PMID- 37824397
OWN - NLM
STAT- Publisher
LR  - 20231121
IS  - 1473-5857 (Electronic)
IS  - 0268-1315 (Linking)
DP  - 2023 Oct 21
TI  - Type 2 diabetes mellitus is associated with manic morbidity in elderly patients 
      with mood disorders.
LID - 10.1097/YIC.0000000000000515 [doi]
AB  - The association between mood disorders, especially bipolar disorder (BD), and 
      metabolic disorders, is long known. However, to which extent metabolic disorders 
      affect the course of mood disorders in late life is still open to inquiring. To 
      assess the impact of type 2 diabetes mellitus (T2DM) on late-life mood disorders 
      a retrospective chart review was performed. Elderly depressive patients (>/= 65 
      years) diagnosed with Major Depressive Disorder (N = 57) or BD (N = 43) and 
      followed up for at least 18 months were included and subdivided according to the 
      presence of T2DM comorbidity. Vascular encephalopathy (39.1% vs. 15.6%, P 
       = 0.021) and neurocognitive disorders (21.7% vs. 5.2%, P  = 0.028), were more 
      frequently reported in patients with T2DM than in those without. Patients with 
      T2DM showed a greater percentage of follow-up time in manic episodes (r = -0.23, 
      P  = 0.020) and a higher rate of manic episode(s) during follow-up (21.7% vs. 
      5.2%, P  = 0.028) than those without. When restricting longitudinal analyses to 
      patients with bipolar spectrum disorders, results were confirmed. In line with 
      the well-known connection between BD and metabolic disorders, our data support an 
      association between T2DM and unfavorable course of illness in the elderly with 
      BD.
CI  - Copyright (c) 2023 The Author(s). Published by Wolters Kluwer Health, Inc.
FAU - Weiss, Francesco
AU  - Weiss F
AD  - Department of Clinical and Experimental Medicine, University of Pisa, Pisa.
FAU - Brancati, Giulio Emilio
AU  - Brancati GE
AD  - Department of Clinical and Experimental Medicine, University of Pisa, Pisa.
FAU - Elefante, Camilla
AU  - Elefante C
AD  - Department of Clinical and Experimental Medicine, University of Pisa, Pisa.
FAU - Petrucci, Alessandra
AU  - Petrucci A
AD  - Department of Psychiatry, Local Health Unit n. 2, Terni.
FAU - Gemmellaro, Teresa
AU  - Gemmellaro T
AD  - Department of Psychiatry, North-Western Tuscany Region, NHS, Local Health Unit, 
      Cecina-LI.
FAU - Lattanzi, Lorenzo
AU  - Lattanzi L
AD  - Azienda Ospedaliero-Universitaria Pisana.
FAU - Perugi, Giulio
AU  - Perugi G
AD  - Department of Clinical and Experimental Medicine, University of Pisa, Pisa.
AD  - Institute of Behavioral Science 'G. De Lisio', Pisa, Italy.
LA  - eng
PT  - Journal Article
DEP - 20231021
PL  - England
TA  - Int Clin Psychopharmacol
JT  - International clinical psychopharmacology
JID - 8609061
SB  - IM
EDAT- 2023/10/12 18:43
MHDA- 2023/10/12 18:43
CRDT- 2023/10/12 12:53
PHST- 2023/10/12 18:43 [pubmed]
PHST- 2023/10/12 18:43 [medline]
PHST- 2023/10/12 12:53 [entrez]
AID - 00004850-990000000-00101 [pii]
AID - 10.1097/YIC.0000000000000515 [doi]
PST - aheadofprint
SO  - Int Clin Psychopharmacol. 2023 Oct 21. doi: 10.1097/YIC.0000000000000515.