PMID- 37809324 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20231030 IS - 2296-858X (Print) IS - 2296-858X (Electronic) IS - 2296-858X (Linking) VI - 10 DP - 2023 TI - Fatty infiltration of the pancreas: a systematic concept analysis. PG - 1227188 LID - 10.3389/fmed.2023.1227188 [doi] LID - 1227188 AB - Fatty infiltration of the pancreas (FIP) has been recognized for nearly a century, yet many aspects of this condition remain unclear. Regular literature reviews on the diagnosis, consequences, and management of FIP are crucial. This review article highlights the various disorders for which FIP has been established as a risk factor, including type 2 diabetes mellitus (T2DM), pancreatitis, pancreatic fistula (PF), metabolic syndrome (MS), polycystic ovary syndrome (PCOS), and pancreatic duct adenocarcinoma (PDAC), as well as the new investigation tools. Given the interdisciplinary nature of FIP research, a broad range of healthcare specialists are involved. This review article covers key aspects of FIP, including nomenclature and definition of pancreatic fat infiltration, history and epidemiology, etiology and pathophysiology, clinical presentation and diagnosis, clinical consequences, and treatment. This review is presented in a detailed narrative format for accessibility to clinicians and medical students. CI - Copyright (c) 2023 Mahyoub, Elhoumed, Maqul, Almezgagi, Abbas, Jiao, Wang, Alnaggar, Zhao and He. FAU - Mahyoub, Mueataz A AU - Mahyoub MA AD - Department of Gastroenterology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China. AD - Clinical Medical Research Center for Digestive Diseases (Oncology) of Shaanxi Province, Xi'an, China. AD - Department of Gastroenterology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China. AD - Department of Gastroenterology, Faculty of Medicine, Thamar University, Dhamar, Yemen. FAU - Elhoumed, Mohamed AU - Elhoumed M AD - Department of Epidemiology and Biostatistics, School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, China. AD - National Institute of Public Health Research (INRSP), Nouakchott, Mauritania. FAU - Maqul, Abdulfatah Hassan AU - Maqul AH AD - Department of Medical Imaging, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China. AD - Department of Medical Imaging, Sahan Diagnostic Center, Mogadishu, Somalia. FAU - Almezgagi, Maged AU - Almezgagi M AD - The Key Laboratory of High-altitude Medical Application of Qinghai Province, Xining, Qinghai, China. AD - Department of Immunology, Qinghai University, Xining, Qinghai, China. AD - Department of Medical Microbiology, Faculty of Sciences, Ibb University, Ibb, Yemen. FAU - Abbas, Mustafa AU - Abbas M AD - Department of Internal Medicine, Faculty of Medicine, Thamar University, Dhamar, Yemen. FAU - Jiao, Yang AU - Jiao Y AD - Department of Endocrinology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China. FAU - Wang, Jinhai AU - Wang J AD - Department of Gastroenterology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China. FAU - Alnaggar, Mohammed AU - Alnaggar M AD - Department of Oncology, South Hubei Cancer Hospital, Xianning, Hubei, China. AD - Department of Internal Medicine, Clinic Medical College, Hubei University of Science and Technology, Xianning, Hubei, China. FAU - Zhao, Ping AU - Zhao P AD - Department of Gastroenterology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China. FAU - He, Shuixiang AU - He S AD - Department of Gastroenterology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China. AD - Clinical Medical Research Center for Digestive Diseases (Oncology) of Shaanxi Province, Xi'an, China. LA - eng PT - Journal Article PT - Review DEP - 20230922 PL - Switzerland TA - Front Med (Lausanne) JT - Frontiers in medicine JID - 101648047 PMC - PMC10556874 OTO - NOTNLM OT - fatty infiltration of the pancreas OT - metabolic syndrome OT - obesity OT - pancreatic duct adenocarcinoma OT - type 2 diabetes mellitus COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2023/10/09 06:41 MHDA- 2023/10/09 06:42 PMCR- 2023/09/22 CRDT- 2023/10/09 05:53 PHST- 2023/05/22 00:00 [received] PHST- 2023/08/30 00:00 [accepted] PHST- 2023/10/09 06:42 [medline] PHST- 2023/10/09 06:41 [pubmed] PHST- 2023/10/09 05:53 [entrez] PHST- 2023/09/22 00:00 [pmc-release] AID - 10.3389/fmed.2023.1227188 [doi] PST - epublish SO - Front Med (Lausanne). 2023 Sep 22;10:1227188. doi: 10.3389/fmed.2023.1227188. eCollection 2023.