PMID- 37822294
OWN - NLM
STAT- MEDLINE
DCOM- 20231216
LR  - 20240221
IS  - 2328-9503 (Electronic)
IS  - 2328-9503 (Linking)
VI  - 10
IP  - 12
DP  - 2023 Dec
TI  - Structural and functional connectivity alteration patterns of the cingulate gyrus 
      in Type 2 diabetes.
PG  - 2305-2315
LID - 10.1002/acn3.51918 [doi]
AB  - OBJECTIVE: We aimed to reveal the role of structural and functional alterations 
      of cingulate gyrus in early cognitive impairment in Type 2 diabetes mellitus 
      (T2DM) patients. METHODS: Fifty-six T2DM patients and 60 healthy controls (HCs) 
      underwent a neuropsychological assessment and sagittal three-dimensional 
      T1-weighted and resting-state functional MRI. Differences in the cortical 
      thickness of the cingulate cortex and the functional connectivity (FC) of the 
      nine subregions of the cingulate gyrus and the whole brain were compared between 
      T2DM patients and HCs. Correlation analysis was performed between cortex 
      thickness and FC and the participants' clinical/cognitive variables. RESULTS: The 
      cortical thickness of the cingulate gyrus was not significantly different between 
      T2DM patients and HCs. However, the T2DM patients showed significantly lower FC 
      between the pregenual ACC (pACC) and the bilateral hippocampus, significantly 
      higher FC between the pACC and bilateral lateral prefrontal cortex (LPFC) and 
      left precentral gyrus, and significantly lower FC between the retrosplenial 
      cortex (RSC) and right cerebellar Crus I. The FC between the pACC and the left 
      hippocampus was negatively correlated with the FC between the pACC and LPFC 
      (r = -0.306, p = 0.022). INTERPRETATION: The pACC and the RSC show dysfunctional 
      connectivity before the appearance of structural abnormalities in T2DM patients. 
      Abnormal FC of the pACC with the bilateral hippocampus and LPFC may imply a 
      neural compensatory mechanism for memory function. These findings provide 
      valuable information and new directions for possible interventions for the 
      T2DM-related cognitive impairment.
CI  - (c) 2023 The Authors. Annals of Clinical and Translational Neurology published by 
      Wiley Periodicals LLC on behalf of American Neurological Association.
FAU - Zhang, Dongsheng
AU  - Zhang D
AUID- ORCID: 0000-0001-9633-8521
AD  - Department of MRI, Shaanxi Provincial People's Hospital, Xi'an, 710068, China.
FAU - Huang, Yang
AU  - Huang Y
AD  - Department of MRI, Shaanxi Provincial People's Hospital, Xi'an, 710068, China.
FAU - Liu, Shasha
AU  - Liu S
AD  - Department of MRI, Shaanxi Provincial People's Hospital, Xi'an, 710068, China.
FAU - Gao, Jie
AU  - Gao J
AD  - Department of MRI, Shaanxi Provincial People's Hospital, Xi'an, 710068, China.
FAU - Liu, Weirui
AU  - Liu W
AD  - Department of MRI, Shaanxi Provincial People's Hospital, Xi'an, 710068, China.
FAU - Liu, Wanting
AU  - Liu W
AD  - Department of MRI, Shaanxi Provincial People's Hospital, Xi'an, 710068, China.
FAU - Ai, Kai
AU  - Ai K
AD  - Department of Clinical Science, Philips Healthcare, Xi'an, 710000, China.
FAU - Lei, Xiaoyan
AU  - Lei X
AD  - Department of MRI, Shaanxi Provincial People's Hospital, Xi'an, 710068, China.
FAU - Zhang, Xiaoling
AU  - Zhang X
AD  - Department of MRI, Shaanxi Provincial People's Hospital, Xi'an, 710068, China.
LA  - eng
GR  - 82170820/National Natural Science Foundation of China/
GR  - 2018ZDXM-SF-038/Research and Development Program of Shaanxi Province of China/
GR  - 2023-YBSF-606/Social Development Science and Technology Research Project of 
      Shaanxi Province of China/
GR  - 2020YXM-04/Shaanxi Provincial People's Hospital Technological Development 
      Incubation Foundation of China/
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20231012
PL  - United States
TA  - Ann Clin Transl Neurol
JT  - Annals of clinical and translational neurology
JID - 101623278
SB  - IM
MH  - Humans
MH  - *Gyrus Cinguli/diagnostic imaging
MH  - *Diabetes Mellitus, Type 2/complications
MH  - Magnetic Resonance Imaging/methods
MH  - Brain
MH  - Prefrontal Cortex/diagnostic imaging
MH  - Agenesis of Corpus Callosum
PMC - PMC10723245
COIS- The authors report no competing interests.
EDAT- 2023/10/12 06:43
MHDA- 2023/12/17 09:42
PMCR- 2023/10/12
CRDT- 2023/10/12 03:57
PHST- 2023/08/22 00:00 [revised]
PHST- 2023/05/26 00:00 [received]
PHST- 2023/09/08 00:00 [accepted]
PHST- 2023/12/17 09:42 [medline]
PHST- 2023/10/12 06:43 [pubmed]
PHST- 2023/10/12 03:57 [entrez]
PHST- 2023/10/12 00:00 [pmc-release]
AID - ACN351918 [pii]
AID - 10.1002/acn3.51918 [doi]
PST - ppublish
SO  - Ann Clin Transl Neurol. 2023 Dec;10(12):2305-2315. doi: 10.1002/acn3.51918. Epub 
      2023 Oct 12.