PMID- 37814879
OWN - NLM
STAT- MEDLINE
DCOM- 20231011
LR  - 20231018
IS  - 1673-4254 (Print)
IS  - 2663-0842 (Electronic)
IS  - 1673-4254 (Linking)
VI  - 43
IP  - 9
DP  - 2023 Sep 20
TI  - [Changes of brain network in patients with insomnia following radiotherapy for 
      cervical cancer and their correlation with IT-TMS treatment efficacy: a 
      graph-theory analysis].
PG  - 1629-1635
LID - 10.12122/j.issn.1673-4254.2023.09.22 [doi]
AB  - OBJECTIVE: To analyze the changes of brain small-world and node function network 
      properties in patients with insomnia following radiotherapy for cervical cancer 
      based on graph theory analysis and explore the correlation between functional 
      networks and the clinical efficacy of individual-target transcranial magnetic 
      stimulation (IT-TMS) for treatment of insomnia. METHODS: The resting state 
      functional magnetic resonance imaging (rs-fMRI) data were collected from 30 
      patients with insomnia following radiotherapy for cervical cancer and 30 matched 
      healthy individuals. All the patients received accelerated intelligent 
      neuromodulation TMS therapy. Using graph theory analysis and GRETNA software, the 
      functional connectivity matrices were constructed and the attribute features were 
      extracted. The scores on the Pittsburgh Sleep Quality Index (PSQI), Insomnia 
      Severity Index (ISI), Self-Rating Anxiety Scale (SAS), and Self-Rating Depression 
      Scale (SDS) of the participants were collected before and after IT-TMS, and the 
      correlation between improvement in insomnia and the functional network was 
      investigated. RESULTS: The two groups matched for age, gender, and education 
      level (P>0.05) showed significant differences in PSQI, ISI, SAS and SDS scores 
      (P<0.05). Both groups showed attributes of the small-world network. Compared with 
      the healthy individuals, the patients showed significantly decreased sigma, EI, Cp 
      and Lp (P<0.05) and increased Eg (P<0.05) at baseline, which, along with insomnia 
      symptoms, were all improved after IT-TMS treatment. The patients showed reduced 
      functional connections of the node network at follow-up compared with the 
      baseline, and the low functional connectivity between the right insula and left 
      superior frontal gyrus was correlated with the improvement of ISI scores. 
      CONCLUSION: The patients with insomnia following radiotherapy for cervical cancer 
      have impaired information integration ability of the brain network, IT-TMS can 
      significantly improve insomnia symptoms by reducing the hyperconnectivity between 
      the default mode network and the salience network.
FAU - Liu, H
AU  - Liu H
AD  - School of Mathematics and Statistics, Xi'an Jiaotong University, Xi'an 710049, 
      China.
FAU - Rao, Y
AU  - Rao Y
AD  - Shaanxi Brain Modulation and Scientific Research Center, Xi'an 710075, China.
FAU - Sun, C
AU  - Sun C
AD  - Shaanxi Brain Modulation and Scientific Research Center, Xi'an 710075, China.
FAU - Wang, Y
AU  - Wang Y
AD  - Shaanxi Brain Modulation and Scientific Research Center, Xi'an 710075, China.
FAU - Qi, S
AU  - Qi S
AD  - Shaanxi Brain Modulation and Scientific Research Center, Xi'an 710075, China.
AD  - Research Center for Brain-Inspired Intelligence, Xi'an Jiaotong University, Xi'an 
      710049, China.
FAU - Li, X
AU  - Li X
AD  - School of Life Science and Technology//Institute of Health and Rehabilitation 
      Science//The Key Laboratory of Biomedical Information Engineering of Ministry of 
      Education, Xi'an Jiaotong University, Xi'an 710049, China.
FAU - Tian, M
AU  - Tian M
AD  - Mi Shi Internal Medicine, Shaanxi Academy of Traditional Chinese Medicine, Xi'an 
      710003, China.
FAU - Yu, X
AU  - Yu X
AD  - Shaanxi Brain Modulation and Scientific Research Center, Xi'an 710075, China.
FAU - Mu, Y
AU  - Mu Y
AD  - Department of Gynecological Oncology, Shaanxi Provincial Cancer Hospital, Xi'an 
      710065, China.
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Nan Fang Yi Ke Da Xue Xue Bao
JT  - Nan fang yi ke da xue xue bao = Journal of Southern Medical University
JID - 101266132
SB  - IM
MH  - Female
MH  - Humans
MH  - *Sleep Initiation and Maintenance Disorders/etiology/therapy
MH  - Transcranial Magnetic Stimulation
MH  - *Uterine Cervical Neoplasms/radiotherapy
MH  - Brain Mapping/methods
MH  - Magnetic Resonance Imaging/methods
MH  - Brain
PMC - PMC10563105
OTO - NOTNLM
OT  - cervical cancer
OT  - graph theory analysis
OT  - individual-transcranial magnetic stimulation
OT  - insomnia
OT  - radiotherapy
OT  - small-world network
EDAT- 2023/10/10 06:42
MHDA- 2023/10/11 06:46
PMCR- 2023/09/20
CRDT- 2023/10/10 05:26
PHST- 2023/10/11 06:46 [medline]
PHST- 2023/10/10 06:42 [pubmed]
PHST- 2023/10/10 05:26 [entrez]
PHST- 2023/09/20 00:00 [pmc-release]
AID - nfykdxxb-43-9-1629 [pii]
AID - 10.12122/j.issn.1673-4254.2023.09.22 [doi]
PST - ppublish
SO  - Nan Fang Yi Ke Da Xue Xue Bao. 2023 Sep 20;43(9):1629-1635. doi: 
      10.12122/j.issn.1673-4254.2023.09.22.