PMID- 37819475
OWN - NLM
STAT- MEDLINE
DCOM- 20240216
LR  - 20240216
IS  - 1432-5233 (Electronic)
IS  - 0940-5429 (Linking)
VI  - 61
IP  - 2
DP  - 2024 Feb
TI  - Associations between retinal microvascular flow, geometry, and progression of 
      diabetic retinopathy in type 2 diabetes: a 2-year longitudinal study.
PG  - 195-204
LID - 10.1007/s00592-023-02194-w [doi]
AB  - PURPOSE: To determine the association between retinal blood vessel flow and 
      geometric parameters and the risk of diabetic retinopathy (DR) progression 
      through a 2-year prospective cohort study. METHODS: Patients with type 2 diabetes 
      mellitus (T2DM) were recruited from a diabetic registry between November 2017 and 
      March 2019. All participants underwent standardized examinations at the baseline 
      and 2-year follow-up visit, and the presence and severity of DR were assessed 
      based on standard seven-field color fundus photographs. They also underwent 
      swept-source optical coherence tomography angiography (OCTA) imaging to obtain 
      measurements of foveal avascular zone area, blood vessel density (VD), fractal 
      dimension (FD), blood vessel tortuosity (BVT) in the superficial capillary plexus 
      (SCP) and deep capillary plexus (DCP). RESULTS: A total of 233 eyes of 125 
      patients were included, and 40 eyes (17.17%) experienced DR progression within 
      2 years. DR progression was significantly associated with lower baseline VD (odds 
      ratio [OR] 2.323 per SD decrease; 95% confidence interval [CI] 1.456-3.708; 
      P < 0.001), lower FD (OR, 2.484 per SD decrease; 95% CI 1.268-4.867; P = 0.008), 
      and higher BVT (OR, 2.076 per SD increase; 95% CI 1.382-3.121; P < 0.001) of the 
      DCP after adjusting for confounding factors. The addition of OCTA metrics 
      improved the predictive ability of the original model for DR progression (area 
      under the curve [AUC] from 0.725 to 0.805; P = 0.022). CONCLUSIONS: OCTA-derived 
      VD, FD and BVT in the DCP were independent predictors of DR progression and 
      showed additive value when added to established risk models predicting DR 
      progression.
CI  - (c) 2023. Springer-Verlag Italia S.r.l., part of Springer Nature.
FAU - Wu, Yi
AU  - Wu Y
AUID- ORCID: 0009-0000-0923-7248
AD  - State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen 
      University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual 
      Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, 
      Guangzhou, China.
FAU - He, Mingguang
AU  - He M
AD  - Research Centre for SHARP Vision, The Hong Kong Polytechnic University, Hong 
      Kong, China.
FAU - Huang, Wenyong
AU  - Huang W
AD  - State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen 
      University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual 
      Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, 
      Guangzhou, China.
FAU - Wang, Wei
AU  - Wang W
AD  - State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen 
      University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual 
      Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, 
      Guangzhou, China. wangwei@gzzoc.com.
LA  - eng
GR  - 82000901/National Natural Science Foundation of China/
GR  - 82171084/National Natural Science Foundation of China/
GR  - 81900866/National Natural Science Foundation of China/
GR  - 202102010162/Guangzhou Science & Technology Plan of Guangdong Pearl River Talents 
      Program/
GR  - 303060202400362/the Fundamental Research Funds of the State Key Laboratory of 
      Ophthalmology/
PT  - Journal Article
DEP - 20231011
PL  - Germany
TA  - Acta Diabetol
JT  - Acta diabetologica
JID - 9200299
SB  - IM
MH  - Humans
MH  - *Diabetic Retinopathy/etiology/complications
MH  - *Diabetes Mellitus, Type 2/complications
MH  - Longitudinal Studies
MH  - Fluorescein Angiography/methods
MH  - Prospective Studies
MH  - Retinal Vessels/diagnostic imaging
MH  - Tomography, Optical Coherence/methods
OTO - NOTNLM
OT  - Cohort
OT  - Diabetic retinopathy
OT  - Disease progression
OT  - Longitudinal
OT  - OCTA
EDAT- 2023/10/11 14:42
MHDA- 2024/02/16 06:42
CRDT- 2023/10/11 11:10
PHST- 2023/07/24 00:00 [received]
PHST- 2023/09/24 00:00 [accepted]
PHST- 2024/02/16 06:42 [medline]
PHST- 2023/10/11 14:42 [pubmed]
PHST- 2023/10/11 11:10 [entrez]
AID - 10.1007/s00592-023-02194-w [pii]
AID - 10.1007/s00592-023-02194-w [doi]
PST - ppublish
SO  - Acta Diabetol. 2024 Feb;61(2):195-204. doi: 10.1007/s00592-023-02194-w. Epub 2023 
      Oct 11.