PMID- 37817259
OWN - NLM
STAT- MEDLINE
DCOM- 20231012
LR  - 20231122
IS  - 1743-422X (Electronic)
IS  - 1743-422X (Linking)
VI  - 20
IP  - 1
DP  - 2023 Oct 10
TI  - A dual role for adeno-associated virus in human health.
PG  - 228
LID - 10.1186/s12985-023-02196-8 [doi]
LID - 228
AB  - Adeno-associated virus (AAV) differs from most other viruses, as it requires the 
      simultaneous presence of a helper virus for an active infection. Up to 80% of the 
      human population is seropositive for AAV antibodies. AAV has been known to be a 
      non-pathogenic virus and an inhibitor of carcinogenesis caused by coinfecting 
      viruses. However, the recent reports associating AAV infection with 
      hepatocellular carcinoma development and the mysterious cases of acute severe 
      hepatitis in children have challenged the idea that AAV is a harmless virus. 
      Herein, we explore the usefulness of AAV in gene therapy and the importance of 
      AAV as a protector or perpetrator in human carcinogenesis, ultimately reflecting 
      on the dual role of AAV in human health.
CI  - (c) 2023. BioMed Central Ltd., part of Springer Nature.
FAU - Araujo, Natalia M
AU  - Araujo NM
AD  - Laboratory of Molecular Virology and Parasitology, Oswaldo Cruz Institute, 
      FIOCRUZ, Rio de Janeiro, RJ, Brazil. nmaraujo@ioc.fiocruz.br.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20231010
PL  - England
TA  - Virol J
JT  - Virology journal
JID - 101231645
SB  - IM
MH  - Child
MH  - Humans
MH  - *Dependovirus/genetics
MH  - Virus Replication
MH  - Helper Viruses/genetics
MH  - *Liver Neoplasms
MH  - Carcinogenesis
PMC - PMC10563340
OTO - NOTNLM
OT  - AAV
OT  - Children
OT  - Gene therapy
OT  - Hepatitis
OT  - Hepatocellular carcinoma
COIS- The author declares no conflict of interest.
EDAT- 2023/10/11 06:45
MHDA- 2023/10/12 06:43
PMCR- 2023/10/10
CRDT- 2023/10/11 00:02
PHST- 2023/08/22 00:00 [received]
PHST- 2023/09/29 00:00 [accepted]
PHST- 2023/10/12 06:43 [medline]
PHST- 2023/10/11 06:45 [pubmed]
PHST- 2023/10/11 00:02 [entrez]
PHST- 2023/10/10 00:00 [pmc-release]
AID - 10.1186/s12985-023-02196-8 [pii]
AID - 2196 [pii]
AID - 10.1186/s12985-023-02196-8 [doi]
PST - epublish
SO  - Virol J. 2023 Oct 10;20(1):228. doi: 10.1186/s12985-023-02196-8.