PMID- 37839878
OWN - NLM
STAT- MEDLINE
DCOM- 20240515
LR  - 20240515
IS  - 1349-7235 (Electronic)
IS  - 0918-2918 (Linking)
VI  - 63
IP  - 10
DP  - 2024 May 15
TI  - Low Daily Step Count Associated with Small Erector Spinae Muscle Area and 
      Sarcopenia in Idiopathic Pulmonary Fibrosis.
PG  - 1345-1352
LID - 10.2169/internalmedicine.2584-23 [doi]
AB  - Objective The daily step count is associated with mortality in idiopathic 
      pulmonary fibrosis (IPF). However, the factors associated with this phenomenon 
      are not yet fully understood. We therefore clarified its association with 
      clinical parameters. Methods Fifty-nine patients with IPF with available data for 
      daily step counts; 6-minute walk distance (6MWD); chest, abdominal, and pelvic 
      computed tomography (CT); pulmonary function; psychological evaluations; and 
      sarcopenia assessments were prospectively enrolled. The daily step count was 
      measured continuously for seven consecutive days. The cross-sectional areas of 
      the erector spinae muscles at the level of the 12th vertebra (ESM(CSA)) and psoas 
      major muscle volume (PMV) obtained by CT were assessed. Results The average age 
      of the patients was 73.3+/-8.1 years old, and the percent predicted forced vital 
      capacity was 81.6%+/-15.8%. The median daily step count was 4,258 (2,155-6,991) 
      steps. The average 6MWD, ESM(CSA), and PMV were 413+/-97 m, 25.5+/-6.7 cm(2), and 
      270+/-75.6 cm(3), respectively. A linear regression analysis for daily step count 
      showed that the ESM(CSA) and 6MWD were independent factors for the daily step 
      count, whereas the PMV and skeletal muscle index were not. The daily step count, 
      ESM(CSA), and 6MWD were lower in patients with sarcopenia than in those without 
      sarcopenia. Conclusion A lower daily step count was associated with a smaller 
      erector spinae muscle area and sarcopenia in patients with IPF. Further studies 
      are warranted to confirm the importance of physical therapy for muscle 
      strengthening in patients with IPF.
FAU - Ohkubo, Hirotsugu
AU  - Ohkubo H
AD  - Department of Respiratory Medicine, Allergy and Clinical Immunology, Nagoya City 
      University Graduate School of Medical Sciences, Japan.
FAU - Fujita, Kohei
AU  - Fujita K
AD  - Department of Respiratory Medicine, Allergy and Clinical Immunology, Nagoya City 
      University Graduate School of Medical Sciences, Japan.
FAU - Ito, Keima
AU  - Ito K
AD  - Department of Respiratory Medicine, Allergy and Clinical Immunology, Nagoya City 
      University Graduate School of Medical Sciences, Japan.
FAU - Nakano, Akiko
AU  - Nakano A
AD  - Department of Respiratory Medicine and Allergy, Nagoya City University Midori 
      Municipal Hospital, Japan.
FAU - Horiuchi, Minoru
AU  - Horiuchi M
AD  - Department of Respiratory Medicine and Allergy, Nagoya City University Midori 
      Municipal Hospital, Japan.
FAU - Mori, Yuta
AU  - Mori Y
AD  - Department of Respiratory Medicine, Allergy and Clinical Immunology, Nagoya City 
      University Graduate School of Medical Sciences, Japan.
FAU - Fukumitsu, Kensuke
AU  - Fukumitsu K
AD  - Department of Respiratory Medicine, Allergy and Clinical Immunology, Nagoya City 
      University Graduate School of Medical Sciences, Japan.
FAU - Fukuda, Satoshi
AU  - Fukuda S
AD  - Department of Respiratory Medicine, Allergy and Clinical Immunology, Nagoya City 
      University Graduate School of Medical Sciences, Japan.
FAU - Kanemitsu, Yoshihiro
AU  - Kanemitsu Y
AD  - Department of Respiratory Medicine, Allergy and Clinical Immunology, Nagoya City 
      University Graduate School of Medical Sciences, Japan.
FAU - Uemura, Takehiro
AU  - Uemura T
AD  - Department of Respiratory Medicine, Allergy and Clinical Immunology, Nagoya City 
      University Graduate School of Medical Sciences, Japan.
FAU - Tajiri, Tomoko
AU  - Tajiri T
AD  - Department of Respiratory Medicine, Allergy and Clinical Immunology, Nagoya City 
      University Graduate School of Medical Sciences, Japan.
FAU - Ito, Yutaka
AU  - Ito Y
AD  - Department of Respiratory Medicine, Allergy and Clinical Immunology, Nagoya City 
      University Graduate School of Medical Sciences, Japan.
FAU - Ozawa, Yoshiyuki
AU  - Ozawa Y
AD  - Department of Radiology, Fujita Health University Okazaki Medical Center of 
      Radiology, Japan.
FAU - Murase, Takayuki
AU  - Murase T
AD  - Department of Pathology and Molecular Diagnostics, Graduate School of Medical 
      Sciences, Nagoya City University, Japan.
FAU - Niimi, Akio
AU  - Niimi A
AD  - Department of Respiratory Medicine, Allergy and Clinical Immunology, Nagoya City 
      University Graduate School of Medical Sciences, Japan.
LA  - eng
PT  - Journal Article
DEP - 20231013
PL  - Japan
TA  - Intern Med
JT  - Internal medicine (Tokyo, Japan)
JID - 9204241
SB  - IM
MH  - Humans
MH  - *Sarcopenia/diagnostic imaging/physiopathology
MH  - *Idiopathic Pulmonary Fibrosis/complications/physiopathology/diagnostic imaging
MH  - Male
MH  - Aged
MH  - Female
MH  - *Walk Test
MH  - Aged, 80 and over
MH  - *Paraspinal Muscles/diagnostic imaging/physiopathology
MH  - Prospective Studies
MH  - Tomography, X-Ray Computed
MH  - Middle Aged
MH  - Walking/physiology
MH  - Vital Capacity
OTO - NOTNLM
OT  - 6-minute walk test
OT  - computed tomography
OT  - daily step count
OT  - erector spinae muscle
OT  - idiopathic pulmonary fibrosis
OT  - sarcopenia
EDAT- 2023/10/16 00:42
MHDA- 2024/05/16 00:44
CRDT- 2023/10/15 21:23
PHST- 2024/05/16 00:44 [medline]
PHST- 2023/10/16 00:42 [pubmed]
PHST- 2023/10/15 21:23 [entrez]
AID - 10.2169/internalmedicine.2584-23 [doi]
PST - ppublish
SO  - Intern Med. 2024 May 15;63(10):1345-1352. doi: 10.2169/internalmedicine.2584-23. 
      Epub 2023 Oct 13.