PMID- 37822441
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231031
IS  - 2168-8184 (Print)
IS  - 2168-8184 (Electronic)
IS  - 2168-8184 (Linking)
VI  - 15
IP  - 9
DP  - 2023 Sep
TI  - Hypereosinophilic Syndrome Endocarditis With Severe Biventricular Failure 
      Complicated by Sepsis: A Challenging Case.
PG  - e44963
LID - 10.7759/cureus.44963 [doi]
LID - e44963
AB  - Hypereosinophilic syndrome (HES) is a myeloproliferative disorder characterized 
      by persistent hypereosinophilia that is associated with multi-organ damage. 
      Eosinophilic endocarditis is a serious complication of HES. The exact prevalence 
      of the disease is unknown, and it is characterized by a persistently elevated 
      eosinophil count, resulting in multi-organ involvement due to eosinophilic 
      infiltration. We present a case of a 65-year-old Caucasian male patient who 
      presented with one-week symptoms of feeling unwell and intermittent pleuritic 
      chest pain. His medical history was significant for the idiopathic 
      hypereosinophilic syndrome, eosinophilic myocarditis, hypertension (HTN), type 2 
      diabetes mellitus (T2DM), and chronic obstructive pulmonary disease (COPD). 
      Inflammatory markers were raised, including eosinophil count, and a transthoracic 
      echocardiogram (TTE) showed a mass attached to the mitral valve (MV) leaflets, 
      suggesting vegetation or thrombus. The patient was commenced on intravenous 
      antibiotics, inotropes for septic shock, and low molecular weight heparin (LMWH) 
      for a possible thrombus. He showed mild biochemical improvement initially without 
      any clinical improvement before further deterioration secondary to aspiration 
      pneumonia. He was seen by the palliative care team and mental health team for 
      confusion and agitation and was put on the palliative care pathway. All active 
      medical treatment was stopped, and the patient succumbed to his illness three 
      weeks into his admission.
CI  - Copyright (c) 2023, Khan et al.
FAU - Khan, Zahid
AU  - Khan Z
AD  - Acute Medicine, Mid and South Essex NHS Foundation Trust, Southend-on-Sea, GBR.
AD  - Cardiology, Barts Heart Centre, London, GBR.
AD  - Cardiology and General Medicine, Barking, Havering and Redbridge University 
      Hospitals NHS Trust, London, GBR.
AD  - Cardiology, Royal Free Hospital, London, GBR.
FAU - Pabani, Umesh Kumar
AU  - Pabani UK
AD  - Internal Medicine, Mid and South Essex NHS Foundation Trust, Southend-on-Sea, 
      GBR.
LA  - eng
PT  - Case Reports
DEP - 20230909
PL  - United States
TA  - Cureus
JT  - Cureus
JID - 101596737
PMC - PMC10564259
OTO - NOTNLM
OT  - copd (chronic obstructive pulmonary disease)
OT  - eosinophilic endocarditis
OT  - eosinophilic myocarditis
OT  - hypereosinophilic syndromes
OT  - idiopathic hypereosinophilic syndrome
OT  - inotropes
OT  - loeffler endocarditis
OT  - nosocomial aspiration pneumonia
OT  - prednisolone and eosinophilia
OT  - septic shock in endocarditis
COIS- The authors have declared that no competing interests exist.
EDAT- 2023/10/12 06:43
MHDA- 2023/10/12 06:44
PMCR- 2023/09/09
CRDT- 2023/10/12 04:02
PHST- 2023/09/09 00:00 [accepted]
PHST- 2023/10/12 06:44 [medline]
PHST- 2023/10/12 06:43 [pubmed]
PHST- 2023/10/12 04:02 [entrez]
PHST- 2023/09/09 00:00 [pmc-release]
AID - 10.7759/cureus.44963 [doi]
PST - epublish
SO  - Cureus. 2023 Sep 9;15(9):e44963. doi: 10.7759/cureus.44963. eCollection 2023 Sep.