PMID- 37840805
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231020
IS  - 1664-0640 (Print)
IS  - 1664-0640 (Electronic)
IS  - 1664-0640 (Linking)
VI  - 14
DP  - 2023
TI  - The effect of stressful life events on the risk for psychosis: differences 
      between Mexican at clinical and familial high risk.
PG  - 1254993
LID - 10.3389/fpsyt.2023.1254993 [doi]
LID - 1254993
AB  - BACKGROUND: Stressful life events (SLEs) in the development of early psychosis 
      have been little studied in low-income countries. This study examines differences 
      in the prevalence of SLEs in Mexican at clinical high risk (CHR) and those with 
      familial high risk for psychosis who do not meet CHR criteria (non-CHR FHR). We 
      also analyze the association between SLEs and CHR. METHODS: Participants included 
      43 persons with CHR and 35 with non-CHR FHR. CHR criteria were assessed with the 
      Comprehensive Assessment of At-Risk Mental State. SLEs were assessed using the 
      Questionnaire of Stressful Life Events. RESULTS: Participants with CHR reported 
      more SLEs associated with negative academic experiences than those in the non-CHR 
      FHR group. Bullying (OR = 7.77, 95% CI [1.81, 33.32]) and low educational level 
      (OR = 21.25, 95% CI [5.19, 46.90]) were the strongest predictors of CHR, while 
      starting to live with a partner (OR = 0.26, 95% CI [0.10, 0.84]) was associated 
      with a lower risk of CHR. CONCLUSION: Negative school experiences increase the 
      risk of psychosis, particularly bullying, suggesting that schools may be ideal 
      settings for implementing individual preventive strategies to reduce risk factors 
      and increase protective factors to improve the prognosis of those at risk of 
      developing psychosis. In Latin America, there are multiple barriers to early 
      intervention in psychosis. It is thus crucial to identify risk and protective 
      factors at the onset and in the course of psychosis in order to design effective 
      preventive interventions.
CI  - Copyright (c) 2023 Nieto, Dominguez-Martinez, Navarrete, Rosel-Vales, 
      Saracco-Alvarez, Celada-Borja, Rascon-Gasca and Moncayo Samperio.
FAU - Nieto, Lourdes
AU  - Nieto L
AD  - Centro de Investigacion en Salud Mental Global, Direccion de Investigaciones 
      Epidemiologicas y Psicosociales, Instituto Nacional de Psiquiatria Ramon de la 
      Fuente Muniz-UNAM, Mexico City, Mexico.
FAU - Dominguez-Martinez, Tecelli
AU  - Dominguez-Martinez T
AD  - Centro de Investigacion en Salud Mental Global, Direccion de Investigaciones 
      Epidemiologicas y Psicosociales, Instituto Nacional de Psiquiatria Ramon de la 
      Fuente Muniz-UNAM, Mexico City, Mexico.
FAU - Navarrete, Laura
AU  - Navarrete L
AD  - Departamento de Estudios Psicosociales en Poblaciones Especificas, Direccion de 
      Investigaciones Epidemiologicas y Psicosociales, Instituto Nacional de 
      Psiquiatria Ramon de la Fuente Muniz, Mexico City, Mexico.
FAU - Rosel-Vales, Mauricio
AU  - Rosel-Vales M
AD  - Clinica de Esquizofrenia, Instituto Nacional de Psiquiatria Ramon de la Fuente 
      Muniz, Mexico City, Mexico.
FAU - Saracco-Alvarez, Ricardo
AU  - Saracco-Alvarez R
AD  - Subdireccion de Investigaciones Clinicas, Instituto Nacional de Psiquiatria Ramon 
      de la Fuente Muniz, Mexico City, Mexico.
FAU - Celada-Borja, Cesar
AU  - Celada-Borja C
AD  - Clinica de Esquizofrenia, Instituto Nacional de Psiquiatria Ramon de la Fuente 
      Muniz, Mexico City, Mexico.
FAU - Rascon-Gasca, Maria Luisa
AU  - Rascon-Gasca ML
AD  - Departamento de Ciencias Sociales en Salud, Direccion de Investigaciones 
      Epidemiologicas y Psicosociales, Instituto Nacional de Psiquiatria Ramon de la 
      Fuente Muniz, Mexico City, Mexico.
FAU - Samperio, Luis Gerardo Moncayo
AU  - Samperio LGM
AD  - Direccion de Servicios Clinicos, Instituto Nacional de Psiquiatria Ramon de la 
      Fuente Muniz, Mexico City, Mexico.
LA  - eng
PT  - Journal Article
DEP - 20230929
PL  - Switzerland
TA  - Front Psychiatry
JT  - Frontiers in psychiatry
JID - 101545006
PMC - PMC10570822
OTO - NOTNLM
OT  - bullying
OT  - clinical high risk
OT  - developing countries
OT  - familial high risk
OT  - psychosis
OT  - stressful life events
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2023/10/16 06:48
MHDA- 2023/10/16 06:49
PMCR- 2023/09/29
CRDT- 2023/10/16 04:22
PHST- 2023/07/08 00:00 [received]
PHST- 2023/09/18 00:00 [accepted]
PHST- 2023/10/16 06:49 [medline]
PHST- 2023/10/16 06:48 [pubmed]
PHST- 2023/10/16 04:22 [entrez]
PHST- 2023/09/29 00:00 [pmc-release]
AID - 10.3389/fpsyt.2023.1254993 [doi]
PST - epublish
SO  - Front Psychiatry. 2023 Sep 29;14:1254993. doi: 10.3389/fpsyt.2023.1254993. 
      eCollection 2023.