PMID- 37819015
OWN - NLM
STAT- MEDLINE
DCOM- 20240129
LR  - 20240206
IS  - 1365-2230 (Electronic)
IS  - 0307-6938 (Linking)
VI  - 49
IP  - 2
DP  - 2024 Jan 25
TI  - Testing the feasibility of a co-designed intervention, comprising self-managed, 
      home-based, exercise training with embedded behavioural support and compression 
      therapy for people with venous leg ulcers receiving treatment at home (FISCU-II).
PG  - 135-142
LID - 10.1093/ced/llad342 [doi]
AB  - BACKGROUND: Venous leg ulcers (VLUs) heal slowly, are painful for patients and 
      are costly for healthcare systems; they also affect patients' quality of life. 
      Previous work suggests that supervised exercise training used in combination with 
      compression therapy may offer clinical benefits. However, a large population of 
      people with VLUs are unable to access such an intervention due to frailty and 
      age. OBJECTIVES: To assess the feasibility of 'FISCU Home' (a co-designed, 
      12-week home-based self-managed lifestyle programme based on exercise and 
      behaviour support) as an adjunct therapy to compression in people with VLUs. 
      METHODS: Forty people with VLUs, receiving treatment at home, were recruited from 
      community nursing and tissue viability teams, and via a newspaper advertisement. 
      Participants were randomized 1 : 1 either to exercise with behaviour support 
      (three times per week) plus compression therapy or compression only. The 
      feasibility of the programme was assessed using progression criteria that 
      included exercise attendance rate, loss to follow-up, patient preference(s) and 
      adverse events (AEs). Baseline assessments were repeated at 12 weeks and 
      6 months. Secondary outcomes (i.e. ulcer recurrence, healing rate and healing 
      time) were also documented at these intervals. Intervention and healthcare 
      utilization costs were calculated. RESULTS: The study recruitment rate was 65%, 
      while 75% of the exercise group participants attended all scheduled exercise 
      sessions. All participants completed compression therapy. No serious AEs or 
      exercise-related AEs were reported. Median (interquartile range) ulcer healing 
      time was shorter in the exercise group [29 (7-108) vs. 42 (6-116) weeks]. 
      CONCLUSIONS: The feasibility and acceptability of both a home- and exercise-based 
      lifestyle intervention in conjunction with compression therapy and the study 
      procedures are supported.
CI  - (c) The Author(s) 2023. Published by Oxford University Press on behalf of British 
      Association of Dermatologists.
FAU - Klonizakis, Markos
AU  - Klonizakis M
AUID- ORCID: 0000-0002-8864-4403
AD  - Lifestyle, Exercise and Nutrition Improvement (LENI) Research Group, Department 
      of Nursing and Midwifery, Sheffield Hallam University, Sheffield, UK.
FAU - Gumber, Anil
AU  - Gumber A
AD  - Lifestyle, Exercise and Nutrition Improvement (LENI) Research Group, Department 
      of Nursing and Midwifery, Sheffield Hallam University, Sheffield, UK.
FAU - McIntosh, Emma
AU  - McIntosh E
AD  - Lifestyle, Exercise and Nutrition Improvement (LENI) Research Group, Department 
      of Nursing and Midwifery, Sheffield Hallam University, Sheffield, UK.
AD  - Research and Innovation, Sheffield Health and Social Care NHS Foundation Trust, 
      Sheffield, UK.
FAU - Levesley, Maria
AU  - Levesley M
AD  - Integrated Care Team, Sheffield Teaching Hospitals NHS Foundation Trust, 
      Sheffield, UK.
FAU - Horspool, Michelle
AU  - Horspool M
AD  - Research and Innovation, Sheffield Health and Social Care NHS Foundation Trust, 
      Sheffield, UK.
FAU - Logan, Pip
AU  - Logan P
AD  - Centre for Rehabilitation and Ageing Research, University of Nottingham, 
      Nottingham, UK.
AD  - Nottingham CityCare Partnership, Nottingham, UK.
LA  - eng
GR  - DH_/Department of Health/United Kingdom
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - England
TA  - Clin Exp Dermatol
JT  - Clinical and experimental dermatology
JID - 7606847
SB  - IM
MH  - Humans
MH  - Compression Bandages
MH  - Ulcer
MH  - Quality of Life
MH  - Feasibility Studies
MH  - *Self-Management
MH  - Neoplasm Recurrence, Local
MH  - Exercise
MH  - *Varicose Ulcer/drug therapy
COIS- Conflicts of interest The authors declare no conflicts of interest.
EDAT- 2023/10/11 14:42
MHDA- 2024/01/29 06:44
CRDT- 2023/10/11 08:43
PHST- 2023/04/29 00:00 [received]
PHST- 2023/09/08 00:00 [revised]
PHST- 2023/10/01 00:00 [accepted]
PHST- 2024/01/29 06:44 [medline]
PHST- 2023/10/11 14:42 [pubmed]
PHST- 2023/10/11 08:43 [entrez]
AID - 7306654 [pii]
AID - 10.1093/ced/llad342 [doi]
PST - ppublish
SO  - Clin Exp Dermatol. 2024 Jan 25;49(2):135-142. doi: 10.1093/ced/llad342.