PMID- 37837582
OWN - NLM
STAT- MEDLINE
DCOM- 20231115
LR  - 20231208
IS  - 1614-7499 (Electronic)
IS  - 0944-1344 (Linking)
VI  - 30
IP  - 52
DP  - 2023 Nov
TI  - Association between exposure to multiple polyaromatic hydrocarbons and 
      periodontitis: findings from a cross-sectional study.
PG  - 112611-112624
LID - 10.1007/s11356-023-29421-9 [doi]
AB  - The impact of environmental pollutant exposure on periodontitis has raised 
      significant concerns. But the association between exposure to multiple 
      polyaromatic hydrocarbons (PAHs) and periodontitis still remained unclear. Our 
      study investigated the association of exposure to multiple PAHs with 
      periodontitis. A total of 1880 participants from the National Health and 
      Nutrition Examination Survey (NHANES) were included in this study. Urinary 
      samples of the participants exposed to six PAHs, namely, 1-hydroxynaphthalene 
      (1-OHN), 2-hydroxynaphthalene (2-OHN), 3-hydroxyfluorene (3-OHF), 
      2-hydroxyfluorene (2-OHF), 1-hydroxyphenanthrene (1-OHPhe), and 1-hydroxypyrene 
      (1-OHPyr), were investigated. Multiple logistic regression, restricted cubic 
      spline, and Bayesian kernel machine regression (BKMR) models were employed to 
      identify the association between PAH exposures and periodontitis. The 
      dose-response analysis exhibited a gradual increase in the periodontitis risk 
      with an increase in multiple PAHs. After adjustment for several potential 
      confounders, the odds ratio of the highest quartile (Quartile 4) was 1.648 (95% 
      confidence interval (CI) 1.108-2.456, P = 0.014, P-t = 0.017) for 2-OHN, 2.046 
      (95%CI 1.352-3.104, P < 0.001, P-t = 0.005) for 3-OHF, 1.996 (95% CI 1.310-3.046, 
      P = 0.001, P-t = 0.003) for 2-OHF, 1.789 (95% CI 1.230-2.604, P = 0.002, 
      P-t = 0.003) for 1-OHPhe, and 1.494 (95% CI 1.025-2.181, P = 0.037, P-t = 0.021) 
      for 1-OHPyr compared with that of the lowest quartile (Quartile 1). BKMR 
      illustrated that the overall effect of the PAH mixture was positively related to 
      periodontitis. Mediation analysis identified blood neutrophils as a partial 
      mediator of 3-OHF and 2-OHF. Exposure to multiple PAHs was positively associated 
      with periodontitis in US adults, and blood neutrophils mediate the effects of 
      3-OHF and 2-OHF therein.
CI  - (c) 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, 
      part of Springer Nature.
FAU - Lin, Fei
AU  - Lin F
AD  - Department of Stomatology, Fujian Medical University Union Hospital, Fuzhou, 
      35001, China.
FAU - Wang, Huaicheng
AU  - Wang H
AD  - Fujian Medical University, Fuzhou, 35001, China.
FAU - Wang, Xuefei
AU  - Wang X
AD  - Fujian Medical University, Fuzhou, 35001, China.
FAU - Fang, Yihong
AU  - Fang Y
AD  - Department of Stomatology, Fujian Medical University Union Hospital, Fuzhou, 
      35001, China. fjxhcsxd@163.com.
LA  - eng
GR  - 2022J01746/Fujian Natural Science Foundation Project/
PT  - Journal Article
DEP - 20231014
PL  - Germany
TA  - Environ Sci Pollut Res Int
JT  - Environmental science and pollution research international
JID - 9441769
RN  - 0 (Polycyclic Aromatic Hydrocarbons)
RN  - 0 (Biomarkers)
RN  - 0 (Hydrocarbons, Aromatic)
RN  - 0 (Environmental Pollutants)
SB  - IM
MH  - Adult
MH  - Humans
MH  - *Polycyclic Aromatic Hydrocarbons
MH  - Cross-Sectional Studies
MH  - Nutrition Surveys
MH  - Bayes Theorem
MH  - Biomarkers
MH  - *Hydrocarbons, Aromatic
MH  - *Environmental Pollutants
OTO - NOTNLM
OT  - BKMR
OT  - NHANES
OT  - Periodontitis
OT  - Polyaromatic hydrocarbons
EDAT- 2023/10/15 05:42
MHDA- 2023/11/15 06:43
CRDT- 2023/10/14 11:17
PHST- 2023/05/11 00:00 [received]
PHST- 2023/08/17 00:00 [accepted]
PHST- 2023/11/15 06:43 [medline]
PHST- 2023/10/15 05:42 [pubmed]
PHST- 2023/10/14 11:17 [entrez]
AID - 10.1007/s11356-023-29421-9 [pii]
AID - 10.1007/s11356-023-29421-9 [doi]
PST - ppublish
SO  - Environ Sci Pollut Res Int. 2023 Nov;30(52):112611-112624. doi: 
      10.1007/s11356-023-29421-9. Epub 2023 Oct 14.