH  - Humans
MH  - *Neoadjuvant Therapy
MH  - Neutrophils/pathology
MH  - Retrospective Studies
MH  - Prognosis
MH  - *Rectal Neoplasms/pathology
MH  - Lymphocytes/pathology
MH  - Chemoradiotherapy
PMC - PMC10563499
OTO - NOTNLM
OT  - local advanced rectal cancer
OT  - neoadjuvant chemoradiotherapy
OT  - neutrophil-lymphocyte ratio
OT  - prognostic factor
OT  - tumor regression grade
COIS- Declaration of Conflicting InterestsThe authors declared no potential conflicts 
      of interest with respect to the research, authorship, and/or publication of this 
      article.
EDAT- 2023/10/09 06:42
MHDA- 2023/11/01 12:45
PMCR- 2023/10/09
CRDT- 2023/10/09 03:36
PHST- 2023/11/01 12:45 [medline]
PHST- 2023/10/09 06:42 [pubmed]
PHST- 2023/10/09 03:36 [entrez]
PHST- 2023/10/09 00:00 [pmc-release]
AID - 10.1177_15330338231202611 [pii]
AID - 10.1177/15330338231202611 [doi]
PST - ppublish
SO  - Technol Cancer Res Treat. 2023 Jan-Dec;22:15330338231202611. doi: 
      10.1177/15330338231202611.