PMID- 3783774
OWN - NLM
STAT- MEDLINE
DCOM- 19870120
LR  - 20061115
IS  - 0098-4108 (Print)
IS  - 0098-4108 (Linking)
VI  - 19
IP  - 4
DP  - 1986
TI  - Contamination of platelet storage bags by phthalate esters.
PG  - 591-8
AB  - Phthalate esters are the most extensively used plasticizers in the manufacture of 
      polyvinylchloride (PVC) plastic. Many medical devices used in the collection and 
      storage of blood components are made of PVC plastic containing di(2-ethylhexyl) 
      phthalate (DEHP). DEHP leaches at a rate of 100 micrograms/ml X d into platelet 
      concentrate (PC) supernatant when PCs are stored in PVC containers. It is only 
      possible to store PCs for 72 h in this DEHP plastic, after which time the 
      platelet function has deteriorated and they cannot be used for transfusion 
      therapy. Since it was desirable to find a container that permitted longer storage 
      times and because of the concern for the toxicity of DEHP, new bags, manufactured 
      with different plastic formulations without this plasticizer, were tested for PC 
      storage. Using these new containers, such as the PL732 [polyolefin (PO) plastic], 
      and the CLX300 and PL1240 [tri(2-ethylhexyl) trimellitate (TEHTM) PVC plastic], 
      it was possible to store PCs for 5 d while preserving platelet function. In spite 
      of these new plastic bags being manufactured without DEHP, we found DEHP and its 
      metabolite mono(2-ethylhexyl) phthalate (MEHP) as contaminants of the supernatant 
      of the PCs stored in these containers. After analyzing the plastic material of 
      each of these containers, we were able to identify the source of the 
      contamination as coming from the plastic materials that were used in the 
      manufacture of the bags. The sterilization process of the PL732 bag was 
      investigated, since it was found that when the plastic of the PL732 bag was 
      analyzed prior to sterilization, no contamination by DEHP was detected; however, 
      whether the PL732 bag was sterilized together with the primary PVC bag or 
      separately, using ethylene oxide, contamination by DEHP was found, suggesting 
      contamination of the sterilization unit by DEHP.
FAU - Labow, R S
AU  - Labow RS
FAU - Tocchi, M
AU  - Tocchi M
FAU - Rock, G
AU  - Rock G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Toxicol Environ Health
JT  - Journal of toxicology and environmental health
JID - 7513622
RN  - 0 (Phthalic Acids)
RN  - 0 (Plasticizers)
RN  - 0 (Plastics)
SB  - IM
MH  - *Blood Platelets
MH  - Blood Preservation/*methods
MH  - Phthalic Acids/*analysis
MH  - Plasticizers/*analysis
MH  - Plastics/*analysis
MH  - Solubility
MH  - Sterilization
EDAT- 1986/01/01 00:00
MHDA- 1986/01/01 00:01
CRDT- 1986/01/01 00:00
PHST- 1986/01/01 00:00 [pubmed]
PHST- 1986/01/01 00:01 [medline]
PHST- 1986/01/01 00:00 [entrez]
AID - 10.1080/15287398609530955 [doi]
PST - ppublish
SO  - J Toxicol Environ Health. 1986;19(4):591-8. doi: 10.1080/15287398609530955.