PMID- 37836307
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231020
IS  - 2079-4991 (Print)
IS  - 2079-4991 (Electronic)
IS  - 2079-4991 (Linking)
VI  - 13
IP  - 19
DP  - 2023 Sep 28
TI  - Graphene Oxide Nanostructures as Nanoplatforms for Delivering Natural Therapeutic 
      Agents: Applications in Cancer Treatment, Bacterial Infections, and Bone 
      Regeneration Medicine.
LID - 10.3390/nano13192666 [doi]
LID - 2666
AB  - Graphene, fullerenes, diamond, carbon nanotubes, and carbon dots are just a few 
      of the carbon-based nanomaterials that have gained enormous popularity in a 
      variety of scientific disciplines and industrial uses. As a two-dimensional 
      material in the creation of therapeutic delivery systems for many illnesses, 
      nanosized graphene oxide (NGO) is now garnering a large amount of attention among 
      these materials. In addition to other benefits, NGO functions as a drug 
      nanocarrier with remarkable biocompatibility, high pharmaceutical loading 
      capacity, controlled drug release capability, biological imaging efficiency, 
      multifunctional nanoplatform properties, and the power to increase the 
      therapeutic efficacy of loaded agents. Thus, NGO is a perfect nanoplatform for 
      the development of drug delivery systems (DDSs) to both detect and treat a 
      variety of ailments. This review article's main focus is on investigating surface 
      functionality, drug-loading methods, and drug release patterns designed 
      particularly for smart delivery systems. The paper also examines the relevance of 
      using NGOs to build DDSs and considers prospective uses in the treatment of 
      diseases including cancer, infection by bacteria, and bone regeneration medicine. 
      These factors cover the use of naturally occurring medicinal substances produced 
      from plant-based sources.
FAU - AbouAitah, Khaled
AU  - AbouAitah K
AUID- ORCID: 0000-0001-8413-6738
AD  - Department of Chemical Engineering, Chungbuk National University, Cheongju 28644, 
      Republic of Korea.
AD  - Medicinal and Aromatic Plants Research Department, Pharmaceutical and Drug 
      Industries Research Institute, National Research Centre (NRC), 33 El-Behouth 
      Street, Dokki, Giza 12622, Egypt.
FAU - Sabbagh, Farzaneh
AU  - Sabbagh F
AUID- ORCID: 0000-0002-2274-3855
AD  - Department of Chemical Engineering, Chungbuk National University, Cheongju 28644, 
      Republic of Korea.
FAU - Kim, Beom Soo
AU  - Kim BS
AUID- ORCID: 0000-0002-7251-7231
AD  - Department of Chemical Engineering, Chungbuk National University, Cheongju 28644, 
      Republic of Korea.
LA  - eng
GR  - 2022H1D3A2A02090010/National Research Foundation of Korea/
PT  - Journal Article
PT  - Review
DEP - 20230928
PL  - Switzerland
TA  - Nanomaterials (Basel)
JT  - Nanomaterials (Basel, Switzerland)
JID - 101610216
PMC - PMC10574074
OTO - NOTNLM
OT  - bacterial infections
OT  - bone regeneration medicine
OT  - cancer therapy
OT  - delivery systems
OT  - nanoformulations
OT  - nanographene oxide
OT  - natural agents
OT  - natural compounds
COIS- The authors declare no conflict of interest.
EDAT- 2023/10/14 10:44
MHDA- 2023/10/14 10:45
PMCR- 2023/09/28
CRDT- 2023/10/14 01:17
PHST- 2023/08/25 00:00 [received]
PHST- 2023/09/23 00:00 [revised]
PHST- 2023/09/26 00:00 [accepted]
PHST- 2023/10/14 10:45 [medline]
PHST- 2023/10/14 10:44 [pubmed]
PHST- 2023/10/14 01:17 [entrez]
PHST- 2023/09/28 00:00 [pmc-release]
AID - nano13192666 [pii]
AID - nanomaterials-13-02666 [pii]
AID - 10.3390/nano13192666 [doi]
PST - epublish
SO  - Nanomaterials (Basel). 2023 Sep 28;13(19):2666. doi: 10.3390/nano13192666.