PMID- 37811328
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231018
IS  - 1662-4548 (Print)
IS  - 1662-453X (Electronic)
IS  - 1662-453X (Linking)
VI  - 17
DP  - 2023
TI  - Altered intrinsic functional brain architecture in patients with functional 
      constipation: a surface-based network study.
PG  - 1241993
LID - 10.3389/fnins.2023.1241993 [doi]
LID - 1241993
AB  - BACKGROUND: Functional constipation (FCon) is a common functional 
      gastrointestinal disorder (FGID). Studies have indicated a higher likelihood of 
      psychiatric disorders, such as anxiety, depression, sleep disturbances, and 
      impaired concentration, among patients with FCon. However, the underlying 
      pathophysiological mechanisms responsible for these symptoms in FCon patients 
      remain to be fully elucidated. The human brain is a complex network architecture 
      with several fundamental organizational properties. Neurological interactions 
      between gut symptoms and psychiatric issues may be closely associated with these 
      complex networks. METHODS: In the present study, a total of 35 patients with FCon 
      and 40 healthy controls (HC) were recruited for a series of clinical examinations 
      and resting-state functional magnetic imaging (RS-fMRI). We employed the 
      surface-based analysis (SBA) approach, utilizing the Schaefer cortical 
      parcellation template and Tikhonov regularization. Graph theoretical analysis 
      (GTA) and functional connectivity (FC) analysis of RS-fMRI were conducted to 
      investigate the aberrant network alterations between the two groups. 
      Additionally, correlation analyses were performed between the network indices and 
      clinical variables in patients with FCon. RESULTS: At the global level, we found 
      altered topological properties and networks in patients with FCon, mainly 
      including the significantly increased clustering coefficient (C(P)), local 
      efficiency (E(loc)), and shortest path length (L(P)), whereas the decreased 
      global efficiency (E(glob)) compared to HC. At the regional level, patients with 
      FCon exhibited increased nodal efficiency in the frontoparietal network (FPN). 
      Furthermore, FC analysis demonstrated several functional alterations within and 
      between the Yeo 7 networks, particularly including visual network (VN), limbic 
      network (LN), default mode network (DMN), and somatosensory-motor network (SMN) 
      in sub-network and large-scale network analysis. Correlation analysis revealed 
      that there were no significant associations between the network metrics and 
      clinical variables in the present study. CONCLUSION: These results highlight the 
      altered topological architecture of functional brain networks associated with 
      visual perception abilities, emotion regulation, sensorimotor processing, and 
      attentional control, which may contribute to effectively targeted treatment 
      modalities for patients with FCon.
CI  - Copyright (c) 2023 Yu, Yu, Li, Cong, Wang, Fan, Wang, Zhou, Xu, Li and Liu.
FAU - Yu, Xiang
AU  - Yu X
AD  - Department of Radiology, Tianjin Union Medical Center, Tianjin, China.
FAU - Yu, Jingjie
AU  - Yu J
AD  - Department of Psychiatry and Psychology, Tianjin Union Medical Center, Tianjin, 
      China.
FAU - Li, Yuwei
AU  - Li Y
AD  - Department of Colorectal Surgery, Tianjin Union Medical Center, Tianjin, China.
FAU - Cong, Jiying
AU  - Cong J
AD  - Department of Colorectal Surgery, Tianjin Union Medical Center, Tianjin, China.
FAU - Wang, Chao
AU  - Wang C
AD  - Department of Radiology, Tianjin Union Medical Center, Tianjin, China.
FAU - Fan, Ran
AU  - Fan R
AD  - Department of Radiology, Tianjin Union Medical Center, Tianjin, China.
FAU - Wang, Wanbing
AU  - Wang W
AD  - Graduate School of Tianjin Nankai University, Tianjin, China.
FAU - Zhou, Lige
AU  - Zhou L
AD  - Graduate School of Tianjin Medical University, Tianjin, China.
FAU - Xu, Chen
AU  - Xu C
AD  - Department of Colorectal Surgery, Tianjin Union Medical Center, Tianjin, China.
FAU - Li, Yiming
AU  - Li Y
AD  - Department of Radiology, Tianjin Union Medical Center, Tianjin, China.
FAU - Liu, Yawu
AU  - Liu Y
AD  - Department of Neurology, University of Eastern Finland, Kuopio, Finland.
AD  - Department of Clinical Radiology, Kuopio University Hospital, Kuopio, Finland.
LA  - eng
PT  - Journal Article
DEP - 20230921
PL  - Switzerland
TA  - Front Neurosci
JT  - Frontiers in neuroscience
JID - 101478481
PMC - PMC10551127
OTO - NOTNLM
OT  - functional connectivity
OT  - functional constipation
OT  - graph theoretical analysis
OT  - resting-state fMRI
OT  - surface-based analysis
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2023/10/09 12:43
MHDA- 2023/10/09 12:44
PMCR- 2023/01/01
CRDT- 2023/10/09 06:15
PHST- 2023/06/18 00:00 [received]
PHST- 2023/09/06 00:00 [accepted]
PHST- 2023/10/09 12:44 [medline]
PHST- 2023/10/09 12:43 [pubmed]
PHST- 2023/10/09 06:15 [entrez]
PHST- 2023/01/01 00:00 [pmc-release]
AID - 10.3389/fnins.2023.1241993 [doi]
PST - epublish
SO  - Front Neurosci. 2023 Sep 21;17:1241993. doi: 10.3389/fnins.2023.1241993. 
      eCollection 2023.