PMID- 37820979
OWN - NLM
STAT- Publisher
LR  - 20240430
IS  - 1873-5894 (Electronic)
IS  - 0730-725X (Linking)
VI  - 104
DP  - 2023 Oct 17
TI  - Transient susceptibility imaging as a measure of hemodynamic compromise: A pilot 
      study.
PG  - 105-114
LID - S0730-725X(23)00169-8 [pii]
LID - 10.1016/j.mri.2023.10.004 [doi]
AB  - BACKGROUND AND PURPOSE: The purpose of this study was to test the hypothesis that 
      hemodynamically compromised brains exhibit transient changes in magnetic 
      susceptibility throughout the cardiac cycle, and to model these changes using 
      Linear System Theory to extract an index that reflects cerebrovascular reserve. 
      MATERIALS AND METHODS: Eleven patients with angiographically-confirmed 
      intracranial atherosclerotic disease with >50% stenosis were imaged with 
      susceptibility weighted, cardiac-gated single shot images of cerebral Oxygen 
      Extraction Fraction (OEF) at different timepoints of the cardiac cycle. Cardiac 
      gating of the OEF acquisition allowed interrogation of oxygenated blood and the 
      detection of changes throughout the cardiac cycle. Independent component analysis 
      (ICA) of raw k-space data across the cardiac phase allowed MRI signal 
      decomposition into dynamic and static components for image reconstruction. An 
      asymmetry index score of the resultant parametric images were compared to test 
      the hypothesis that variation in hemoglobin-induced susceptibility across the 
      cardiac cycle indeed reflects pathophysiology of cerebrovascular disease. A 
      mathematical model was derived to parameterize physiologic changes induced by the 
      presence of a hemodynamically significant stenosis in the brain as a tissue 
      impulse response parameter (beta). RESULTS: OEF was elevated in the affected 
      hemisphere (50.34 +/- 12.13% vs 46.93 +/- 12.34%), but failed to reach statistical 
      significance (p < .0796). Transient changes in the OEF signal showed significant 
      distinction between healthy and compromised tissue (0.56 +/- 0.067 vs 0.44 +/- 0.067, 
      p < .019)). The derived tissue impulse response function was found to be 
      significant as well (10.72 +/- 3.48 10(-3) ms(-1), 9.69 +/- 3.51 10(-3) ms(-1); 
      p < .037). CONCLUSION: In this pilot study, we found transient OEF and beta to be 
      significant predictors of hemispheric compromise.
CI  - Copyright (c) 2023 Elsevier Inc. All rights reserved.
FAU - Cantrell, Charles G
AU  - Cantrell CG
AD  - University of Chicago, Department of Radiology, Billings Hospital, P220 5841 
      South Maryland Avenue, MC2026, Chicago, IL 60637, USA.
FAU - Nguyen, Vivian
AU  - Nguyen V
AD  - University of Chicago, Department of Radiology, Billings Hospital, P220 5841 
      South Maryland Avenue, MC2026, Chicago, IL 60637, USA; Illinois Institute of 
      Technology, Department of Biomedical Engineering, Wishnick Hall 3255 South 
      Dearborn Street, Suite 314, Chicago, IL 60616, USA.
FAU - Vakil, Parmede
AU  - Vakil P
AD  - University of Illinois, College of Medicine, 1853 W Polk St, Chicago, IL 60612, 
      USA; Northwestern University, Department of Radiology, 676 N. St. Clair St. Suite 
      800, Chicago, IL 60611, USA.
FAU - Jeong, Yong
AU  - Jeong Y
AD  - McCormick School of Engineering, Northwestern University, Technological 
      Institute, 2145 Sheridan Road, E310, Evanston, IL 60208, USA.
FAU - Menon, Rajiv
AU  - Menon R
AD  - New York University, Langone Medical Center, 424 E 34th St., New York, NY 10016, 
      USA.
FAU - Ansari, Sameer Ahmad
AU  - Ansari SA
AD  - Northwestern University, Department of Radiology, 676 N. St. Clair St. Suite 800, 
      Chicago, IL 60611, USA; Northwestern University, Departments of Neurology and 
      Neurological Surgery, 676 North St. Clair Street Suite 2210, Chicago, IL 60611, 
      USA.
FAU - Kawaji, Keigo
AU  - Kawaji K
AD  - University of Chicago, Department of Radiology, Billings Hospital, P220 5841 
      South Maryland Avenue, MC2026, Chicago, IL 60637, USA; Illinois Institute of 
      Technology, Department of Biomedical Engineering, Wishnick Hall 3255 South 
      Dearborn Street, Suite 314, Chicago, IL 60616, USA.
FAU - Carroll, Timothy J
AU  - Carroll TJ
AD  - University of Chicago, Department of Radiology, Billings Hospital, P220 5841 
      South Maryland Avenue, MC2026, Chicago, IL 60637, USA. Electronic address: 
      tjcarroll@uchicago.edu.
LA  - eng
PT  - Journal Article
DEP - 20231017
PL  - Netherlands
TA  - Magn Reson Imaging
JT  - Magnetic resonance imaging
JID - 8214883
SB  - IM
OTO - NOTNLM
OT  - Cardiac gated OEF
OT  - Intracranial atherosclerotic disease (ICAD)
OT  - Stroke imaging
OT  - Susceptibility imaging
OT  - Transient susceptibility imaging
COIS- Declaration of Competing Interest The authors declare no conflict of interest.
EDAT- 2023/10/12 00:43
MHDA- 2023/10/12 00:43
CRDT- 2023/10/11 19:39
PHST- 2023/04/10 00:00 [received]
PHST- 2023/08/11 00:00 [revised]
PHST- 2023/10/07 00:00 [accepted]
PHST- 2023/10/12 00:43 [pubmed]
PHST- 2023/10/12 00:43 [medline]
PHST- 2023/10/11 19:39 [entrez]
AID - S0730-725X(23)00169-8 [pii]
AID - 10.1016/j.mri.2023.10.004 [doi]
PST - aheadofprint
SO  - Magn Reson Imaging. 2023 Oct 17;104:105-114. doi: 10.1016/j.mri.2023.10.004.