PMID- 37807767
OWN - NLM
STAT- MEDLINE
DCOM- 20231023
LR  - 20231024
IS  - 2050-7518 (Electronic)
IS  - 2050-750X (Linking)
VI  - 11
IP  - 40
DP  - 2023 Oct 18
TI  - Preparation and performance of a stimuli-responsive drug delivery system: novel 
      light-triggered temperature-sensitive drug-loaded microcapsules.
PG  - 9757-9764
LID - 10.1039/d3tb01836a [doi]
AB  - Stimuli-responsive/smart drug delivery systems (DDSs), particularly those that 
      use temperature as a stimuli-response factor to activate drug release, are the 
      subject of recent research. A phase change material (PCM) is a popular thermally 
      responsive material that can be used as a drug carrier and only when the system 
      temperature is above the phase change point is the drug released following the 
      phase change material changing from solid to liquid. In this study, a novel NIR 
      light-triggered temperature-sensitive drug delivery system is developed for 
      controllable release of acyclovir (ACV). For this purpose, a mixture of a phase 
      change material (T38) and an ACV compound is first emulsified with copper oxide 
      nanoparticles (CuO NPs) as a Pickering stabilizer and a photothermal conversion 
      material, and then encapsulated with SiO(2) to form a photothermal 
      stimuli-responsive delivery system. This system shows a uniform spherical shape 
      with a well-distinct core-shell structure, and is further experimentally proven 
      to be able to controllably release drugs with solid-liquid transition of the 
      phase change carrier upon temperature change. These results indicate that 
      cumulative release of ACV can reach 51.2% at 40  degrees C within 20 hours, which is much 
      higher than 27.3% release achieved below the melting point of T38. In addition, 
      CuO NPs with excellent photothermal conversion ability endow the system with 
      precisely controllable drug delivery via NIR light stimulation, where the 
      cumulative drug release can reach 83.6% after 7 cycles of light stimulation, 
      allowing controlled release at a specific time or location.
FAU - Chen, Zhengguo
AU  - Chen Z
AUID- ORCID: 0009-0001-1795-2038
AD  - School of Materials Science and Engineering, Zhejiang Sci-Tech University, 
      Hangzhou 310018, China. zgq@zstu.edu.cn.
FAU - Zhou, Wangting
AU  - Zhou W
AD  - School of Materials Science and Engineering, Zhejiang Sci-Tech University, 
      Hangzhou 310018, China. zgq@zstu.edu.cn.
FAU - Wei, Yujing
AU  - Wei Y
AD  - School of Materials Science and Engineering, Zhejiang Sci-Tech University, 
      Hangzhou 310018, China. zgq@zstu.edu.cn.
FAU - Shi, Lingling
AU  - Shi L
AD  - School of Materials Science and Engineering, Zhejiang Sci-Tech University, 
      Hangzhou 310018, China. zgq@zstu.edu.cn.
FAU - Zhang, Zhaoxia
AU  - Zhang Z
AD  - School of Materials Science and Engineering, Zhejiang Sci-Tech University, 
      Hangzhou 310018, China. zgq@zstu.edu.cn.
FAU - Dadgar, Mehran
AU  - Dadgar M
AD  - Department of Textile, University of Neyshabur, Adib Boulevard, Khorasan Razavi 
      Province, Iran.
FAU - Zhu, Guocheng
AU  - Zhu G
AD  - School of Materials Science and Engineering, Zhejiang Sci-Tech University, 
      Hangzhou 310018, China. zgq@zstu.edu.cn.
FAU - Zhang, Guoqing
AU  - Zhang G
AUID- ORCID: 0000-0002-2871-0659
AD  - School of Materials Science and Engineering, Zhejiang Sci-Tech University, 
      Hangzhou 310018, China. zgq@zstu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20231018
PL  - England
TA  - J Mater Chem B
JT  - Journal of materials chemistry. B
JID - 101598493
RN  - V1XJQ704R4 (cupric oxide)
RN  - 0 (Capsules)
RN  - 7631-86-9 (Silicon Dioxide)
RN  - 80168379AG (Doxorubicin)
SB  - IM
MH  - Temperature
MH  - Capsules
MH  - *Silicon Dioxide
MH  - *Doxorubicin/chemistry
MH  - Drug Delivery Systems/methods
EDAT- 2023/10/09 06:41
MHDA- 2023/10/23 01:18
CRDT- 2023/10/09 03:43
PHST- 2023/10/23 01:18 [medline]
PHST- 2023/10/09 06:41 [pubmed]
PHST- 2023/10/09 03:43 [entrez]
AID - 10.1039/d3tb01836a [doi]
PST - epublish
SO  - J Mater Chem B. 2023 Oct 18;11(40):9757-9764. doi: 10.1039/d3tb01836a.