PMID- 37821063 OWN - NLM STAT- MEDLINE DCOM- 20231127 LR - 20231127 IS - 1096-0953 (Electronic) IS - 0013-9351 (Linking) VI - 239 IP - Pt 1 DP - 2023 Dec 15 TI - A co-twin control study of in utero exposure to poly- and perfluoroalkyl substances and associations with neonatal thyroid-stimulating hormone. PG - 117350 LID - S0013-9351(23)02154-0 [pii] LID - 10.1016/j.envres.2023.117350 [doi] AB - Research quantifying associations between early-life exposure to poly- and perfluoroalkyl substances (PFAS) and neonatal thyroid hormone levels is limited and reports inconsistent results. This study aimed to examine the associations of in utero PFAS exposure with neonatal thyroid-stimulating hormone (TSH), and to verify whether genetic and familial factors contribute to these associations. Within Wuhan Twin Birth Cohort study, we included 148 mother-twin pairs recruited between March 2016 and January 2018. Maternal plasma PFAS concentrations were measured at three different trimesters and averaged. Additionally, we measured cord plasma PFAS concentrations for twin newborns and retrieved their TSH levels from the medical system. Multivariable linear regression, generalized estimation equation, and linear mixed models were used to examine the covariate-adjusted associations. For maternal PFAS analyses, a 2-fold increment of average maternal perfluorooctanoic acid (PFOA) and perfluorodecanoic acid (PFDA) concentrations was linked with a 15% (95% CI: 2.5%, 28%) and 14% (95% CI: 2.4%, 28%) increase in neonatal TSH, respectively. For twin newborns discordant for PFAS exposure, a 2-fold increment of cord plasma PFOA, PFDA, perfluoroundecanoic acid (PFUdA), and perfluorohexanesulfonic acid (PFHxS) concentrations was related to a 7.1% (95% CI: 0.31%, 14%), 12% (95% CI: 4.8%, 20%), 7.5% (95% CI: 0.30%, 15%), and 8.5% (95% CI: 3.0%, 14%) increase in TSH among twins as individuals, respectively. Although these associations were mainly observed between twin pairs, certain PFAS exposure might have an independent association with increased TSH. Our present study suggests that higher maternal and cord plasma PFAS concentrations are associated with increased neonatal TSH, and genetic and familial factors contribute to these associations. CI - Copyright (c) 2023 Elsevier Inc. All rights reserved. FAU - Hu, Liqin AU - Hu L AD - Institute of Maternal and Child Health, Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China. FAU - Mei, Hong AU - Mei H AD - Institute of Maternal and Child Health, Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China. FAU - Cai, Xiaonan AU - Cai X AD - Institute of Maternal and Child Health, Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China. FAU - Xiang, Feiyan AU - Xiang F AD - Institute of Maternal and Child Health, Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China. FAU - Li, Na AU - Li N AD - Maternal Health Care Department, Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China. FAU - Huang, Zhen AU - Huang Z AD - Department of Pathology, Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China. FAU - Duan, Zhengrong AU - Duan Z AD - Maternal Health Care Department, Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China. FAU - Yang, Pan AU - Yang P AD - Department of Public Health and Preventive Medicine, School of Medicine, Jinan University, Guangzhou, 510632, Guangdong, PR China; Guangdong Key Laboratory of Environmental Pollution and Health, Jinan University, Guangzhou, 510632, Guangdong, PR China. FAU - Xiao, Han AU - Xiao H AD - Institute of Maternal and Child Health, Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China. Electronic address: tjxiaohan1980@163.com. LA - eng PT - Journal Article DEP - 20231011 PL - Netherlands TA - Environ Res JT - Environmental research JID - 0147621 RN - 9002-71-5 (Thyrotropin) RN - 0 (Thyroid Hormones) RN - 947VD76D3L (perfluorooctanoic acid) RN - 335-76-2 (perfluorodecanoic acid) RN - 0 (Fluorocarbons) RN - 0 (Environmental Pollutants) RN - 0 (Alkanesulfonic Acids) SB - IM MH - Female MH - Humans MH - Infant, Newborn MH - Thyrotropin MH - Cohort Studies MH - Thyroid Hormones MH - *Fluorocarbons/toxicity MH - Mothers MH - *Environmental Pollutants MH - *Alkanesulfonic Acids OTO - NOTNLM OT - Cord blood OT - Poly- and perfluoroalkyl substances OT - Pregnancy OT - Thyroid-stimulating hormone OT - Twins COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2023/10/12 00:43 MHDA- 2023/11/27 12:43 CRDT- 2023/10/11 19:42 PHST- 2023/05/31 00:00 [received] PHST- 2023/10/06 00:00 [revised] PHST- 2023/10/07 00:00 [accepted] PHST- 2023/11/27 12:43 [medline] PHST- 2023/10/12 00:43 [pubmed] PHST- 2023/10/11 19:42 [entrez] AID - S0013-9351(23)02154-0 [pii] AID - 10.1016/j.envres.2023.117350 [doi] PST - ppublish SO - Environ Res. 2023 Dec 15;239(Pt 1):117350. doi: 10.1016/j.envres.2023.117350. Epub 2023 Oct 11.