PMID- 37813138
OWN - NLM
STAT- MEDLINE
DCOM- 20231130
LR  - 20240207
IS  - 1096-0953 (Electronic)
IS  - 0013-9351 (Print)
IS  - 0013-9351 (Linking)
VI  - 239
IP  - Pt 1
DP  - 2023 Dec 15
TI  - Associations of per- and polyfluoroalkyl substances, polychlorinated biphenyls, 
      organochlorine pesticides, and polybrominated diphenyl ethers with oxidative 
      stress markers: A systematic review and meta-analysis.
PG  - 117308
LID - S0013-9351(23)02112-6 [pii]
LID - 10.1016/j.envres.2023.117308 [doi]
AB  - BACKGROUND: Per- and polyfluoroalkyl substances (PFAS), polychlorinated biphenyls 
      (PCBs), organochlorine pesticides (OCPs), and polybrominated diphenyl ethers 
      (PBDEs) are intentionally produced persistent organic pollutants (POPs) that are 
      resistant to environmental degradation. Previous in-vitro and in-vivo studies 
      have shown that POPs can induce oxidative stress, which is linked to 
      neurodegenerative diseases, cardiovascular diseases, and cancer. However, 
      findings in epidemiological studies are inconsistent and an evidence synthesis 
      study is lacking to summarize the existing literature and explore research gaps. 
      OBJECTIVE: We evaluated the effects of PFAS, PCBs, OCPs, and PBDEs, on oxidative 
      stress biomarkers in epidemiological studies. METHODS: A literature search was 
      conducted in PubMed, Embase, and Cochrane CENTRAL to identify all published 
      studies related to POPs and oxidative stress up to December 7(th), 2022. We 
      included human observational studies reporting at least one exposure to POPs and 
      an oxidative stress biomarker of interest. Random-effects meta-analyses on 
      standardized regression coefficients and effect direction plots with one-tailed 
      sign tests were used for quantitative synthesis. RESULTS: We identified 33 
      studies on OCPs, 35 on PCBs, 49 on PFAS, and 12 on PBDEs. Meta-analyses revealed 
      significant positive associations of alpha-HCH with protein carbonyls (0.035 [0.017, 
      0.054]) and of 4'4-DDE with malondialdehyde (0.121 [0.056, 0.187]), as well as a 
      significant negative association between 2'4-DDE and total antioxidant capacity 
      (TAC) (-0.042 [-0.079, -0.004]), all beta [95%CI]. Sign tests showed a significant 
      positive association between PCBs and malondialdehyde (p(one-tailed) = 0.03). 
      Additionally, we found significant negative associations of OCPs with 
      acetylcholine esterase (p(one-tailed) = 0.02) and paraoxonase-1 
      (p(one-tailed) = 0.03). However, there were inconsistent associations of OCPs 
      with superoxide dismutase, glutathione peroxidase, and catalase. CONCLUSIONS: 
      Higher levels of OCPs were associated with increased levels of oxidative stress 
      through increased pro-oxidant biomarkers involving protein oxidation, DNA damage, 
      and lipid peroxidation, as well as decreased TAC. These findings have the 
      potential to reveal the underlying mechanisms of POPs toxicity.
CI  - Copyright (c) 2023 Elsevier Inc. All rights reserved.
FAU - Chen, Jiawen Carmen
AU  - Chen JC
AD  - Department of Population and Public Health Sciences, University of Southern 
      California Keck School of Medicine, Los Angeles, CA, United States. Electronic 
      address: chenjiaw@usc.edu.
FAU - Baumert, Brittney O
AU  - Baumert BO
AD  - Department of Population and Public Health Sciences, University of Southern 
      California Keck School of Medicine, Los Angeles, CA, United States.
FAU - Li, Yijie
AU  - Li Y
AD  - Department of Population and Public Health Sciences, University of Southern 
      California Keck School of Medicine, Los Angeles, CA, United States.
FAU - Li, Yiping
AU  - Li Y
AD  - Department of Population and Public Health Sciences, University of Southern 
      California Keck School of Medicine, Los Angeles, CA, United States.
FAU - Pan, Shudi
AU  - Pan S
AD  - Department of Population and Public Health Sciences, University of Southern 
      California Keck School of Medicine, Los Angeles, CA, United States.
FAU - Robinson, Shante
AU  - Robinson S
AD  - University of Southern California, Los Angeles, CA, United States.
FAU - Rubbo, Bruna
AU  - Rubbo B
AD  - Department of Population and Public Health Sciences, University of Southern 
      California Keck School of Medicine, Los Angeles, CA, United States.
