PMID- 37840921
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231020
IS  - 1664-2295 (Print)
IS  - 1664-2295 (Electronic)
IS  - 1664-2295 (Linking)
VI  - 14
DP  - 2023
TI  - Stroke-induced damage on the blood-brain barrier.
PG  - 1248970
LID - 10.3389/fneur.2023.1248970 [doi]
LID - 1248970
AB  - The blood-brain barrier (BBB) is a functional phenotype exhibited by the 
      neurovascular unit (NVU). It is maintained and regulated by the interaction 
      between cellular and non-cellular matrix components of the NVU. The BBB plays a 
      vital role in maintaining the dynamic stability of the intracerebral 
      microenvironment as a barrier layer at the critical interface between the blood 
      and neural tissues. The large contact area (approximately 20 m(2)/1.3 kg brain) 
      and short diffusion distance between neurons and capillaries allow endothelial 
      cells to dominate the regulatory role. The NVU is a structural component of the 
      BBB. Individual cells and components of the NVU work together to maintain BBB 
      stability. One of the hallmarks of acute ischemic stroke is the disruption of the 
      BBB, including impaired function of the tight junction and other molecules, as 
      well as increased BBB permeability, leading to brain edema and a range of 
      clinical symptoms. This review summarizes the cellular composition of the BBB and 
      describes the protein composition of the barrier functional junction complex and 
      the mechanisms regulating acute ischemic stroke-induced BBB disruption.
CI  - Copyright (c) 2023 Xue, Zhou, Yang, Si and Sun.
FAU - Xue, Song
AU  - Xue S
AD  - Stroke Center, Department of Neurology, The First Hospital of Jilin University, 
      Changchun, China.
FAU - Zhou, Xin
AU  - Zhou X
AD  - Stroke Center, Department of Neurology, The First Hospital of Jilin University, 
      Changchun, China.
FAU - Yang, Zhi-Hui
AU  - Yang ZH
AD  - Stroke Center, Department of Neurology, The First Hospital of Jilin University, 
      Changchun, China.
FAU - Si, Xiang-Kun
AU  - Si XK
AD  - Stroke Center, Department of Neurology, The First Hospital of Jilin University, 
      Changchun, China.
FAU - Sun, Xin
AU  - Sun X
AD  - Stroke Center, Department of Neurology, The First Hospital of Jilin University, 
      Changchun, China.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20230928
PL  - Switzerland
TA  - Front Neurol
JT  - Frontiers in neurology
JID - 101546899
PMC - PMC10569696
OTO - NOTNLM
OT  - astrocytes
OT  - blood-brain barrier
OT  - ischemic stroke
OT  - microvascular endothelial cells
OT  - neurovascular unit
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2023/10/16 06:48
MHDA- 2023/10/16 06:49
PMCR- 2023/09/28
CRDT- 2023/10/16 04:24
PHST- 2023/06/27 00:00 [received]
PHST- 2023/08/08 00:00 [accepted]
PHST- 2023/10/16 06:49 [medline]
PHST- 2023/10/16 06:48 [pubmed]
PHST- 2023/10/16 04:24 [entrez]
PHST- 2023/09/28 00:00 [pmc-release]
AID - 10.3389/fneur.2023.1248970 [doi]
PST - epublish
SO  - Front Neurol. 2023 Sep 28;14:1248970. doi: 10.3389/fneur.2023.1248970. 
      eCollection 2023.