PMID- 37836472
OWN - NLM
STAT- MEDLINE
DCOM- 20231023
LR  - 20231023
IS  - 2072-6643 (Electronic)
IS  - 2072-6643 (Linking)
VI  - 15
IP  - 19
DP  - 2023 Sep 28
TI  - Aronia in the Type 2 Diabetes Treatment Regimen.
LID - 10.3390/nu15194188 [doi]
LID - 4188
AB  - Aronia melanocarpa berries are rich in antioxidants and possess a high 
      antioxidant capacity. Aronia berries have shown potential in type 2 diabetes 
      mellitus (T2DM) treatment, and previous studies indicate improvements in glycemia 
      after supplementation. Unfortunately, the effectiveness of aronia berries is 
      limited by the low bioavailability of aronia, which fermentation could 
      potentially overcome. The objective of this study was to compare the effects of 
      fermented or non-fermented aronia pulp with placebo in subjects with T2DM. This 
      study was a triple-blinded, triple-crossover study with eight-week intervention 
      periods with fermented aronia extract (FAE), non-fermented aronia extract (AE), 
      and placebo. Extracts were incorporated in snack bars with 37% aronia (FAE or AE) 
      or wheat bran (placebo) and 63% raisins and coconut oil. Pre- and post-treatment 
      period, we did fasting blood samples, including hemoglobin A1c, fructosamine, 
      insulin, glucose, glucagon-like peptide-1, glucose-dependent insulinotropic 
      peptide (GIP) and glucagon, oral glucose tolerance tests, and anthropometric 
      measurements. Of 36 randomized participants, 23 completed the trial. Aside from a 
      higher increase in GIP after FAE supplementation compared to after placebo 
      supplementation, aronia extracts had no effect. The increase in GIP levels after 
      FAE supplementation may hold potential benefits, but the overall clinical impact 
      remains unclear.
FAU - Christiansen, Christine B
AU  - Christiansen CB
AUID- ORCID: 0000-0001-6381-5360
AD  - Department of Clinical Medicine, Aarhus University, Palle Juul-Jensens Boulevard 
      11, 8200 Aarhus N, Denmark.
FAU - Jeppesen, Per B
AU  - Jeppesen PB
AUID- ORCID: 0000-0001-8042-7554
AD  - Department of Clinical Medicine, Aarhus University, Palle Juul-Jensens Boulevard 
      11, 8200 Aarhus N, Denmark.
FAU - Hermansen, Kjeld
AU  - Hermansen K
AD  - Department of Clinical Medicine, Aarhus University, Palle Juul-Jensens Boulevard 
      11, 8200 Aarhus N, Denmark.
AD  - Department of Endocrinology and Internal Medicine, Aarhus University Hospital, 
      Palle Juul-Jensens Boulevard 99, 8200 Aarhus N, Denmark.
FAU - Gregersen, Soren
AU  - Gregersen S
AD  - Department of Clinical Medicine, Aarhus University, Palle Juul-Jensens Boulevard 
      11, 8200 Aarhus N, Denmark.
AD  - Steno Diabetes Center Aarhus, Palle Juul-Jensens Boulevard 11, 8200 Aarhus N, 
      Denmark.
LA  - eng
GR  - 9065-00126B/Innovation Fund Denmark/
GR  - NNF17SA0031406/Danish Diabetes Academy/
GR  - 2019-04/Ekhaga Foundation/
GR  - 19-B-0179/Helsefonden/
GR  - Future Food innovation/
GR  - Aase og Ejnar Danielsens Fond/
GR  - A.P. Moller og Hustru Chastine Mc-Kinney Mollers Fond/
GR  - Frode V. Nyegaard og Hustru's Fond/
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20230928
PL  - Switzerland
TA  - Nutrients
JT  - Nutrients
JID - 101521595
RN  - 0 (Antioxidants)
RN  - 0 (Insulin)
RN  - 0 (Plant Extracts)
SB  - IM
MH  - Humans
MH  - *Diabetes Mellitus, Type 2/drug therapy
MH  - *Photinia
MH  - Cross-Over Studies
MH  - Antioxidants/therapeutic use/pharmacology
MH  - Insulin
MH  - Plant Extracts/therapeutic use/pharmacology
PMC - PMC10574687
OTO - NOTNLM
OT  - Aronia melanocarpa
OT  - anthocyanins
OT  - antioxidants
OT  - dietary supplement
OT  - polyphenols
OT  - randomized controlled trial
OT  - type 2 diabetes
COIS- The authors declare no conflict of interest.
EDAT- 2023/10/14 10:48
MHDA- 2023/10/23 01:18
PMCR- 2023/09/28
CRDT- 2023/10/14 01:18
PHST- 2023/09/13 00:00 [received]
PHST- 2023/09/22 00:00 [revised]
PHST- 2023/09/24 00:00 [accepted]
PHST- 2023/10/23 01:18 [medline]
PHST- 2023/10/14 10:48 [pubmed]
PHST- 2023/10/14 01:18 [entrez]
PHST- 2023/09/28 00:00 [pmc-release]
AID - nu15194188 [pii]
AID - nutrients-15-04188 [pii]
AID - 10.3390/nu15194188 [doi]
PST - epublish
SO  - Nutrients. 2023 Sep 28;15(19):4188. doi: 10.3390/nu15194188.