PMID- 37812943 OWN - NLM STAT- MEDLINE DCOM- 20231103 LR - 20231113 IS - 1872-7123 (Electronic) IS - 0165-1781 (Linking) VI - 329 DP - 2023 Nov TI - Duration of untreated prodromal psychosis among individuals with clinical high risk for psychosis. PG - 115522 LID - S0165-1781(23)00472-9 [pii] LID - 10.1016/j.psychres.2023.115522 [doi] AB - The impact of the duration of untreated psychosis on the outcomes of schizophrenia has been extensively studied. However, there is a notable gap in the current understanding of the relationship between the duration of untreated prodromal symptoms (DUPrS) and the development of psychosis in individuals at clinical high risk (CHR). A sample of 704 individuals with CHR was identified through a structured interview, of who 145 (20.6 %) converted to psychosis (CHR-C) during the 3-year follow-up. The DUPrS was defined as the period between the onset of the first attenuated psychotic positive symptom and the commencement of professional assistance at mental health services. Quantile regression was applied for quantile levels between 0.1 and 0.9, and adjusted for age, sex, and education.The overall sample had a mean DUPrS of 7.1 months. No significant differences were observed in the DUPrS between the CHR-C and non-converter (CHR-NC) groups. Quantile regression analysis highlighted variations in the effects of the DUPrS on clinical variables across the different quantiles. We observed a positive association between DUPrS rank and positive symptoms below the 0.3 quantile, while a positive association between DUPrS rank and negative symptoms above the 0.3 quantile (except 0.7 and 0.9 quantile). A longer DUPrS (> 3 months) was associated with younger age (odds ratio [OR] = 0.948, p = 0.003), a higher proportion of women (OR = 1.474, p = 0.003), higher baseline global function (OR = 1.044, p = 0.003), lower previous global function (OR = 0.921, p < 0.001), and higher negative symptoms (OR = 1.061, p = 0.001). This study sheds light on the pivotal role of DUPrS as a potential intermediary factor in the complex pathway of psychosis. CI - Copyright (c) 2023 Elsevier B.V. All rights reserved. FAU - Zhang, TianHong AU - Zhang T AD - Shanghai Mental Health Center, Shanghai Engineering Research Center of Intelligent Psychological Evaluation and Intervention, Shanghai Key Laboratory of Psychotic Disorders, Shanghai Jiaotong University School of Medicine, 600 Wanping Nan Road, Shanghai 200030, PR China. FAU - Xu, LiHua AU - Xu L AD - Shanghai Mental Health Center, Shanghai Engineering Research Center of Intelligent Psychological Evaluation and Intervention, Shanghai Key Laboratory of Psychotic Disorders, Shanghai Jiaotong University School of Medicine, 600 Wanping Nan Road, Shanghai 200030, PR China. FAU - Wei, YanYan AU - Wei Y AD - Shanghai Mental Health Center, Shanghai Engineering Research Center of Intelligent Psychological Evaluation and Intervention, Shanghai Key Laboratory of Psychotic Disorders, Shanghai Jiaotong University School of Medicine, 600 Wanping Nan Road, Shanghai 200030, PR China. FAU - Tang, XiaoChen AU - Tang X AD - Shanghai Mental Health Center, Shanghai Engineering Research Center of Intelligent Psychological Evaluation and Intervention, Shanghai Key Laboratory of Psychotic Disorders, Shanghai Jiaotong University School of Medicine, 600 Wanping Nan Road, Shanghai 200030, PR China. FAU - Hu, YeGang AU - Hu Y AD - Shanghai Mental Health Center, Shanghai Engineering Research Center of Intelligent Psychological Evaluation and Intervention, Shanghai Key Laboratory of Psychotic Disorders, Shanghai Jiaotong University School of Medicine, 600 Wanping Nan Road, Shanghai 200030, PR China. FAU - Cui, HuiRu AU - Cui H AD - Shanghai Mental Health Center, Shanghai Engineering Research Center of Intelligent Psychological Evaluation and Intervention, Shanghai Key Laboratory of Psychotic Disorders, Shanghai Jiaotong University School of Medicine, 600 Wanping Nan Road, Shanghai 200030, PR China. FAU - Tang, YingYing AU - Tang Y AD - Shanghai Mental Health Center, Shanghai Engineering Research Center of Intelligent Psychological Evaluation and Intervention, Shanghai Key Laboratory of Psychotic Disorders, Shanghai Jiaotong University School of Medicine, 600 Wanping Nan Road, Shanghai 200030, PR China. FAU - Wang, ZiXuan AU - Wang Z AD - Shanghai Xinlianxin Psychological Counseling Co., Ltd, Shanghai, PR China. FAU - Liu, HaiChun AU - Liu H AD - Department of Automation, Shanghai Jiao Tong University, Shanghai 200240, PR China. FAU - Chen, Tao AU - Chen T AD - Big Data Research Lab, University of Waterloo, Ontario, Canada; Senior Research Fellow, Labor and Worklife Program, Harvard University, Cambridge, MA, United States. FAU - Li, ChunBo AU - Li C AD - Shanghai Mental Health Center, Shanghai Engineering Research Center of Intelligent Psychological Evaluation and Intervention, Shanghai Key Laboratory of Psychotic Disorders, Shanghai Jiaotong University School of Medicine, 600 Wanping Nan Road, Shanghai 200030, PR China. FAU - Wang, JiJun AU - Wang J AD - Shanghai Mental Health Center, Shanghai Engineering Research Center of Intelligent Psychological Evaluation and Intervention, Shanghai Key Laboratory of Psychotic Disorders, Shanghai Jiaotong University School of Medicine, 600 Wanping Nan Road, Shanghai 200030, PR China; Center for Excellence in Brain Science and Intelligence Technology (CEBSIT), Chinese Academy of Science, Shanghai, PR China; Institute of Psychology and Behavioral Science, Shanghai Jiao Tong University, Shanghai, PR China. Electronic address: jijunwang27@163.com. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20231006 PL - Ireland TA - Psychiatry Res JT - Psychiatry research JID - 7911385 SB - IM MH - Humans MH - Female MH - Infant MH - *Psychotic Disorders/psychology MH - *Schizophrenia/diagnosis MH - *Mental Health Services MH - Educational Status MH - Prodromal Symptoms OTO - NOTNLM OT - Duration of untreated psychosis OT - Psychosis OT - Schizophrenia OT - Transition OT - Ultra high risk COIS- Declaration of Competing Interest None. EDAT- 2023/10/10 00:42 MHDA- 2023/11/03 06:44 CRDT- 2023/10/09 18:34 PHST- 2023/08/20 00:00 [received] PHST- 2023/09/29 00:00 [revised] PHST- 2023/09/29 00:00 [accepted] PHST- 2023/11/03 06:44 [medline] PHST- 2023/10/10 00:42 [pubmed] PHST- 2023/10/09 18:34 [entrez] AID - S0165-1781(23)00472-9 [pii] AID - 10.1016/j.psychres.2023.115522 [doi] PST - ppublish SO - Psychiatry Res. 2023 Nov;329:115522. doi: 10.1016/j.psychres.2023.115522. Epub 2023 Oct 6.