PMID- 37823572
OWN - NLM
STAT- MEDLINE
DCOM- 20231102
LR  - 20231221
IS  - 1336-0329 (Electronic)
IS  - 1210-0668 (Linking)
VI  - 57
IP  - 1
DP  - 2023 Jan 1
TI  - Oxidative stress in liver of streptozotocin-induced diabetic mice fed a high-fat 
      diet: A treatment role of Artemisia annua L.
PG  - 242-251
LID - 10.2478/enr-2023-0027 [doi]
AB  - Objective. The aim of this study was the investigation of a treatment role of 
      Artemisia annua L. (AA) on liver dysfunction and oxidative stress in high-fat 
      diet/streptozotocin-induced diabetic (HFD/STZ) mice. Methods. Sixty mice were 
      divided into 12 groups including control, untreated diabetic, and treated 
      diabetic ones with metformin (250 mg/kg), and doses of 100, 200, and 400 mg/kg of 
      water (hot and cold) and alcoholic (methanol) extracts of AA. Type 2 diabetes 
      mellitus (T2DM) was induced in mice by high-fat diet for 8 weeks and STZ 
      injection in experimental animals. After treatment with doses of 100, 200 or 400 
      mg/kg of AA extracts in HFD/STZ diabetic mice for 4 weeks, oxidative stress 
      markers such as malondialdehyde (MDA), glutathione (GSH), and free radicals (ROS) 
      were determined in the liver tissue in all groups. Results. Diabetic mice treated 
      with metformin and AA extracts showed a significant decrease in ROS and MDA 
      concentrations and a notable increase in GSH level in the liver. Effectiveness of 
      higher doses of AA extracts (200 and 400 mg/kg), especially in hot-water and 
      alcoholic ones, were similar to and/or even more effective than metformin. 
      Conclusion. Therapeutic effects of AA on liver dysfunction showed that 
      antioxidant activity of hot-water and alcoholic AA extracts were similar or 
      higher than of metformin.
CI  - (c) 2023 Mahshid Ghanbari et al., published by Sciendo.
FAU - Ghanbari, Mahshid
AU  - Ghanbari M
AD  - 1Department of Toxicology and Pharmacology, Faculty of Pharmacy, Mazandaran 
      University of Medical Sciences, Sari, Iran.
FAU - Shokrzadeh Lamuki, Mohammad
AU  - Shokrzadeh Lamuki M
AD  - 1Department of Toxicology and Pharmacology, Faculty of Pharmacy, Mazandaran 
      University of Medical Sciences, Sari, Iran.
AD  - 2Pharmaceutical Science Research Center, Hemoglobinopathy Institute, Mazandaran 
      University of Medical Sciences, Sari, Iran.
FAU - Sadeghimahalli, Forouzan
AU  - Sadeghimahalli F
AD  - 2Pharmaceutical Science Research Center, Hemoglobinopathy Institute, Mazandaran 
      University of Medical Sciences, Sari, Iran.
AD  - 3Department of Physiology, School of Medicine, Mazandaran University of Medical 
      Sciences, Sari, Iran.
FAU - Habibi, Emran
AU  - Habibi E
AD  - 2Pharmaceutical Science Research Center, Hemoglobinopathy Institute, Mazandaran 
      University of Medical Sciences, Sari, Iran.
AD  - 4Department of Pharmacognosy, Faculty of Pharmacy, Mazandaran University of 
      Medical Sciences, Sari, Iran.
FAU - Sayedi Moqadam, Mohammad Reza
AU  - Sayedi Moqadam MR
AD  - 1Department of Toxicology and Pharmacology, Faculty of Pharmacy, Mazandaran 
      University of Medical Sciences, Sari, Iran.
LA  - eng
PT  - Journal Article
DEP - 20231012
PL  - Germany
TA  - Endocr Regul
JT  - Endocrine regulations
JID - 9112018
RN  - 5W494URQ81 (Streptozocin)
RN  - 0 (Reactive Oxygen Species)
RN  - 9100L32L2N (Metformin)
RN  - GAN16C9B8O (Glutathione)
RN  - 059QF0KO0R (Water)
RN  - 0 (Plant Extracts)
RN  - 0 (Blood Glucose)
SB  - IM
MH  - Mice
MH  - Animals
MH  - *Diabetes Mellitus, Type 2/chemically induced/drug therapy
MH  - *Artemisia annua/metabolism
MH  - Streptozocin/pharmacology/therapeutic use
MH  - *Diabetes Mellitus, Experimental/chemically induced/drug therapy
MH  - Reactive Oxygen Species/pharmacology/therapeutic use
MH  - Diet, High-Fat/adverse effects
MH  - Oxidative Stress
MH  - *Metformin/pharmacology
MH  - Glutathione/metabolism
MH  - *Liver Diseases/drug therapy
MH  - Water
MH  - Plant Extracts/pharmacology
MH  - Blood Glucose
OTO - NOTNLM
OT  - Artemisia annua L.
OT  - metformin
OT  - oxidative stress markers
OT  - type 2 diabetes
EDAT- 2023/10/12 12:43
MHDA- 2023/11/02 12:45
CRDT- 2023/10/12 08:03
PHST- 2023/11/02 12:45 [medline]
PHST- 2023/10/12 12:43 [pubmed]
PHST- 2023/10/12 08:03 [entrez]
AID - enr-2023-0027 [pii]
AID - 10.2478/enr-2023-0027 [doi]
PST - epublish
SO  - Endocr Regul. 2023 Oct 12;57(1):242-251. doi: 10.2478/enr-2023-0027. Print 2023 
      Jan 1.