PMID- 37832742
OWN - NLM
STAT- MEDLINE
DCOM- 20240226
LR  - 20240226
IS  - 1526-3231 (Electronic)
IS  - 0749-8063 (Linking)
VI  - 40
IP  - 3
DP  - 2024 Mar
TI  - Postoperative Antiosteoporotic Treatment with Zoledronic Acid Improves Rotator 
      Cuff Healing but Does Not Improve Outcomes in Female Patients with Postmenopausal 
      Osteoporosis: A Prospective, Single-Blinded, Randomized Study.
PG  - 714-722
LID - S0749-8063(23)00812-5 [pii]
LID - 10.1016/j.arthro.2023.09.033 [doi]
AB  - PURPOSE: To investigate the effect of the antiosteoporotic agent zoledronic acid 
      (ZA) on rotator cuff healing and clinical outcomes in patients with 
      postmenopausal osteoporosis. METHODS: We prospectively enrolled 138 female 
      patients with postmenopausal osteoporosis who were scheduled to undergo 
      arthroscopic rotator cuff repair (ARCR) from March 2020 to March 2021. Patients 
      were randomly allocated to the ZA group (ARCR followed by intravenous ZA 
      infusions at postoperative Day 1 and 1 year later) and the control group (ARCR 
      alone). All patients were followed up for 24 months. Tendon healing was evaluated 
      by ultrasonography at 6 weeks and 24 months after surgery. The American Shoulder 
      and Elbow Surgeons (ASES) score, Western Ontario Rotator Cuff (WORC) index, and 
      Numeric Rating Scale (NRS) for pain were recorded at each follow-up, and the 
      minimal clinically important difference (MCID) was calculated. RESULTS: A total 
      of 124 patients were included in the final analysis, 61 in the ZA group and 63 in 
      the control group. There was no statistically significant difference in 
      participant characteristics between the 2 groups. The ZA group had a 
      significantly higher tendon healing rate than the control group at 2 years after 
      surgery (odds ratio = 5.0; 95% confidence interval [CI], 1.4-18.7; P = .014). 
      Regarding clinical outcomes, 100% of patients exceeded the MCID in both groups, 
      and no significant differences were found at 2 years after surgery between the 2 
      groups (ASES: 2.5 [95% CI, -2.2 to 7.2; P = .291]; WORC index: 4.5 [95% 
      CI, -0.117 to 9.117; P = .056]; NRS: -0.1 [95% CI, -0.3 to 0.1; P = .394]). 
      CONCLUSIONS: Antiosteoporotic treatment with ZA reduced the retear rate but did 
      not significantly influence the clinical outcomes after ARCR in female patients 
      with postmenopausal osteoporosis. Outcomes of ARCR showed good results in both 
      groups and exceeded the MCID. LEVEL OF EVIDENCE: Level I, randomized controlled 
      trial.
CI  - Copyright (c) 2023 Arthroscopy Association of North America. Published by Elsevier 
      Inc. All rights reserved.
FAU - Lei, Mingjie
AU  - Lei M
AD  - Department of Orthopedics, The First Affiliated Hospital of Chongqing Medical 
      University, Chongqing, China; Orthopedic Laboratory of Chongqing Medical 
      University, Chongqing, China.
FAU - Zhu, Zhenglin
AU  - Zhu Z
AD  - Department of Orthopedics, The First Affiliated Hospital of Chongqing Medical 
      University, Chongqing, China; Orthopedic Laboratory of Chongqing Medical 
      University, Chongqing, China.
FAU - Hu, Xiaobo
AU  - Hu X
AD  - Department of Orthopedics, Chongqing Traditional Chinese Medicine Hospital, 
      Chongqing, China.
FAU - Wu, Dandong
AU  - Wu D
AD  - Department of Rehabilitation, The First Affiliated Hospital of Chongqing Medical 
      University, Chongqing, China.
FAU - Huang, Wei
AU  - Huang W
AD  - Department of Orthopedics, The First Affiliated Hospital of Chongqing Medical 
      University, Chongqing, China; Orthopedic Laboratory of Chongqing Medical 
      University, Chongqing, China.
FAU - Zhang, Yong
AU  - Zhang Y
AD  - Department of Ultrasound, The First Affiliated Hospital of Chongqing Medical 
      University, Chongqing, China.
FAU - Chen, Hong
AU  - Chen H
AD  - Department of Orthopedics, The First Affiliated Hospital of Chongqing Medical 
      University, Chongqing, China; Orthopedic Laboratory of Chongqing Medical 
      University, Chongqing, China. Electronic address: chhong113@126.com.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20231011
PL  - United States
TA  - Arthroscopy
JT  - Arthroscopy : the journal of arthroscopic & related surgery : official 
      publication of the Arthroscopy Association of North America and the International 
      Arthroscopy Association
JID - 8506498
RN  - 6XC1PAD3KF (Zoledronic Acid)
SB  - IM
CIN - Arthroscopy. 2024 Mar;40(3):723-725. PMID: 38219090
MH  - Humans
MH  - Female
MH  - Rotator Cuff/surgery
MH  - *Rotator Cuff Injuries/drug therapy/surgery
MH  - Zoledronic Acid/therapeutic use
MH  - Prospective Studies
MH  - *Osteoporosis, Postmenopausal/drug therapy
MH  - Treatment Outcome
MH  - Arthroscopy/methods
EDAT- 2023/10/14 10:43
MHDA- 2024/02/26 06:45
CRDT- 2023/10/13 19:26
PHST- 2023/06/27 00:00 [received]
PHST- 2023/09/17 00:00 [revised]
PHST- 2023/09/24 00:00 [accepted]
PHST- 2024/02/26 06:45 [medline]
PHST- 2023/10/14 10:43 [pubmed]
PHST- 2023/10/13 19:26 [entrez]
AID - S0749-8063(23)00812-5 [pii]
AID - 10.1016/j.arthro.2023.09.033 [doi]
PST - ppublish
SO  - Arthroscopy. 2024 Mar;40(3):714-722. doi: 10.1016/j.arthro.2023.09.033. Epub 2023 
      Oct 11.