PMID- 37834889
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231030
IS  - 2077-0383 (Print)
IS  - 2077-0383 (Electronic)
IS  - 2077-0383 (Linking)
VI  - 12
IP  - 19
DP  - 2023 Sep 28
TI  - Utility of Covered Self-Expanding Metal Stents for Biliary Drainage during 
      Neoadjuvant Chemotherapy in Patients with Borderline Resectable Pancreatic 
      Cancer.
LID - 10.3390/jcm12196245 [doi]
LID - 6245
AB  - OBJECTIVES: We aimed to compare the utility of covered self-expanding metal 
      stents (CSEMSs) with that of plastic stents (PSs) for biliary drainage during 
      neoadjuvant chemotherapy in patients with borderline resectable pancreatic 
      cancer. METHODS: Forty patients with borderline resectable pancreatic cancer 
      underwent biliary stenting during neoadjuvant chemotherapy at Hiroshima 
      University Hospital. PSs and CSEMSs were placed in 19 and 21 patients, 
      respectively. Two gemcitabine-based regimens for chemotherapy were used. 
      Treatment outcomes and postoperative complications were compared between both 
      groups. RESULTS: The incidence of recurrent biliary obstruction was significantly 
      lower in the CSEMS group (0% vs. 47.4%, p < 0.001), and the median time to 
      recurrent biliary obstruction in the PS group was 47 days. There was no 
      difference in the incidence of other complications such as non-occlusive 
      cholangitis, pancreatitis, and cholecystitis between the two groups. Delays in 
      the chemotherapy schedule due to stent-related complications were significantly 
      frequent in the PS group (52.6% vs. 4.8%, p = 0.001). There was no significant 
      difference in the incidence of postoperative complications between the two 
      groups. CONCLUSIONS: CSEMSs may be the best choice for safely performing 
      neoadjuvant chemotherapy for several months in patients with borderline 
      resectable pancreatic cancer with bile duct stricture.
FAU - Furukawa, Masaru
AU  - Furukawa M
AD  - Department of Gastroenterology, Graduate School of Biomedical and Health 
      Sciences, Hiroshima University, Hiroshima 734-8551, Japan.
FAU - Ishii, Yasutaka
AU  - Ishii Y
AUID- ORCID: 0000-0003-3545-8743
AD  - Department of Gastroenterology, Graduate School of Biomedical and Health 
      Sciences, Hiroshima University, Hiroshima 734-8551, Japan.
FAU - Serikawa, Masahiro
AU  - Serikawa M
AUID- ORCID: 0000-0001-8350-7947
AD  - Department of Gastroenterology, Graduate School of Biomedical and Health 
      Sciences, Hiroshima University, Hiroshima 734-8551, Japan.
FAU - Tsuboi, Tomofumi
AU  - Tsuboi T
AD  - Department of Gastroenterology, Graduate School of Biomedical and Health 
      Sciences, Hiroshima University, Hiroshima 734-8551, Japan.
FAU - Tatsukawa, Yumiko
AU  - Tatsukawa Y
AD  - Department of Gastroenterology, Graduate School of Biomedical and Health 
      Sciences, Hiroshima University, Hiroshima 734-8551, Japan.
FAU - Hirano, Tetsuro
AU  - Hirano T
AD  - Department of Gastroenterology, Graduate School of Biomedical and Health 
      Sciences, Hiroshima University, Hiroshima 734-8551, Japan.
FAU - Nakamura, Shinya
AU  - Nakamura S
AD  - Department of Gastroenterology, Graduate School of Biomedical and Health 
      Sciences, Hiroshima University, Hiroshima 734-8551, Japan.
FAU - Ikemoto, Juri
AU  - Ikemoto J
AUID- ORCID: 0000-0003-3992-0472
AD  - Department of Gastroenterology, Graduate School of Biomedical and Health 
      Sciences, Hiroshima University, Hiroshima 734-8551, Japan.
FAU - Kiyoshita, Yusuke
AU  - Kiyoshita Y
AD  - Department of Gastroenterology, Graduate School of Biomedical and Health 
      Sciences, Hiroshima University, Hiroshima 734-8551, Japan.
FAU - Saeki, Sho
AU  - Saeki S
AD  - Department of Gastroenterology, Graduate School of Biomedical and Health 
      Sciences, Hiroshima University, Hiroshima 734-8551, Japan.
FAU - Tamura, Yosuke
AU  - Tamura Y
AD  - Department of Gastroenterology, Graduate School of Biomedical and Health 
      Sciences, Hiroshima University, Hiroshima 734-8551, Japan.
FAU - Miyamoto, Sayaka
AU  - Miyamoto S
AD  - Department of Gastroenterology, Graduate School of Biomedical and Health 
      Sciences, Hiroshima University, Hiroshima 734-8551, Japan.
FAU - Nakamura, Kazuki
AU  - Nakamura K
AD  - Department of Gastroenterology, Graduate School of Biomedical and Health 
      Sciences, Hiroshima University, Hiroshima 734-8551, Japan.
FAU - Yamashita, Yumiko
AU  - Yamashita Y
AD  - Department of Gastroenterology, Graduate School of Biomedical and Health 
      Sciences, Hiroshima University, Hiroshima 734-8551, Japan.
FAU - Iijima, Noriaki
AU  - Iijima N
AD  - Department of Gastroenterology, Graduate School of Biomedical and Health 
      Sciences, Hiroshima University, Hiroshima 734-8551, Japan.
FAU - Uemura, Kenichiro
AU  - Uemura K
AD  - Department of Surgery, Graduate School of Biomedical and Health Sciences, 
      Hiroshima University, Hiroshima 734-8551, Japan.
FAU - Oka, Shiro
AU  - Oka S
AD  - Department of Gastroenterology, Graduate School of Biomedical and Health 
      Sciences, Hiroshima University, Hiroshima 734-8551, Japan.
LA  - eng
PT  - Journal Article
DEP - 20230928
PL  - Switzerland
TA  - J Clin Med
JT  - Journal of clinical medicine
JID - 101606588
PMC - PMC10573529
OTO - NOTNLM
OT  - neoadjuvant chemotherapy
OT  - pancreatic cancer
OT  - self-expanding metal stent
COIS- The authors declare no conflict of interest.
EDAT- 2023/10/14 10:45
MHDA- 2023/10/14 10:46
PMCR- 2023/09/28
CRDT- 2023/10/14 01:08
PHST- 2023/08/03 00:00 [received]
PHST- 2023/09/01 00:00 [revised]
PHST- 2023/09/26 00:00 [accepted]
PHST- 2023/10/14 10:46 [medline]
PHST- 2023/10/14 10:45 [pubmed]
PHST- 2023/10/14 01:08 [entrez]
PHST- 2023/09/28 00:00 [pmc-release]
AID - jcm12196245 [pii]
AID - jcm-12-06245 [pii]
AID - 10.3390/jcm12196245 [doi]
PST - epublish
SO  - J Clin Med. 2023 Sep 28;12(19):6245. doi: 10.3390/jcm12196245.