PMID- 37814964
OWN - NLM
STAT- MEDLINE
DCOM- 20240215
LR  - 20240215
IS  - 1423-0410 (Electronic)
IS  - 0042-9007 (Linking)
VI  - 119
IP  - 2
DP  - 2024 Feb
TI  - Safety and protection of plasma donors: A scoping review and evidence gap map.
PG  - 110-120
LID - 10.1111/vox.13544 [doi]
AB  - BACKGROUND AND OBJECTIVES: As part of a large-scale project to safely increase 
      plasma collection in Europe, the current scoping review identifies the existing 
      evidence (gaps) on adverse events (AEs) and other health effects in 
      plasmapheresis donors, as well as factors that may be associated with such 
      events/effects. MATERIALS AND METHODS: We searched six databases and three 
      registries. Study characteristics (publication type, language, study design, 
      population, outcomes, associated factors, time of assessment, duration of 
      follow-up, number and frequency of donations, convalescent plasma [y/n], setting 
      and location) were synthesized narratively and in an interactive evidence gap map 
      (EGM). RESULTS: Ninety-four research articles and five registrations were 
      identified. Around 90% were observational studies (57 controlled and 33 
      uncontrolled), and most of them were performed in Europe (55%) or the United 
      States (20%). Factors studied in association with donor health included donor 
      characteristics (e.g., sex, age) (n = 27), cumulative number of donations 
      (n = 21), donation frequency (n = 11), plasma collection device or programme 
      (n = 11), donor status (first time vs. repeat) (n = 10), donation volume per 
      session (n = 8), time in donation programme (n = 3), preventive measures (n = 2) 
      or other (n = 9). CONCLUSION: The current scoping review provides an accessible 
      tool for researchers and policymakers to identify the available evidence (gaps) 
      concerning plasmapheresis donation safety. Controlled prospective studies with 
      long-term donor follow-up are scarce. Furthermore, additional experimental 
      studies comparing the health effects of different donation frequencies are 
      required to inform a safe upper limit for donation frequency.
CI  - (c) 2023 International Society of Blood Transfusion.
FAU - Schroyens, Natalie
AU  - Schroyens N
AD  - Centre for Evidence-Based Practice, Belgian Red Cross, Mechelen, Belgium.
AD  - Department of Public Health and Primary Care, KU Leuven, Leuven, Belgium.
FAU - D'aes, Tine
AU  - D'aes T
AUID- ORCID: 0000-0001-5081-780X
AD  - Centre for Evidence-Based Practice, Belgian Red Cross, Mechelen, Belgium.
FAU - De Buck, Emmy
AU  - De Buck E
AUID- ORCID: 0000-0003-4498-9781
AD  - Centre for Evidence-Based Practice, Belgian Red Cross, Mechelen, Belgium.
AD  - Department of Public Health and Primary Care, KU Leuven, Leuven, Belgium.
FAU - Mikkelsen, Susan
AU  - Mikkelsen S
AD  - Department of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark.
FAU - Tiberghien, Pierre
AU  - Tiberghien P
AUID- ORCID: 0000-0002-9310-8322
AD  - Etablissement Francais du Sang, Saint-Denis, France.
AD  - Universite de Franche-Comte, EFS, INSERM, UMR Right, Besancon, France.
FAU - van den Hurk, Katja
AU  - van den Hurk K
AUID- ORCID: 0000-0003-3241-6003
AD  - Donor Medicine Research - Donor Studies, Sanquin Research, Amsterdam, The 
      Netherlands.
AD  - Department of Public and Occupational Health, Amsterdam Public Health research 
      institute, Amsterdam UMC, Amsterdam, The Netherlands.
FAU - Erikstrup, Christian
AU  - Erikstrup C
AD  - Department of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark.
AD  - Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
FAU - Compernolle, Veerle
AU  - Compernolle V
AD  - Belgian Red Cross, Blood Services, Mechelen, Belgium.
AD  - Faculty of Medicine and Health Sciences, University of Ghent, Ghent, Belgium.
FAU - Van Remoortel, Hans
AU  - Van Remoortel H
AUID- ORCID: 0000-0003-1942-1799
AD  - Centre for Evidence-Based Practice, Belgian Red Cross, Mechelen, Belgium.
AD  - Department of Public Health and Primary Care, KU Leuven, Leuven, Belgium.
LA  - eng
GR  - 101056988/EU4Health Programme by the European Union/
GR  - Foundation for Scientific Research of the Belgian Red Cross/
PT  - Journal Article
PT  - Review
DEP - 20231010
PL  - England
TA  - Vox Sang
JT  - Vox sanguinis
JID - 0413606
SB  - IM
MH  - Humans
MH  - Prospective Studies
MH  - *Evidence Gaps
MH  - *Plasmapheresis/adverse effects
MH  - Blood Donors
MH  - Europe
OTO - NOTNLM
OT  - adverse events
OT  - health effects
OT  - plasma donor
OT  - plasmapheresis
OT  - safety
EDAT- 2023/10/10 12:42
MHDA- 2024/02/15 06:42
CRDT- 2023/10/10 06:40
PHST- 2023/09/13 00:00 [revised]
PHST- 2023/07/25 00:00 [received]
PHST- 2023/09/17 00:00 [accepted]
PHST- 2024/02/15 06:42 [medline]
PHST- 2023/10/10 12:42 [pubmed]
PHST- 2023/10/10 06:40 [entrez]
AID - 10.1111/vox.13544 [doi]
PST - ppublish
SO  - Vox Sang. 2024 Feb;119(2):110-120. doi: 10.1111/vox.13544. Epub 2023 Oct 10.