PMID- 37837670
OWN - NLM
STAT- MEDLINE
DCOM- 20231205
LR  - 20231228
IS  - 1872-7603 (Electronic)
IS  - 0165-0378 (Linking)
VI  - 160
DP  - 2023 Dec
TI  - Upregulation of autotaxin by oxidative stress via Nrf2 activation: A novel 
      insight into the compensation mechanism in preeclamptic placenta.
PG  - 104153
LID - S0165-0378(23)00359-5 [pii]
LID - 10.1016/j.jri.2023.104153 [doi]
AB  - The response of autotaxin (ATX)-lysophosphatidic acid (LPA) signaling system to 
      placental oxidative stress (OS) and its significance to preeclampsia were 
      investigated. For this purpose, oxidative stress index (OSI) and ATX levels were 
      measured in the serum of pregnant women with preeclampsia. The expression levels 
      of ATX and LPA receptors were assessed in trophoblast cells under high OS and 
      glucose deprivation/re-oxygenation (OGD/R) conditions, with particular emphasis 
      on the antioxidative nuclear factor erythroid 2-related factor 2 (NRF2) pathway. 
      The influence of ATX-LPA signaling on cell migration was also evaluated using the 
      wound healing assay. ATX concentrations and OSI in the serum were found to be 
      elevated in preeclamptic women. The serum ATX levels were also positively 
      correlated with OSI. Trophoblast cells responded to OS by increasing ATX mRNA 
      expression concomitantly with intranuclear translocation of Nrf2, whereas 
      inhibition of Nrf2 activation reverted this effect. The ATX-LPA signaling pathway 
      facilitated trophoblast cell motility after Nrf2 activation. In conclusion, OS 
      accumulation in preeclamptic placenta may activate the ATX-LPA system in 
      trophoblasts via the Nrf2 pathway to sustain trophoblast functionality.
CI  - Copyright (c) 2023. Published by Elsevier B.V.
FAU - Yanagisawa, Manami
AU  - Yanagisawa M
AD  - Department of Obstetrics and Gynecology, Faculty of Medicine, The University of 
      Tokyo, Tokyo, Japan.
FAU - Nagamatsu, Takeshi
AU  - Nagamatsu T
AD  - Department of Obstetrics and Gynecology, International University of Health and 
      Welfare, Japan. Electronic address: tnag-tky@iuhw.ac.jp.
FAU - Kurano, Makoto
AU  - Kurano M
AD  - Department of Clinical Laboratory, Faculty of Medicine, The University of Tokyo, 
      Tokyo, Japan.
FAU - Misumi, Fumi
AU  - Misumi F
AD  - Department of Obstetrics and Gynecology, Faculty of Medicine, The University of 
      Tokyo, Tokyo, Japan.
FAU - Taguchi, Ayumi
AU  - Taguchi A
AD  - Department of Obstetrics and Gynecology, Faculty of Medicine, The University of 
      Tokyo, Tokyo, Japan.
FAU - Akiba, Naoya
AU  - Akiba N
AD  - Department of Obstetrics and Gynecology, International University of Health and 
      Welfare, Japan.
FAU - Ichinose, Mari
AU  - Ichinose M
AD  - Department of Obstetrics and Gynecology, Faculty of Medicine, The University of 
      Tokyo, Tokyo, Japan.
FAU - Kumasawa, Keiichi
AU  - Kumasawa K
AD  - Department of Obstetrics and Gynecology, Faculty of Medicine, The University of 
      Tokyo, Tokyo, Japan.
FAU - Iriyama, Takayuki
AU  - Iriyama T
AD  - Department of Obstetrics and Gynecology, Faculty of Medicine, The University of 
      Tokyo, Tokyo, Japan.
FAU - Fujii, Tomoyuki
AU  - Fujii T
AD  - Department of Obstetrics and Gynecology, Faculty of Medicine, The University of 
      Tokyo, Tokyo, Japan.
FAU - Yatomi, Yutaka
AU  - Yatomi Y
AD  - Department of Clinical Laboratory, Faculty of Medicine, The University of Tokyo, 
      Tokyo, Japan.
FAU - Osuga, Yutaka
AU  - Osuga Y
AD  - Department of Obstetrics and Gynecology, Faculty of Medicine, The University of 
      Tokyo, Tokyo, Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230917
PL  - Ireland
TA  - J Reprod Immunol
JT  - Journal of reproductive immunology
JID - 8001906
RN  - 0 (NF-E2-Related Factor 2)
SB  - IM
MH  - Female
MH  - Humans
MH  - Pregnancy
MH  - *Placenta/metabolism
MH  - NF-E2-Related Factor 2/metabolism
MH  - *Pre-Eclampsia/metabolism
MH  - Up-Regulation
MH  - Oxidative Stress
OTO - NOTNLM
OT  - Autotaxin
OT  - Lysophosphatidic acid
OT  - Oxidative stress
OT  - Placenta
OT  - Preeclampsia
OT  - Pregnancy
COIS- Declaration of Competing Interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2023/10/15 05:45
MHDA- 2023/12/05 12:42
CRDT- 2023/10/14 18:00
PHST- 2023/06/06 00:00 [received]
PHST- 2023/09/11 00:00 [revised]
PHST- 2023/09/14 00:00 [accepted]
PHST- 2023/12/05 12:42 [medline]
PHST- 2023/10/15 05:45 [pubmed]
PHST- 2023/10/14 18:00 [entrez]
AID - S0165-0378(23)00359-5 [pii]
AID - 10.1016/j.jri.2023.104153 [doi]
PST - ppublish
SO  - J Reprod Immunol. 2023 Dec;160:104153. doi: 10.1016/j.jri.2023.104153. Epub 2023 
      Sep 17.