PMID- 37808975
OWN - NLM
STAT- MEDLINE
DCOM- 20231102
LR  - 20231102
IS  - 2296-2565 (Electronic)
IS  - 2296-2565 (Linking)
VI  - 11
DP  - 2023
TI  - The causal relationship between gut microbiota and type 2 diabetes: a two-sample 
      Mendelian randomized study.
PG  - 1255059
LID - 10.3389/fpubh.2023.1255059 [doi]
LID - 1255059
AB  - BACKGROUND: Type 2 diabetes mellitus (T2DM) is a commonly observed metabolic 
      anomaly globally, and as of the present time, there's no recognized solution. 
      There is an increasing body of evidence from numerous observational studies 
      indicating a significant correlation between gut flora and metabolic disease 
      progression, particularly in relation to T2DM. Despite this, the direct impact of 
      gut microbiota on T2DM isn't fully understood yet. METHODS: The summary 
      statistical figures for intestinal microbiota were sourced from the MiBioGen 
      consortium, while the summary statistical data for T2DM were gathered from the 
      Genome-Wide Association Studies (GWAS) database. These datasets were used to 
      execute a two-sample Mendelian randomization (MR) investigation. The Inverse 
      Variance Weighted (IVW), Maximum Likelihood, MR-Egger, Weighted Median, and 
      Weighted Models strategies were employed to assess the impact of gut microbiota 
      on T2DM. Findings were primarily obtained using the IVW technique. Techniques 
      like MR-Egger were employed to identify the occurrence of horizontal pleiotropy 
      among instrumental variables. Meanwhile, Cochran's Q statistical measures were 
      utilized to assess the variability or heterogeneity within these instrumental 
      variables. RESULTS: The outcomes from the IVW analysis demonstrated that the 
      genus Alistipes (OR = 0.998, 95% confidence interval: 0.996-1.000, and P = 
      0.038), genus Allisonella (OR = 0.998, 95% confidence interval: 0.997-0.999, P = 
      0.033), genus Flavonifractor (OR = 0.995, 95% confidence interval: 0.993-0.998, P 
      = 3.78 x 10(-3)), and genus Haemophilus (OR = 0.995, 95% confidence interval: 
      0.993-0.998, P = 8.08 x 10(-3)) all acted as defense elements against type 2 
      diabetes. Family Clostridiaceae1 (OR = 1.003, 95% confidence interval: 
      1.001-1.005, P = 0.012), family Coriobacteriaceae (OR = 1.0025, 95% confidence 
      interval: 1.000-1.005, P = 0.043), genus Actinomyces (OR = 1.003,95% confidence 
      interval: 1.001-1.005, P = 4.38 x 10(-3)), genus Candidatus Soleaferrea (OR = 
      1.001,95% confidence interval: 1.000-1.002 P = 0.012) were risk factors for type 
      2 diabetes. False Discovery Rate correction was performed with finding that 
      genus.Allisonella, genus.Alistipes, family Coriobacteriaceaeand T2DM no longer 
      displayed a significant causal association. In addition, no significant 
      heterogeneity or horizontal pleiotropy was found for instrumental variable. 
      CONCLUSION: This MR study relies on genetic variation tools to confirm the causal 
      effect of genus Flavonifractor, genus Haemophilus, family Clostridiaceae1, genus 
      Actinomyces and genus Candidatus Soleaferrea on T2DM in the gut microbiome, 
      providing new directions and strategies for the treatment and early screening of 
      T2DM, which carries significant clinical relevance. To develop new biomarkers and 
      better understand targeted prevention strategies for T2DM, further comprehensive 
      investigations are required into the protective and detrimental mechanisms 
      exerted by these five genera against T2DM.
CI  - Copyright (c) 2023 Sun, Gao, Wu and Huang.
FAU - Sun, Kewang
AU  - Sun K
AD  - School of Medical Laboratory, Weifang Medical College, Weifang, China.
AD  - Department of Blood Transfusion, The 960th Hospital of the PLA Jonit Logistics 
      Support Force, Jinan, China.
FAU - Gao, Yan
AU  - Gao Y
AD  - Department of General Medicine, The 960th Hospital of the PLA Jonit Logistics 
      Support Force, Jinan, China.
FAU - Wu, Huaqing
AU  - Wu H
AD  - School of Mathematics and Statistics, Beijing Technology and Business University, 
      Beijing, China.
FAU - Huang, Xiangyan
AU  - Huang X
AD  - Department of Blood Transfusion, The 960th Hospital of the PLA Jonit Logistics 
      Support Force, Jinan, China.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20230922
PL  - Switzerland
TA  - Front Public Health
JT  - Frontiers in public health
JID - 101616579
SB  - IM
MH  - Humans
MH  - Clinical Relevance
MH  - *Diabetes Mellitus, Type 2/genetics
MH  - *Gastrointestinal Microbiome/genetics
MH  - Genome-Wide Association Study
MH  - Risk Factors
MH  - Mendelian Randomization Analysis
PMC - PMC10556527
OTO - NOTNLM
OT  - Mendelian randomized study
OT  - causal inference
OT  - genetic variation
OT  - gut microbiota
OT  - type 2 diabetes
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2023/10/09 06:42
MHDA- 2023/11/01 12:45
PMCR- 2023/09/22
CRDT- 2023/10/09 05:49
PHST- 2023/07/08 00:00 [received]
PHST- 2023/09/04 00:00 [accepted]
PHST- 2023/11/01 12:45 [medline]
PHST- 2023/10/09 06:42 [pubmed]
PHST- 2023/10/09 05:49 [entrez]
PHST- 2023/09/22 00:00 [pmc-release]
AID - 10.3389/fpubh.2023.1255059 [doi]
PST - epublish
SO  - Front Public Health. 2023 Sep 22;11:1255059. doi: 10.3389/fpubh.2023.1255059. 
      eCollection 2023.