PMID- 37817641
OWN - NLM
STAT- MEDLINE
DCOM- 20240403
LR  - 20240403
IS  - 1939-022X (Electronic)
IS  - 1939-0211 (Linking)
VI  - 21
IP  - 3
DP  - 2024
TI  - The Effects of Ginger (Zingiber Officinale Roscoe) on Non-Alcoholic Fatty Liver 
      Disease in Patients with Type 2 Diabetes Mellitus: A Randomized Double-Blinded 
      Placebo-Controlled Clinical Trial.
PG  - 294-312
LID - 10.1080/19390211.2023.2263788 [doi]
AB  - Nonalcoholic fatty liver disease (NAFLD) is a prominent etiological factor for 
      liver cirrhosis worldwide. It is frequently associated with obesity, diabetes, 
      dyslipidemia, and hypertension. The objective of this study is to assess the 
      efficacy and safety of ginger (Zingiber officinale Roscoe) supplementation in 
      patients with type 2 diabetes mellitus (T2DM) who have NAFLD. In a two-arm, 
      double-blind, placebo-controlled clinical trial, seventy-six patients diagnosed 
      with both T2DM and NAFLD were randomly assigned to receive either ginger powder 
      capsules (1000 mg, twice daily) or placebo capsules (administered in the same 
      manner) for a period of three months. Anthropometric measurements, blood pressure 
      readings, biochemical profiles, and imaging parameters were assessed before and 
      after the intervention. Safety measures were also evaluated. In both the ginger 
      and placebo groups, there was a significant reduction in mean body mass index 
      (BMI), waist and hip circumferences, as well as liver transaminase levels. 
      Moreover, significant improvements in mean systolic and diastolic blood pressures 
      were observed in the ginger group (p = 0.02 and < 0.0001, respectively). Within 
      the ginger group, there was a decrease in serum insulin levels and insulin 
      resistance (HOMA-IR) (p = 0.002 and 0.004, respectively). Furthermore, the ginger 
      group exhibited an improvement in serum HDL-cholesterol level (p = 0.01). 
      However, there were no significant changes in the assessed inflammatory markers 
      or the indices obtained from fibroscan imaging, including steatosis percent and 
      controlled attenuation parameter. This study demonstrates that ginger 
      supplementation can significantly improve mean systolic and diastolic blood 
      pressures. However, it does not have a significant impact on inflammatory markers 
      or fibroscan imaging indices. Nonetheless, the three-month use of ginger improves 
      serum insulin level, insulin resistance (HOMA-IR), and HDL-cholesterol level 
      compared to baseline values. Further investigations with longer durations and 
      larger sample sizes are recommended.
FAU - Ghoreishi, Parissa Sadat
AU  - Ghoreishi PS
AD  - Research Center for Traditional Medicine and History of Medicine, Department of 
      Persian Medicine, School of Medicine, Shiraz University of Medical Sciences, 
      Shiraz, Iran.
FAU - Shams, Mesbah
AU  - Shams M
AUID- ORCID: 0000-0002-3210-0159
AD  - Endocrine and Metabolism Research Center, Shiraz University of Medical Sciences, 
      Shiraz, Iran.
FAU - Nimrouzi, Majid
AU  - Nimrouzi M
AUID- ORCID: 0000-0003-4630-2082
AD  - Research Center for Traditional Medicine and History of Medicine, Department of 
      Persian Medicine, School of Medicine, Shiraz University of Medical Sciences, 
      Shiraz, Iran.
FAU - Zarshenas, Mohammad M
AU  - Zarshenas MM
AD  - Medicinal Plants Processing Research Center, School of Pharmacy, Shiraz 
      University of Medical Sciences, Shiraz, Iran.
AD  - Department of Phytopharmaceuticals (Traditional Pharmacy), School of Pharmacy, 
      Shiraz University of Medical Sciences, Shiraz, Iran.
FAU - Lankarani, Kamran Bagheri
AU  - Lankarani KB
AD  - Health Policy Research Center, Institute of Health, Shiraz University of Medical 
      Sciences, Shiraz, Iran.
FAU - Fallahzadeh Abarghooei, Ebrahim
AU  - Fallahzadeh Abarghooei E
AD  - Research Center for Traditional Medicine and History of Medicine, Department of 
      Persian Medicine, School of Medicine, Shiraz University of Medical Sciences, 
      Shiraz, Iran.
FAU - Talebzadeh, Mozaffar
AU  - Talebzadeh M
AD  - Independent Gastroenterologist.
FAU - Hashempur, Mohammad Hashem
AU  - Hashempur MH
AUID- ORCID: 0000-0002-6700-9304
AD  - Research Center for Traditional Medicine and History of Medicine, Department of 
      Persian Medicine, School of Medicine, Shiraz University of Medical Sciences, 
      Shiraz, Iran.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20231011
PL  - England
TA  - J Diet Suppl
JT  - Journal of dietary supplements
JID - 101249830
RN  - 97C5T2UQ7J (Cholesterol)
RN  - 0 (Insulins)
SB  - IM
MH  - Humans
MH  - *Non-alcoholic Fatty Liver Disease/drug therapy
MH  - *Diabetes Mellitus, Type 2/complications/drug therapy
MH  - *Zingiber officinale
MH  - *Insulin Resistance
MH  - Double-Blind Method
MH  - Cholesterol
MH  - *Insulins/therapeutic use
OTO - NOTNLM
OT  - Diabetes mellitus
OT  - Ginger
OT  - Herbal medicine
OT  - Nonalcoholic fatty liver disease
OT  - Traditional Persian medicine
OT  - Zingiber officinale
EDAT- 2023/10/11 06:45
MHDA- 2024/04/03 06:44
CRDT- 2023/10/11 03:34
PHST- 2024/04/03 06:44 [medline]
PHST- 2023/10/11 06:45 [pubmed]
PHST- 2023/10/11 03:34 [entrez]
AID - 10.1080/19390211.2023.2263788 [doi]
PST - ppublish
SO  - J Diet Suppl. 2024;21(3):294-312. doi: 10.1080/19390211.2023.2263788. Epub 2023 
      Oct 11.