PMID- 37833592
OWN - NLM
STAT- MEDLINE
DCOM- 20231115
LR  - 20231208
IS  - 1614-7499 (Electronic)
IS  - 0944-1344 (Linking)
VI  - 30
IP  - 52
DP  - 2023 Nov
TI  - Association between mixed urinary metal exposure and liver function: analysis of 
      NHANES data.
PG  - 112564-112574
LID - 10.1007/s11356-023-30242-z [doi]
AB  - Metals have been reported to affect liver functions; however, the association 
      between mixed metal exposure in the urine and liver functions remains unclear. 
      The present study analyzed data from the National Health and Nutrition 
      Examination Survey (NHANES) program collected in 2005-2018. Weighted multiple 
      linear regression and Bayesian kernel machine regression (BKMR) were used to 
      explore the relationship between mixed urinary metal contents and liver function 
      tests (LFTs). A total of 8158 participants were analyzed in this study. Multiple 
      methods suggested that cadmium (Cd) was significantly positively related to LFTs, 
      while cobalt (Co) was negatively related to LFTs. Meanwhile, some other metals 
      showed a significant relationship with some indicators of LFTs. Urine metal is 
      related to LFTs, with Cd and Co content changes being closely related to LFTs. 
      The metal in urine may represent a marker for predicting liver dysfunction. 
      Further studies are needed to verify this hypothesis.
CI  - (c) 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, 
      part of Springer Nature.
FAU - Zha, Bowen
AU  - Zha B
AD  - Department of Education, Beijing Anzhen Hospital, Capital Medical University, 
      Beijing, 100069, People's Republic of China.
AD  - Department of Endoscopy, National Cancer Center/National Clinical Research Center 
      for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union 
      Medical College, Beijing, 100021, People's Republic of China.
FAU - Xu, Huanchang
AU  - Xu H
AD  - Department of Education, Beijing Luhe Hospital, Capital Medical University, 
      101149, Beijing, People's Republic of China.
FAU - Liu, Yuqi
AU  - Liu Y
AD  - Department of Education, Beijing Luhe Hospital, Capital Medical University, 
      101149, Beijing, People's Republic of China.
FAU - Zha, Xiaqin
AU  - Zha X
AD  - Department of Blood Purification, University Affiliated Second Hospital, 333000, 
      Nanchang, People's Republic of China. zhaxq1234@163.com.
LA  - eng
PT  - Journal Article
DEP - 20231014
PL  - Germany
TA  - Environ Sci Pollut Res Int
JT  - Environmental science and pollution research international
JID - 9441769
RN  - 00BH33GNGH (Cadmium)
RN  - 0 (Metals)
RN  - 3G0H8C9362 (Cobalt)
SB  - IM
MH  - Humans
MH  - *Cadmium/urine
MH  - Nutrition Surveys
MH  - Bayes Theorem
MH  - *Metals
MH  - Cobalt
MH  - Liver
OTO - NOTNLM
OT  - BKMR
OT  - LFT
OT  - NHANES
OT  - Urinary metal
EDAT- 2023/10/14 10:43
MHDA- 2023/11/15 06:42
CRDT- 2023/10/13 23:49
PHST- 2023/04/11 00:00 [received]
PHST- 2023/09/29 00:00 [accepted]
PHST- 2023/11/15 06:42 [medline]
PHST- 2023/10/14 10:43 [pubmed]
PHST- 2023/10/13 23:49 [entrez]
AID - 10.1007/s11356-023-30242-z [pii]
AID - 10.1007/s11356-023-30242-z [doi]
PST - ppublish
SO  - Environ Sci Pollut Res Int. 2023 Nov;30(52):112564-112574. doi: 
      10.1007/s11356-023-30242-z. Epub 2023 Oct 14.