PMID- 37838157
OWN - NLM
STAT- MEDLINE
DCOM- 20231225
LR  - 20231225
IS  - 1538-2990 (Electronic)
IS  - 0002-9629 (Linking)
VI  - 367
IP  - 1
DP  - 2024 Jan
TI  - The expanding role of HLA gene tests for predicting drug side effects.
PG  - 14-20
LID - S0002-9629(23)01375-7 [pii]
LID - 10.1016/j.amjms.2023.10.004 [doi]
AB  - Adverse drug reactions can be either dose-dependent (Type A) or idiosyncratic 
      (Type B). Type B adverse drug reactions tend to be extremely rare and difficult 
      to predict. They are usually immune-mediated. Examples include severe skin 
      reactions and drug-induced liver injury. For many commonly prescribed drugs (such 
      as antibiotics), the risk of developing an idiosyncratic adverse drug reaction is 
      influenced by variability in the human leukocyte antigen (HLA) genes. Because 
      these HLA-mediated adverse drug reactions can be lethal, there is growing 
      interest in defining which specific drug-gene relationships might benefit from 
      pre-emptive HLA genotyping and automated clinical decision support. This review 
      summarizes the literature for HLA-mediated adverse reactions linked to common 
      drugs.
CI  - Copyright (c) 2023 Southern Society for Clinical Investigation. Published by 
      Elsevier Inc. All rights reserved.
FAU - Petry, Natasha
AU  - Petry N
AD  - School of Pharmacy, North Dakota State University, Fargo, ND 58102, USA.
FAU - Forest, Kennedy
AU  - Forest K
AD  - Sanford School of Medicine, University of South Dakota, Sioux Falls, SD, USA.
FAU - Wilke, Russell A
AU  - Wilke RA
AD  - Sanford School of Medicine, University of South Dakota, Sioux Falls, SD, USA. 
      Electronic address: russell.wilke@usd.edu.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20231012
PL  - United States
TA  - Am J Med Sci
JT  - The American journal of the medical sciences
JID - 0370506
RN  - 0 (HLA Antigens)
RN  - 0 (Anti-Bacterial Agents)
SB  - IM
MH  - Humans
MH  - HLA Antigens/genetics/pharmacology
MH  - *Drug-Related Side Effects and Adverse Reactions/diagnosis/genetics
MH  - *Chemical and Drug Induced Liver Injury/etiology/genetics
MH  - Skin
MH  - Anti-Bacterial Agents
OTO - NOTNLM
OT  - Adverse drug reaction
OT  - Decision support
OT  - Pharmacogenetics
EDAT- 2023/10/15 05:45
MHDA- 2023/12/25 06:41
CRDT- 2023/10/14 19:26
PHST- 2023/08/23 00:00 [received]
PHST- 2023/10/09 00:00 [accepted]
PHST- 2023/12/25 06:41 [medline]
PHST- 2023/10/15 05:45 [pubmed]
PHST- 2023/10/14 19:26 [entrez]
AID - S0002-9629(23)01375-7 [pii]
AID - 10.1016/j.amjms.2023.10.004 [doi]
PST - ppublish
SO  - Am J Med Sci. 2024 Jan;367(1):14-20. doi: 10.1016/j.amjms.2023.10.004. Epub 2023 
      Oct 12.