PMID- 37827353 OWN - NLM STAT- MEDLINE DCOM- 20231120 LR - 20231120 IS - 1873-6424 (Electronic) IS - 0269-7491 (Linking) VI - 339 DP - 2023 Dec 15 TI - Non-invasive biomonitoring of infant exposure to environmental organic pollutants in north-western Spain based on hair analysis. Identification of potential sources. PG - 122705 LID - S0269-7491(23)01707-4 [pii] LID - 10.1016/j.envpol.2023.122705 [doi] AB - Recent years have seen growing interest in hair sample analysis to detect organic pollutants (OPs). This biological matrix can be analysed non-invasively for biomonitoring of OPs over a wide exposure window. Obtaining hair sample amounts that meet the needs of the analytical methodology required for the determination of the POs of interest can be challenging, especially in infants. As a result, studies assessing organic pollutants in infant hair have been very scarce. We quantified levels of about 60 OPs, including persistent organic pollutants (POPs), in 110 hair samples from a patient cohort (60 mothers and 50 infants) from Santiago de Compostela (north-western Spain). For each participant we examined relationship between OP levels and corresponding epidemiological parameters using correlations, principal component analysis (PCA), hierarchical cluster analysis, and Multivariate analysis of variance (MANOVA). For many OPs we observed significant correlations with place of residence, parity, and maternal age, as well as pet ownership. Evaluation of dietary habits showed significant associations between levels some OPs and the consumption of fish, molluscs, and cereal. There were significant associations between chlorpyrifos and deltamethrin levels and infant birth characteristics such as birthweight and head circumference. Relations between OP levels in the hair of mothers and their infants were also examined, revealing common sources of exposure for dioxin-like polychlorinated biphenyls (DLPCBs), non-dioxin-like polychlorinated biphenyls (NDLPCBs), polybrominated diphenyl ethers (PBDEs), and polycyclic aromatic hydrocarbons (PAHs). Levels of fluoranthene (F), pyrene (P), endrin, and some PBDEs in maternal hair were significantly correlated with those in infant hair. Our findings identified common sources of exposure to OPs of distinct chemical classes. CI - Copyright (c) 2023 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - Sanguos, Carolina Lopez AU - Sanguos CL AD - Department of Neonatology, University Clinical Hospital of Santiago de Compostela, Santiago de Compostela, 15704, Spain; IDIS-Health Research Institute of Santiago de Compostela, Santiago de Compostela, 15704, Spain; Faculty of Medicine, University of Santiago de Compostela, Santiago de Compostela, 15704, Spain; Primary Care Interventions to Prevent Maternal and Child Chronic Diseases of Perinatal and Developmental Origin (RICORS), Instituto de Salud Carlos III, Madrid, Spain. Electronic address: Carolina.lopez.sanguos@sergas.es. FAU - Garcia, Laura Gallego AU - Garcia LG AD - IDIS-Health Research Institute of Santiago de Compostela, Santiago de Compostela, 15704, Spain; Primary Care Interventions to Prevent Maternal and Child Chronic Diseases of Perinatal and Developmental Origin (RICORS), Instituto de Salud Carlos III, Madrid, Spain. Electronic address: Laura.Gallego.Garcia@sergas.es. FAU - Suarez, Olalla Lopez AU - Suarez OL AD - Department of Neonatology, University Clinical Hospital of Santiago de Compostela, Santiago de Compostela, 15704, Spain; IDIS-Health Research Institute of Santiago de Compostela, Santiago de Compostela, 15704, Spain; Faculty of Medicine, University of Santiago de Compostela, Santiago de Compostela, 15704, Spain; Primary Care Interventions to Prevent Maternal and Child Chronic Diseases of Perinatal and Developmental Origin (RICORS), Instituto de Salud Carlos III, Madrid, Spain. Electronic address: Olalla.Elena.Lopez.Suarez@sergas.es. FAU - Picans-Leis, Rosaura AU - Picans-Leis R AD - Department of Neonatology, University Clinical Hospital of Santiago de Compostela, Santiago de Compostela, 15704, Spain; IDIS-Health Research Institute of Santiago de Compostela, Santiago de Compostela, 15704, Spain; Faculty of Medicine, University of Santiago de Compostela, Santiago de Compostela, 15704, Spain; Primary Care Interventions to Prevent Maternal and Child Chronic Diseases of Perinatal and Developmental Origin (RICORS), Instituto de Salud Carlos III, Madrid, Spain. Electronic address: rosaura.picans@rai.usc.es. FAU - Martinez-Carballo, Elena AU - Martinez-Carballo E AD - Primary Care Interventions to Prevent Maternal and Child Chronic Diseases of Perinatal and Developmental Origin (RICORS), Instituto de Salud Carlos III, Madrid, Spain; Food and Health Omics, Department of Analytical and Food Chemistry, Faculty of Sciences, Campus da Auga, University of Vigo, Ourense, 32004, Spain; Instituto de Agroecoloxia e Alimentacion (IAA), Campus Auga, Universidade de Vigo, Ourense, 32004, Spain. Electronic address: elena.martinez@uvigo.gal. FAU - Couce, Maria Luz AU - Couce ML AD - Department of Neonatology, University Clinical Hospital of Santiago de Compostela, Santiago de Compostela, 15704, Spain; IDIS-Health Research Institute of Santiago de Compostela, Santiago de Compostela, 15704, Spain; Faculty of Medicine, University of Santiago de Compostela, Santiago de Compostela, 15704, Spain; Primary Care Interventions to Prevent Maternal and Child Chronic Diseases of Perinatal and Developmental Origin (RICORS), Instituto de Salud Carlos III, Madrid, Spain. Electronic address: Maria.Luz.Couce.Pico@sergas.es. LA - eng PT - Journal Article DEP - 20231010 PL - England TA - Environ Pollut JT - Environmental pollution (Barking, Essex : 1987) JID - 8804476 RN - 0 (Environmental Pollutants) RN - DFC2HB4I0K (Polychlorinated Biphenyls) RN - 0 (Halogenated Diphenyl Ethers) SB - IM MH - Pregnancy MH - Female MH - Animals MH - Humans MH - Infant MH - *Environmental Pollutants/analysis MH - *Polychlorinated Biphenyls/analysis MH - Biological Monitoring MH - Hair Analysis MH - Spain MH - Halogenated Diphenyl Ethers/analysis MH - Environmental Monitoring/methods OTO - NOTNLM OT - Biomonitoring OT - Hair analysis OT - Mother and infant hair OT - Northwestern Spain OT - Organic pollutants COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2023/10/13 00:42 MHDA- 2023/11/20 06:55 CRDT- 2023/10/12 19:27 PHST- 2023/05/11 00:00 [received] PHST- 2023/08/03 00:00 [revised] PHST- 2023/10/05 00:00 [accepted] PHST- 2023/11/20 06:55 [medline] PHST- 2023/10/13 00:42 [pubmed] PHST- 2023/10/12 19:27 [entrez] AID - S0269-7491(23)01707-4 [pii] AID - 10.1016/j.envpol.2023.122705 [doi] PST - ppublish SO - Environ Pollut. 2023 Dec 15;339:122705. doi: 10.1016/j.envpol.2023.122705. Epub 2023 Oct 10.