PMID- 37820656
OWN - NLM
STAT- MEDLINE
DCOM- 20240205
LR  - 20240205
IS  - 1078-6791 (Print)
IS  - 1078-6791 (Linking)
VI  - 30
IP  - 1
DP  - 2024 Jan
TI  - Preliminary Study on the Evaluation of Skeletal Muscle Damage in Patients with 
      Diabetes Mellitus Using Ultrasonic Shear Wave Elastography.
PG  - 314-317
LID - AT9202 [pii]
AB  - OBJECTIVES: This study aimed to compare gastrocnemius muscle stiffness levels in 
      subjects with and without type 2 diabetes mellitus (T2DM) using shear wave 
      elastography (SWE). METHODS: This is a preliminary study enrolled patients with 
      T2DM and healthy subjects at the affiliated Hospital of Chengdu University of 
      Traditional Chinese Medicine between September 2021 and June 2022. Gastrocnemius 
      muscle stiffness was measured using SWE. RESULTS: A total of 120 individuals 
      (mean age: 52.09 +/- 5.40 years, 85 males) were enrolled, including 70 patients 
      with T2DM and 50 healthy subjects. There was no significant difference in E at 
      neutral ankle position, plantar flexion position and EBMI at neutral ankle 
      position between T2DM patients and healthy subjects (P > .05). E at upright 
      position (43.89 +/- 14.93 vs. 51.71 +/- 9.48, P = 0.001), EBMI at plantar flexion 
      position (1.17 (0.82-1.29) vs. 1.55 (1.21-1.84), P < .001) and upright position 
      (1.72 (1.23-2.16) vs. 2.10 (1.88-2.29), P < .001) of the T2DM patients were 
      significantly lower than those of healthy subjects. In T2DM patients, E at 
      upright position was negatively correlated with the disease course (r=-0.645, P < 
      .001), Hemoglobin A1c (HbA1c) concentration (r=-0.741, P < .001), and advanced 
      glycation end-product (AGEs) (r=-0.675, P < .001) but not with age ((r=-0.116, P 
      = .351). CONCLUSION: SWE results found that active muscle stiffness was 
      significantly lower in T2DM patients compared to healthy controls, suggesting 
      that evaluation of active muscle stiffness using SWE may be valuable in T2DM 
      patients to prevent gastrocnemius muscle damage.
FAU - Fang, Xue
AU  - Fang X
FAU - Han, Zhifen
AU  - Han Z
FAU - Kang, Yu
AU  - Kang Y
FAU - Sha, Xiaoxi
AU  - Sha X
FAU - Zhang, Yan
AU  - Zhang Y
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Altern Ther Health Med
JT  - Alternative therapies in health and medicine
JID - 9502013
SB  - IM
MH  - Male
MH  - Humans
MH  - Middle Aged
MH  - *Elasticity Imaging Techniques/methods
MH  - Ultrasonics
MH  - *Diabetes Mellitus, Type 2/complications/diagnostic imaging
MH  - Muscle, Skeletal/diagnostic imaging/physiology
MH  - Healthy Volunteers
EDAT- 2023/10/12 00:43
MHDA- 2024/02/05 06:43
CRDT- 2023/10/11 18:43
PHST- 2024/02/05 06:43 [medline]
PHST- 2023/10/12 00:43 [pubmed]
PHST- 2023/10/11 18:43 [entrez]
AID - AT9202 [pii]
PST - ppublish
SO  - Altern Ther Health Med. 2024 Jan;30(1):314-317.