PMID- 37808894
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231031
IS  - 2328-8957 (Print)
IS  - 2328-8957 (Electronic)
IS  - 2328-8957 (Linking)
VI  - 10
IP  - 10
DP  - 2023 Oct
TI  - Safety of Single High-Dose Liposomal Amphotericin B for Induction Treatment of 
      Cryptococcal Meningitis and Histoplasmosis in People With HIV: A Systematic 
      Review and Meta-analysis.
PG  - ofad472
LID - 10.1093/ofid/ofad472 [doi]
LID - ofad472
AB  - BACKGROUND: Evidence for efficacy of single, high-dose liposomal amphotericin B 
      (LAmB) in HIV-associated cryptococcal meningitis and histoplasmosis is growing. 
      No systematic review has examined the safety of this regimen across multiple 
      studies. METHODS: We systematically searched Medline, Scopus, and the Cochrane 
      Library from inception to April 2023 for studies reporting grade 3 and 4 adverse 
      events (AEs) with single high-dose LAmB vs traditional amphotericin regimens for 
      HIV-associated fungal infections. RESULTS: Three trials (n = 946) were included. 
      Compared with traditional regimens, single high-dose LAmB was associated with 
      equivalent risk of grade 3 and 4 AEs (risk ratio [RR], 0.75; 95% CI, 0.53-1.06) 
      and lower overall risk of grade 4 AEs (RR, 0.68; 95% CI, 0.55-0.86), grade 4 
      renal (RR, 0.43; 95% CI, 0.20-0.94) and grade 4 hematological AEs (RR, 0.46; 95% 
      CI, 0.32-0.65). CONCLUSIONS: Single, high-dose LAmB is associated with a lower 
      risk of life-threatening AEs compared with other World Health 
      Organization-endorsed amphotericin B-based regimens in invasive HIV-related 
      fungal infection.
CI  - (c) The Author(s) 2023. Published by Oxford University Press on behalf of 
      Infectious Diseases Society of America.
FAU - Kang, HeeEun
AU  - Kang H
AUID- ORCID: 0009-0000-9794-9666
AD  - Infectious Disease and International Health, Department of Medicine, Dartmouth 
      Hitchcock Medical Center, Lebanon, New Hampshire, USA.
AD  - Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.
FAU - Uy, John P
AU  - Uy JP
AD  - Infectious Disease and International Health, Department of Medicine, Dartmouth 
      Hitchcock Medical Center, Lebanon, New Hampshire, USA.
AD  - Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.
FAU - Ho, Caroline C
AU  - Ho CC
AD  - Infectious Disease and International Health, Department of Medicine, Dartmouth 
      Hitchcock Medical Center, Lebanon, New Hampshire, USA.
AD  - Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.
FAU - Blunt, Heather B
AU  - Blunt HB
AD  - Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.
FAU - Riblet, Natalie B
AU  - Riblet NB
AD  - Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.
FAU - Pasqualotto, Alessandro C
AU  - Pasqualotto AC
AD  - Infectious Diseases, Universidade Federal de Ciencias da Saude de Porto Alegre, 
      Porto Alegre, Brazil.
FAU - Murphy, Richard A
AU  - Murphy RA
AD  - Infectious Disease and International Health, Department of Medicine, Dartmouth 
      Hitchcock Medical Center, Lebanon, New Hampshire, USA.
AD  - Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.
AD  - White River Junction VA Medical Center, Hartford, Vermont, USA.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20230920
PL  - United States
TA  - Open Forum Infect Dis
JT  - Open forum infectious diseases
JID - 101637045
PMC - PMC10551850
OTO - NOTNLM
OT  - HIV infection
OT  - antifungal
OT  - cryptococcal meningitis
OT  - histoplasmosis
OT  - opportunistic infections
COIS- Potential conflicts of interest. All authors: no reported conflicts.
EDAT- 2023/10/09 06:41
MHDA- 2023/10/09 06:42
PMCR- 2023/09/20
CRDT- 2023/10/09 05:47
PHST- 2023/07/24 00:00 [received]
PHST- 2023/09/13 00:00 [accepted]
PHST- 2023/10/09 06:42 [medline]
PHST- 2023/10/09 06:41 [pubmed]
PHST- 2023/10/09 05:47 [entrez]
PHST- 2023/09/20 00:00 [pmc-release]
AID - ofad472 [pii]
AID - 10.1093/ofid/ofad472 [doi]
PST - epublish
SO  - Open Forum Infect Dis. 2023 Sep 20;10(10):ofad472. doi: 10.1093/ofid/ofad472. 
      eCollection 2023 Oct.