FAU - Costello, Elizabeth
AU  - Costello E
AD  - Department of Population and Public Health Sciences, University of Southern 
      California Keck School of Medicine, Los Angeles, CA, United States.
FAU - He, Jie
AU  - He J
AD  - School of Public Health, University of Michigan, Ann Arbor, MI, United States.
FAU - Hampson, Hailey
AU  - Hampson H
AD  - Department of Population and Public Health Sciences, University of Southern 
      California Keck School of Medicine, Los Angeles, CA, United States.
FAU - Beglarian, Emily
AU  - Beglarian E
AD  - Department of Population and Public Health Sciences, University of Southern 
      California Keck School of Medicine, Los Angeles, CA, United States.
FAU - Rock, Sarah
AU  - Rock S
AD  - Department of Population and Public Health Sciences, University of Southern 
      California Keck School of Medicine, Los Angeles, CA, United States.
FAU - Goodrich, Jesse A
AU  - Goodrich JA
AD  - Department of Population and Public Health Sciences, University of Southern 
      California Keck School of Medicine, Los Angeles, CA, United States.
FAU - Eckel, Sandrah P
AU  - Eckel SP
AD  - Department of Population and Public Health Sciences, University of Southern 
      California Keck School of Medicine, Los Angeles, CA, United States.
FAU - Aung, Max T
AU  - Aung MT
AD  - Department of Population and Public Health Sciences, University of Southern 
      California Keck School of Medicine, Los Angeles, CA, United States.
FAU - McConnell, Rob
AU  - McConnell R
AD  - Department of Population and Public Health Sciences, University of Southern 
      California Keck School of Medicine, Los Angeles, CA, United States.
FAU - Conti, David V
AU  - Conti DV
AD  - Department of Population and Public Health Sciences, University of Southern 
      California Keck School of Medicine, Los Angeles, CA, United States.
FAU - Chatzi, Lida
AU  - Chatzi L
AD  - Department of Population and Public Health Sciences, University of Southern 
      California Keck School of Medicine, Los Angeles, CA, United States.
LA  - eng
GR  - R21 ES029681/ES/NIEHS NIH HHS/United States
GR  - R01 ES030691/ES/NIEHS NIH HHS/United States
GR  - P2C ES033433/ES/NIEHS NIH HHS/United States
GR  - R01 ES030364/ES/NIEHS NIH HHS/United States
GR  - T32 ES013678/ES/NIEHS NIH HHS/United States
GR  - P01 CA196569/CA/NCI NIH HHS/United States
GR  - R01 ES029944/ES/NIEHS NIH HHS/United States
GR  - P30 ES007048/ES/NIEHS NIH HHS/United States
PT  - Journal Article
PT  - Meta-Analysis
PT  - Systematic Review
DEP - 20231007
PL  - Netherlands
TA  - Environ Res
JT  - Environmental research
JID - 0147621
RN  - 0 (Antioxidants)
RN  - 0 (Biomarkers)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Fluorocarbons)
RN  - 0 (Halogenated Diphenyl Ethers)
RN  - 0 (Hydrocarbons, Chlorinated)
RN  - 4Y8F71G49Q (Malondialdehyde)
RN  - 0 (Pesticides)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Humans
MH  - Antioxidants
MH  - Biomarkers
MH  - *Environmental Pollutants/toxicity
MH  - *Fluorocarbons/toxicity
MH  - Halogenated Diphenyl Ethers/toxicity
MH  - *Hydrocarbons, Chlorinated/toxicity
MH  - Malondialdehyde
MH  - Oxidative Stress
MH  - *Pesticides/toxicity
MH  - *Polychlorinated Biphenyls/toxicity
PMC - PMC10841434
MID - NIHMS1938064
OTO - NOTNLM
OT  - OCPs
OT  - PBDEs
OT  - PCBs
OT  - PFAS
OT  - Persistent organic pollutants
OT  - oxidative stress
COIS- Declaration of competing interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2023/10/10 00:42
MHDA- 2023/11/21 06:42
PMCR- 2024/12/15
CRDT- 2023/10/09 19:19
PHST- 2023/03/27 00:00 [received]
PHST- 2023/09/09 00:00 [revised]
PHST- 2023/10/03 00:00 [accepted]
PHST- 2024/12/15 00:00 [pmc-release]
PHST- 2023/11/21 06:42 [medline]
PHST- 2023/10/10 00:42 [pubmed]
PHST- 2023/10/09 19:19 [entrez]
AID - S0013-9351(23)02112-6 [pii]
AID - 10.1016/j.envres.2023.117308 [doi]
PST - ppublish
SO  - Environ Res. 2023 Dec 15;239(Pt 1):117308. doi: 10.1016/j.envres.2023.117308. 
      Epub 2023 Oct 7.