PMID- 37839491
OWN - NLM
STAT- MEDLINE
DCOM- 20231127
LR  - 20231127
IS  - 1879-1026 (Electronic)
IS  - 0048-9697 (Linking)
VI  - 907
DP  - 2024 Jan 10
TI  - Environmental exposure to legacy and emerging per- and polyfluoroalkyl substances 
      and endometriosis in women of childbearing age.
PG  - 167838
LID - S0048-9697(23)06465-3 [pii]
LID - 10.1016/j.scitotenv.2023.167838 [doi]
AB  - Per- and polyfluoroalkyl substances (PFAS) are man-made chemicals known for their 
      adverse effects on humans. Growing concern has risen regarding the reproductive 
      toxicity of PFAS, but whether PFAS affect endometriosis remains to be explored. 
      This hospital-based case-control study included 240 laparoscopic-confirmed 
      endometriosis cases and 334 normal controls in China from 2014 to 2018. 
      Concentrations of thirty-three legacy and emerging PFAS were measured in the 
      plasma samples. Associations between single PFAS and endometriosis were estimated 
      by binary logistic regression. The elastic net regression (ENR) model was used to 
      identify dominant PFAS related to endometriosis. The joint effect of the PFAS 
      mixture on endometriosis was assessed by principal component analysis (PCA), 
      Bayesian kernel machine regression (BKMR), and quantile-based g-computation 
      (q-gcomp). In the single-PFAS model, significant positive associations of PFOA 
      [adjusted odds ratio (95 % CI): 1.22 (1.00, 1.51)], total PFOS [1.19 (1.05, 
      1.34)] and two branched PFOS isomers [1.16 (1.09, 1.22) for 1m-PFOS; 1.18 (1.04, 
      1.34) for 6m-PFOS] with increased endometriosis odds were observed. Mixture 
      models showed that the joint effect of PFAS mixture on endometriosis was 
      significant [1.24 (1.05, 1.48)], mainly driven by 1m-PFOS. The PFOS isomers 
      profile suggested a PFOS precursor biotransformation source of 1m-PFOS in our 
      population. Our study suggests that branched isomers of PFOS may be associated 
      with endometriosis.
CI  - Copyright (c) 2023 Elsevier B.V. All rights reserved.
FAU - Ao, Junjie
AU  - Ao J
AD  - Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, 
      Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 
      200092, China.
FAU - Zhang, Rongrong
AU  - Zhang R
AD  - Department of Obstetrics and Gynecology, Xinhua Hospital, Shanghai Jiao Tong 
      University School of Medicine, Shanghai 200092, China.
FAU - Huo, Xiaona
AU  - Huo X
AD  - International Peace Maternity and Child Health Hospital, Shanghai Jiao Tong 
      University School of Medicine, Shanghai 200030, China.
FAU - Zhu, Wenting
AU  - Zhu W
AD  - Key Laboratory of Reproductive Genetics (Ministry of Education), Department of 
      Reproductive Endocrinology, Women's Hospital, Zhejiang University School of 
      Medicine, Hangzhou 310006, China.
FAU - Zhang, Jun
AU  - Zhang J
AD  - Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, 
      Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 
      200092, China; International Peace Maternity and Child Health Hospital, Shanghai 
      Jiao Tong University School of Medicine, Shanghai 200030, China. Electronic 
      address: junjimzhang@sjtu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20231014
PL  - Netherlands
TA  - Sci Total Environ
JT  - The Science of the total environment
JID - 0330500
RN  - 0 (Environmental Pollutants)
RN  - 0 (Alkanesulfonic Acids)
RN  - 0 (Fluorocarbons)
SB  - IM
MH  - Humans
MH  - Female
MH  - *Endometriosis/chemically induced/epidemiology
MH  - Case-Control Studies
MH  - Bayes Theorem
MH  - *Environmental Pollutants/toxicity
MH  - *Alkanesulfonic Acids/toxicity
MH  - *Fluorocarbons/toxicity
MH  - Environmental Exposure
OTO - NOTNLM
OT  - Branched isomers
OT  - Endometriosis
OT  - Mixture
OT  - Per- and polyfluoroalkyl substances
COIS- Declaration of competing interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2023/10/16 00:42
MHDA- 2023/11/27 12:42
CRDT- 2023/10/15 19:24
PHST- 2023/07/28 00:00 [received]
PHST- 2023/10/07 00:00 [revised]
PHST- 2023/10/12 00:00 [accepted]
PHST- 2023/11/27 12:42 [medline]
PHST- 2023/10/16 00:42 [pubmed]
PHST- 2023/10/15 19:24 [entrez]
AID - S0048-9697(23)06465-3 [pii]
AID - 10.1016/j.scitotenv.2023.167838 [doi]
PST - ppublish
SO  - Sci Total Environ. 2024 Jan 10;907:167838. doi: 10.1016/j.scitotenv.2023.167838. 
      Epub 2023 Oct 14.