PMID- 37817767 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20231018 IS - 2234-943X (Print) IS - 2234-943X (Electronic) IS - 2234-943X (Linking) VI - 13 DP - 2023 TI - Pre-clinical lung squamous cell carcinoma mouse models to identify novel biomarkers and therapeutic interventions. PG - 1260411 LID - 10.3389/fonc.2023.1260411 [doi] LID - 1260411 AB - Primary lung carcinoma or lung cancer (LC) is classified into small-cell or non-small-cell (NSCLC) lung carcinoma. Lung squamous cell carcinoma (LSCC) is the second most common subtype of NSCLC responsible for 30% of all LCs, and its survival remains low with only 24% of patients living for five years or longer post-diagnosis primarily due to the advanced stage of tumors at the time of diagnosis. The pathogenesis of LSCC is still poorly understood and has hampered the development of effective diagnostics and therapies. This review highlights the known risk factors, genetic and epigenetic alterations, miRNA biomarkers linked to the development and diagnosis of LSCC and the lack of therapeutic strategies to target specifically LSCC. We will also discuss existing animal models of LSCC including carcinogen induced, transgenic and xenograft mouse models, and their advantages and limitations along with the chemopreventive studies and molecular studies conducted using them. The importance of developing new and improved mouse models will also be discussed that will provide further insights into the initiation and progression of LSCC, and enable the identification of new biomarkers and therapeutic targets. CI - Copyright (c) 2023 Sahu, Donovan, Paudel, Pickles, Chimankar, Kim, Horvart, Dua, Ieni, Nucera, Bielefeldt-Ohmann, Mazilli, Caramori, Lyons and Hansbro. FAU - Sahu, Priyanka AU - Sahu P AD - Immune Health, Hunter Medical Research Institute, University of Newcastle, Newcastle, NSW, Australia. FAU - Donovan, Chantal AU - Donovan C AD - Immune Health, Hunter Medical Research Institute, University of Newcastle, Newcastle, NSW, Australia. AD - University of Technology Sydney, Faculty of Science, School of Life Sciences, Sydney, NSW, Australia. FAU - Paudel, Keshav Raj AU - Paudel KR AD - Centre for Inflammation, Centenary Institute and University of Technology Sydney, Faculty of Science, School of Life Sciences, Sydney, NSW, Australia. FAU - Pickles, Sophie AU - Pickles S AD - Centre for Inflammation, Centenary Institute and University of Technology Sydney, Faculty of Science, School of Life Sciences, Sydney, NSW, Australia. FAU - Chimankar, Vrushali AU - Chimankar V AD - Centre for Inflammation, Centenary Institute and University of Technology Sydney, Faculty of Science, School of Life Sciences, Sydney, NSW, Australia. FAU - Kim, Richard Y AU - Kim RY AD - Immune Health, Hunter Medical Research Institute, University of Newcastle, Newcastle, NSW, Australia. AD - University of Technology Sydney, Faculty of Science, School of Life Sciences, Sydney, NSW, Australia. FAU - Horvart, Jay C AU - Horvart JC AD - Immune Health, Hunter Medical Research Institute, University of Newcastle, Newcastle, NSW, Australia. FAU - Dua, Kamal AU - Dua K AD - Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Sydney, NSW, Australia. FAU - Ieni, Antonio AU - Ieni A AD - Department of Human Pathology in Adult and Developmental Age "Gaetano Barresi", Section of Anatomic Pathology, University of Messina, Messina, Italy. FAU - Nucera, Francesco AU - Nucera F AD - Pneumologia, Dipartimento di Scienze Biomediche, Odontoiatriche e delle Immagini Morfologiche e Funzionali (BIOMORF), Universita degli Studi di Messina, Messina, Italy. FAU - Bielefeldt-Ohmann, Helle AU - Bielefeldt-Ohmann H AD - Australian Infectious Diseases Research Centre, School of Chemistry and Molecular Biosciences, University of Queensland, St. Lucia, QLD, Australia. FAU - Mazilli, Sarah AU - Mazilli S AD - Department of Medicine, Boston University School of Medicine, Boston, MA, United States. FAU - Caramori, Gaetano AU - Caramori G AD - Pneumologia, Dipartimento di Scienze Biomediche, Odontoiatriche e delle Immagini Morfologiche e Funzionali (BIOMORF), Universita degli Studi di Messina, Messina, Italy. FAU - Lyons, J Guy AU - Lyons JG AD - Department of Dermatology, The University of Sydney at Royal Prince Alfred Hospital, Sydney, Australia, and Centenary Institute, The University of Sydney, Sydney, NSW, Australia. FAU - Hansbro, Philip M AU - Hansbro PM AD - Immune Health, Hunter Medical Research Institute, University of Newcastle, Newcastle, NSW, Australia. AD - Centre for Inflammation, Centenary Institute and University of Technology Sydney, Faculty of Science, School of Life Sciences, Sydney, NSW, Australia. LA - eng PT - Journal Article PT - Review DEP - 20230925 PL - Switzerland TA - Front Oncol JT - Frontiers in oncology JID - 101568867 PMC - PMC10560855 OTO - NOTNLM OT - animal models OT - genetic and epigenetic alterations OT - lung cancer OT - risk factors OT - squamous cell carcinoma COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2023/10/11 06:45 MHDA- 2023/10/11 06:46 PMCR- 2023/01/01 CRDT- 2023/10/11 03:44 PHST- 2023/07/17 00:00 [received] PHST- 2023/08/29 00:00 [accepted] PHST- 2023/10/11 06:46 [medline] PHST- 2023/10/11 06:45 [pubmed] PHST- 2023/10/11 03:44 [entrez] PHST- 2023/01/01 00:00 [pmc-release] AID - 10.3389/fonc.2023.1260411 [doi] PST - epublish SO - Front Oncol. 2023 Sep 25;13:1260411. doi: 10.3389/fonc.2023.1260411. eCollection 2023.