PMID- 37831056
OWN - NLM
STAT- MEDLINE
DCOM- 20231023
LR  - 20240210
IS  - 1477-9129 (Electronic)
IS  - 0950-1991 (Print)
IS  - 0950-1991 (Linking)
VI  - 150
IP  - 20
DP  - 2023 Oct 15
TI  - Maternal-fetal cross-talk via the placenta: influence on offspring development 
      and metabolism.
LID - 10.1242/dev.202088 [doi]
LID - dev202088
AB  - Compelling epidemiological and animal experimental data demonstrate that 
      cardiometabolic and neuropsychiatric diseases originate in a suboptimal 
      intrauterine environment. Here, we review evidence suggesting that altered 
      placental function may, at least in part, mediate the link between the maternal 
      environment and changes in fetal growth and development. Emerging evidence 
      indicates that the placenta controls the development and function of several 
      fetal tissues through nutrient sensing, modulation of trophoblast nutrient 
      transporters and by altering the number and cargo of released extracellular 
      vesicles. In this Review, we discuss the development and functions of the 
      maternal-placental-fetal interface (in humans and mice) and how cross-talk 
      between these compartments may be a mechanism for in utero programming, focusing 
      on mechanistic target of rapamycin (mTOR), adiponectin and O-GlcNac transferase 
      (OGT) signaling. We also discuss how maternal diet and stress influences fetal 
      development and metabolism and how fetal growth restriction can result in 
      susceptibility to developing chronic disease later in life. Finally, we speculate 
      how interventions targeting placental function may offer unprecedented 
      opportunities to prevent cardiometabolic disease in future generations.
CI  - (c) 2023. Published by The Company of Biologists Ltd.
FAU - Kramer, Avery C
AU  - Kramer AC
AUID- ORCID: 0000-0002-7839-0606
AD  - Departments of Obstetrics & Gynecology, Psychiatry and Pediatrics, Anschutz 
      Medical Campus, University of Colorado, Aurora, CO 80045, USA.
FAU - Jansson, Thomas
AU  - Jansson T
AD  - Departments of Obstetrics & Gynecology, Psychiatry and Pediatrics, Anschutz 
      Medical Campus, University of Colorado, Aurora, CO 80045, USA.
FAU - Bale, Tracy L
AU  - Bale TL
AD  - Departments of Obstetrics & Gynecology, Psychiatry and Pediatrics, Anschutz 
      Medical Campus, University of Colorado, Aurora, CO 80045, USA.
FAU - Powell, Theresa L
AU  - Powell TL
AUID- ORCID: 0000-0001-7410-1080
AD  - Departments of Obstetrics & Gynecology, Psychiatry and Pediatrics, Anschutz 
      Medical Campus, University of Colorado, Aurora, CO 80045, USA.
LA  - eng
GR  - R01 HD097093/HD/NICHD NIH HHS/United States
GR  - R01 HD104644/HD/NICHD NIH HHS/United States
GR  - R01 HD068370/HD/NICHD NIH HHS/United States
GR  - R01 HD065007/HD/NICHD NIH HHS/United States
GR  - R01 HD105701/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
DEP - 20231013
PL  - England
TA  - Development
JT  - Development (Cambridge, England)
JID - 8701744
SB  - IM
MH  - Pregnancy
MH  - Female
MH  - Humans
MH  - Mice
MH  - Animals
MH  - *Placenta/metabolism
MH  - *Fetal Development
MH  - Trophoblasts/metabolism
MH  - Signal Transduction
MH  - Fetal Growth Retardation
PMC - PMC10617615
OTO - NOTNLM
OT  - Epigenetics
OT  - Extracellular vesicles
OT  - Fetal development
OT  - Maternal-fetal exchange
OT  - Prenatal
OT  - Programming
COIS- Competing interests The authors declare no competing or financial interests.
EDAT- 2023/10/13 12:43
MHDA- 2023/10/23 01:18
PMCR- 2024/10/13
CRDT- 2023/10/13 10:42
PHST- 2024/10/13 00:00 [pmc-release]
PHST- 2023/10/23 01:18 [medline]
PHST- 2023/10/13 12:43 [pubmed]
PHST- 2023/10/13 10:42 [entrez]
AID - 333472 [pii]
AID - DEV202088 [pii]
AID - 10.1242/dev.202088 [doi]
PST - ppublish
SO  - Development. 2023 Oct 15;150(20):dev202088. doi: 10.1242/dev.202088. Epub 2023 
      Oct 13.