PMID- 37827962 OWN - NLM STAT- MEDLINE DCOM- 20231206 LR - 20231217 IS - 1473-0502 (Print) IS - 1473-0502 (Linking) VI - 62 IP - 6 DP - 2023 Dec TI - The world apheresis association registry, 2023 update. PG - 103831 LID - S1473-0502(23)00246-X [pii] LID - 10.1016/j.transci.2023.103831 [doi] AB - The WAA apheresis registry contains data on more than 140,000 apheresis procedures conducted in 12 different countries. The aim is to give an update of indications, type and number of procedures and adverse events (AEs). MATERIAL AND METHODS: The WAA-registry is used for registration of apheresis procedures and is free of charge. The responsible person for a center can apply at the site www.waa-registry.org RESULTS: Data includes reported AEs from 2012 and various procedures and diagnoses during the years 2018-2022; the latter in total from 27 centers registered a total of 9500 patients (41% women) that began therapeutic apheresis (TA) during the period. A total of 58,355 apheresis procedures were performed. The mean age was 50 years (range 0-94). The most common apheresis procedure was stem cell collection for which multiple myeloma was the most frequent diagnosis (51%). Donor cell collection was done in 14% and plasma exchange (PEX) in 28% of patients; In relation to all performed procedures PEX, using a centrifuge (35%) and LDL-apheresis (20%) were the most common. The main indication for PEX was TTP (17%). Peripheral veins were used in 56% as the vascular access. The preferred anticoagulant was ACD. AEs occurred in 2.7% of all procedures and were mostly mild (1%) and moderate 1.5% (needed supportive medication) and, only rarely, severe (0.15%). CONCLUSION: The data showed a wide range of indications and variability in apheresis procedures with low AE frequency. CI - Copyright (c) 2023 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - Vrielink, Hans AU - Vrielink H AD - Unit of Transfusion medicine of Sanquin Blood Supply, Sanquin Blood Supply Foundation in Amsterdam, the Netherlands. FAU - Le Poole, Kaatje AU - Le Poole K AD - Unit of Transfusion medicine of Sanquin Blood Supply, Sanquin Blood Supply Foundation in Amsterdam, the Netherlands. FAU - Stegmayr, Bernd AU - Stegmayr B AD - Public Health and Clinical Medicine, Umea University, Umea, Sweden. Electronic address: bernd.stegmayr@umu.se. FAU - Kielstein, Jan AU - Kielstein J AD - Academic Teaching Hospital Braunschweig, Medical Clinic V - Nephrology, Rheumatology, Blood Purification, Germany. FAU - Berlin, Gosta AU - Berlin G AD - Department of Clinical Immunology and Transfusion Medicine, and Department of Biochemical and Clinical Sciences, Linkoping University, Linkoping, Sweden. FAU - Ilhan, Osman AU - Ilhan O AD - Department Haematology, University Hospital, Ankara, Turkey. FAU - Seval, Guldane Cengiz AU - Seval GC AD - Department Haematology, University Hospital, Ankara, Turkey. FAU - Prophet, Heinrich AU - Prophet H AD - Nephrocare Rostock GmbH, Rostock, Germany. FAU - Aandahl, Astrid AU - Aandahl A AD - Dep of Immunology and Transfusion Medicine, Akershus University Hospital, Lorenskog, Norway. FAU - Deeren, Dries AU - Deeren D AD - AZ Delta, Roeselare, Belgium. FAU - Bojanic, Ines AU - Bojanic I AD - Clinical Department of Transfusion Medicine and Transplantation Biology, University Hospital Centre Zagreb, Croatia. FAU - Blaha, Milan AU - Blaha M AD - IV. Internal Hematological Klinik, Fakultni Nemocnice, Hradec Kralove, Czech Republic. FAU - Lanska, Miriam AU - Lanska M AD - IV. Internal Hematological Klinik, Fakultni Nemocnice, Hradec Kralove, Czech Republic. FAU - Gasova, Zdenka AU - Gasova Z AD - Apheresis Department, Institute of Hematology and Blood Transfusion, Prague, Czech Republic. FAU - Bhuiyan-Ludvikova, Zdenka AU - Bhuiyan-Ludvikova Z AD - Apheresis Department, Institute of Hematology and Blood Transfusion, Prague, Czech Republic. FAU - Blahutova, Sarka AU - Blahutova S AD - Blood Centre, University Hospital Ostrava, Ostrava, Czech Republic. FAU - Hrdlickova, Radomira AU - Hrdlickova R AD - Blood Centre, University Hospital Ostrava, Ostrava, Czech Republic. FAU - Audzijoniene, Judita AU - Audzijoniene J AD - Therapeutic apheresis unit, Vilnius university hospital Santariskiu clinics, Vilnius, Lithuania. FAU - Griskevicius, Antanas AU - Griskevicius A AD - Therapeutic apheresis unit, Vilnius university hospital Santariskiu clinics, Vilnius, Lithuania. FAU - Glatt, Tanya AU - Glatt T AD - South African National Blood Service, Johannesburg, South Africa. FAU - Strineholm, Virginia AU - Strineholm V AD - Apheresis Center, University Hospital, Orebro, Sweden. FAU - Ott, Michael AU - Ott M AD - Public Health and Clinical Medicine, Umea University, Umea, Sweden. FAU - Nilsson, Thomas AU - Nilsson T AD - Department of Nephrology, University Hospital, Uppsala, Sweden. FAU - Newman, Elizabeth AU - Newman E AD - Bone Marrow Transplant & Apheresis, Apheresis & Cell Therapies Unit, Concord Repatriation General Hospital, Concord, NSW, Australia. FAU - Derfler, Kurt AU - Derfler K AD - The Institute for the Diagnosis and Therapy of Atherosclerosis and Fat Metabolism Disorders, Athos, Vienna, Austria. FAU - Witt, Volker AU - Witt V AD - St. Anna Kinderspital, University Hospital, Vienna, Austria. FAU - Toss, Fredrik AU - Toss F AD - Department of Clinical Microbiology, Division of Clinical Immunology, Umea University, Umea, Sweden. LA - eng PT - Journal Article PT - Review DEP - 20231007 PL - England TA - Transfus Apher Sci JT - Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis JID - 101095653 MH - Humans MH - Female MH - Infant, Newborn MH - Infant MH - Child, Preschool MH - Child MH - Adolescent MH - Young Adult MH - Adult MH - Middle Aged MH - Aged MH - Aged, 80 and over MH - Male MH - *Blood Component Removal/methods MH - Plasma Exchange/adverse effects MH - Plasmapheresis MH - Registries MH - Tissue Donors OTO - NOTNLM OT - Adverse events OT - Apheresis OT - Indications OT - Procedures OT - Register EDAT- 2023/10/13 00:43 MHDA- 2023/12/06 06:42 CRDT- 2023/10/12 22:01 PHST- 2023/12/06 06:42 [medline] PHST- 2023/10/13 00:43 [pubmed] PHST- 2023/10/12 22:01 [entrez] AID - S1473-0502(23)00246-X [pii] AID - 10.1016/j.transci.2023.103831 [doi] PST - ppublish SO - Transfus Apher Sci. 2023 Dec;62(6):103831. doi: 10.1016/j.transci.2023.103831. Epub 2023 Oct 7.