PMID- 37814218
OWN - NLM
STAT- MEDLINE
DCOM- 20231031
LR  - 20231031
IS  - 1520-510X (Electronic)
IS  - 0020-1669 (Linking)
VI  - 62
IP  - 42
DP  - 2023 Oct 23
TI  - Green Synthesis of Carboxymethyl Chitosan-Based CuInS(2) QDs with Luminescent 
      Response toward Pb(2+) Ion and Its Application in Bioimaging.
PG  - 17486-17498
LID - 10.1021/acs.inorgchem.3c02901 [doi]
AB  - Polysaccharide-based QDs have attracted great attention in the field of 
      biological imaging and diagnostics. How to get rid of the high heavy metal 
      toxicity resulting from conventional Cd- and Pb-based QDs is now the main 
      challenge. Herein, we offer a simple and environmentally friendly approach for 
      the "direct" interaction of thiol-ending carboxymethyl chitosan (CMC-SH) with 
      metal salt precursors, resulting in CuInS(2) QDs based on polysaccharides. A 
      nucleation-growth mechanism based on the LaMer model can explain how CMC-CuInS(2) 
      QDs are formed. As-prepared water-soluble CMC-CuInS(2) QDs exhibit monodisperse 
      particles with sizes of 5.5-6.5 nm. CMC-CuInS(2) QDs emit the bright-green 
      fluorescence at 530 nm when excited at 466 nm with the highest quantum yield of 
       approximately 18.0%. Meanwhile, the fluorescence intensity of CMC-CuInS(2) QD aqueous solution 
      is quenched with the addition of Pb(2+) and the minimal limit of detection is as 
      little as 0.4 nM. Furthermore, due to its noncytotoxicity, great 
      biocompatibility, and strong biorecognition ability, CMC-CuInS(2) QDs can be 
      exploited as a possible cell membrane imaging reagent. The imaging studies also 
      demonstrate that CMC-CuInS(2) QDs are suitable for Pb(2+) detection in live cells 
      and living organisms (zebrafish). Thus, this work offers such an efficient, 
      green, and practical method for creating low-toxicity and water-soluble QD 
      nanosensors for a sensitive and selective detection of toxic metal ion in live 
      cells and organisms.
FAU - Guan, Xiaolin
AU  - Guan X
AUID- ORCID: 0000-0002-1537-406X
AD  - Key Laboratory of Eco-Environment-Related Polymer Materials Ministry of 
      Education, Key Laboratory of Polymer Materials Ministry of Gansu Province, 
      College of Chemistry and Chemical Engineering, Northwest Normal University, 
      Lanzhou 730070, China.
FAU - Zhang, Jiaming
AU  - Zhang J
AD  - Key Laboratory of Eco-Environment-Related Polymer Materials Ministry of 
      Education, Key Laboratory of Polymer Materials Ministry of Gansu Province, 
      College of Chemistry and Chemical Engineering, Northwest Normal University, 
      Lanzhou 730070, China.
FAU - Lai, Shoujun
AU  - Lai S
AD  - College of Chemical Engineering, Lanzhou University of Arts and Science, Lanzhou 
      730000, China.
FAU - Wang, Kang
AU  - Wang K
AD  - Key Laboratory of Eco-Environment-Related Polymer Materials Ministry of 
      Education, Key Laboratory of Polymer Materials Ministry of Gansu Province, 
      College of Chemistry and Chemical Engineering, Northwest Normal University, 
      Lanzhou 730070, China.
FAU - Zhang, Wentao
AU  - Zhang W
AD  - Key Laboratory of Eco-Environment-Related Polymer Materials Ministry of 
      Education, Key Laboratory of Polymer Materials Ministry of Gansu Province, 
      College of Chemistry and Chemical Engineering, Northwest Normal University, 
      Lanzhou 730070, China.
FAU - Han, Yang
AU  - Han Y
AD  - Key Laboratory of Eco-Environment-Related Polymer Materials Ministry of 
      Education, Key Laboratory of Polymer Materials Ministry of Gansu Province, 
      College of Chemistry and Chemical Engineering, Northwest Normal University, 
      Lanzhou 730070, China.
FAU - Fan, Yuwen
AU  - Fan Y
AD  - Key Laboratory of Eco-Environment-Related Polymer Materials Ministry of 
      Education, Key Laboratory of Polymer Materials Ministry of Gansu Province, 
      College of Chemistry and Chemical Engineering, Northwest Normal University, 
      Lanzhou 730070, China.
FAU - Li, Chenghao
AU  - Li C
AD  - Key Laboratory of Traditional Chinese Medicine Prevention and Treatment, Gansu 
      University of Traditional Chinese Medicine, Lanzhou 730000, China.
FAU - Tong, Jinhui
AU  - Tong J
AD  - Key Laboratory of Eco-Environment-Related Polymer Materials Ministry of 
      Education, Key Laboratory of Polymer Materials Ministry of Gansu Province, 
      College of Chemistry and Chemical Engineering, Northwest Normal University, 
      Lanzhou 730070, China.
LA  - eng
PT  - Journal Article
DEP - 20231009
PL  - United States
TA  - Inorg Chem
JT  - Inorganic chemistry
JID - 0366543
RN  - 2P299V784P (Lead)
RN  - 9012-76-4 (Chitosan)
RN  - 059QF0KO0R (Water)
SB  - IM
MH  - Animals
MH  - *Quantum Dots/toxicity
MH  - Lead/toxicity
MH  - *Chitosan
MH  - Zebrafish
MH  - Water
EDAT- 2023/10/10 00:42
MHDA- 2023/10/31 06:42
CRDT- 2023/10/09 23:41
PHST- 2023/10/31 06:42 [medline]
PHST- 2023/10/10 00:42 [pubmed]
PHST- 2023/10/09 23:41 [entrez]
AID - 10.1021/acs.inorgchem.3c02901 [doi]
PST - ppublish
SO  - Inorg Chem. 2023 Oct 23;62(42):17486-17498. doi: 10.1021/acs.inorgchem.3c02901. 
      Epub 2023 Oct 9.